Utilising cardiopulmonary bypass for cancer surgery. Malignancy-induced protein C deficiency and thrombophilia.

Hdl Handle:
http://hdl.handle.net/10147/208851
Title:
Utilising cardiopulmonary bypass for cancer surgery. Malignancy-induced protein C deficiency and thrombophilia.
Authors:
Marshall, C
Affiliation:
Cardiac Surgery Theatres, Perfusion Office, Cork University Hospital, Wilton,, Cork, Ireland. cornelius_m23@hotmail.com
Citation:
Perfusion. 2007 Nov;22(6):381-3.
Journal:
Perfusion
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/208851
PubMed ID:
18666739
Abstract:
Cardiopulmonary bypass has evolved over the last 30 years. It is an important tool for the cardiac surgeon today and also has applications in non-cardiac operations such as surgery to extract tumours. Such patients undergoing surgery for cancer may be at an increased risk of a thromboembolic event post surgery, due to disturbances in the normal clotting pathway leading to hypercoagulability. One such disturbance is malignancy-induced Protein C deficiency. A deficiency of Protein C can cause hypercoagulabitity. Recent studies have examined cardiopulmonary bypass and inherited Protein C deficiency. However, surgery for cancer patients with a malignancy-induced Protein C deficiency involving cardiopulmonary bypass has not been reported. Surgery using CPB in these patients may result in increased morbidity and mortality. The objective of this article is to review the literature in order to discuss the occurrence, the aetiology and possible management of cancer patients with malignancy-induced Protein C deficiencies that require cardiopulmonary bypass for their surgery.
Language:
eng
MeSH:
*Cardiopulmonary Bypass; Hemostasis; Humans; Neoplasms/complications/*surgery; Postoperative Complications/*etiology; Protein C Deficiency/diagnosis/*etiology; Thrombophilia/*etiology
ISSN:
0267-6591 (Print); 0267-6591 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorMarshall, Cen_GB
dc.date.accessioned2012-02-03T15:05:26Z-
dc.date.available2012-02-03T15:05:26Z-
dc.date.issued2012-02-03T15:05:26Z-
dc.identifier.citationPerfusion. 2007 Nov;22(6):381-3.en_GB
dc.identifier.issn0267-6591 (Print)en_GB
dc.identifier.issn0267-6591 (Linking)en_GB
dc.identifier.pmid18666739en_GB
dc.identifier.urihttp://hdl.handle.net/10147/208851-
dc.description.abstractCardiopulmonary bypass has evolved over the last 30 years. It is an important tool for the cardiac surgeon today and also has applications in non-cardiac operations such as surgery to extract tumours. Such patients undergoing surgery for cancer may be at an increased risk of a thromboembolic event post surgery, due to disturbances in the normal clotting pathway leading to hypercoagulability. One such disturbance is malignancy-induced Protein C deficiency. A deficiency of Protein C can cause hypercoagulabitity. Recent studies have examined cardiopulmonary bypass and inherited Protein C deficiency. However, surgery for cancer patients with a malignancy-induced Protein C deficiency involving cardiopulmonary bypass has not been reported. Surgery using CPB in these patients may result in increased morbidity and mortality. The objective of this article is to review the literature in order to discuss the occurrence, the aetiology and possible management of cancer patients with malignancy-induced Protein C deficiencies that require cardiopulmonary bypass for their surgery.en_GB
dc.language.isoengen_GB
dc.subject.mesh*Cardiopulmonary Bypassen_GB
dc.subject.meshHemostasisen_GB
dc.subject.meshHumansen_GB
dc.subject.meshNeoplasms/complications/*surgeryen_GB
dc.subject.meshPostoperative Complications/*etiologyen_GB
dc.subject.meshProtein C Deficiency/diagnosis/*etiologyen_GB
dc.subject.meshThrombophilia/*etiologyen_GB
dc.titleUtilising cardiopulmonary bypass for cancer surgery. Malignancy-induced protein C deficiency and thrombophilia.en_GB
dc.contributor.departmentCardiac Surgery Theatres, Perfusion Office, Cork University Hospital, Wilton,, Cork, Ireland. cornelius_m23@hotmail.comen_GB
dc.identifier.journalPerfusionen_GB
dc.description.provinceMunster-

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