Functional dyspepsia: the role of visceral hypersensitivity in its pathogenesis.
Affiliation
Department of Medicine, Alimentary Pharmabiotic Centre, Clinical Sciences, Building, Cork University Hospital, Cork, Ireland.Issue Date
2012-02-03T15:05:10ZMeSH
Analgesics/pharmacology/therapeutic useCentral Nervous System/drug effects/physiopathology
Dyspepsia/drug therapy/*etiology/*physiopathology
Efferent Pathways/drug effects/physiopathology
Enteric Nervous System/drug effects/physiopathology
Food Hypersensitivity/complications/physiopathology
Gastrointestinal Tract/*innervation/*physiopathology
Helicobacter Infections/complications/physiopathology
Helicobacter pylori
Humans
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World J Gastroenterol. 2006 May 7;12(17):2672-6.Journal
World journal of gastroenterology : WJGPubMed ID
16718751Abstract
Functional, or non-ulcer, dyspepsia (FD) is one of the most common reasons for referral to gastroenterologists. It is associated with significant morbidity and impaired quality of life. Many authorities believe that functional dyspepsia and irritable bowel syndrome represent part of the spectrum of the same disease process. The pathophysiology of FD remains unclear but several theories have been proposed including visceral hypersensitivity, gastric motor dysfunction, Helicobacter pylori infection and psychosocial factors. In this review, we look at the evidence, to date, for the role of visceral hypersensitivity in the aetiology of FD.Language
engISSN
1007-9327 (Print)1007-9327 (Linking)