Hdl Handle:
http://hdl.handle.net/10147/208842
Title:
Perioperative acute renal failure.
Authors:
Mahon, Padraig; Shorten, George
Affiliation:
Department of Anaesthesia, Cork University Hospital, Wilton, Cork, Ireland., rsimahon@hotmail.com
Citation:
Curr Opin Anaesthesiol. 2006 Jun;19(3):332-8.
Journal:
Current opinion in anaesthesiology
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/208842
DOI:
10.1097/01.aco.0000192819.76353.b3
PubMed ID:
16735819
Abstract:
PURPOSE OF REVIEW: Recent biochemical evidence increasingly implicates inflammatory mechanisms as precipitants of acute renal failure. In this review, we detail some of these pathways together with potential new therapeutic targets. RECENT FINDINGS: Neutrophil gelatinase-associated lipocalin appears to be a sensitive, specific and reliable biomarker of renal injury, which may be predictive of renal outcome in the perioperative setting. For estimation of glomerular filtration rate, cystatin C is superior to creatinine. No drug is definitively effective at preventing postoperative renal failure. Clinical trials of fenoldopam and atrial natriuretic peptide are, at best, equivocal. As with pharmacological preconditioning of the heart, volatile anaesthetic agents appear to offer a protective effect to the subsequently ischaemic kidney. SUMMARY: Although a greatly improved understanding of the pathophysiology of acute renal failure has offered even more therapeutic targets, the maintenance of intravascular euvolaemia and perfusion pressure is most effective at preventing new postoperative acute renal failure. In the future, strategies targeting renal regeneration after injury will use bone marrow-derived stem cells and growth factors such as insulin-like growth factor-1.
Language:
eng
MeSH:
*Acute Kidney Injury/drug therapy/etiology/prevention & control; Animals; Humans; *Postoperative Complications/drug therapy/etiology/prevention & control; Rats; Risk Factors
ISSN:
0952-7907 (Print); 0952-7907 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorMahon, Padraigen_GB
dc.contributor.authorShorten, Georgeen_GB
dc.date.accessioned2012-02-03T15:05:09Z-
dc.date.available2012-02-03T15:05:09Z-
dc.date.issued2012-02-03T15:05:09Z-
dc.identifier.citationCurr Opin Anaesthesiol. 2006 Jun;19(3):332-8.en_GB
dc.identifier.issn0952-7907 (Print)en_GB
dc.identifier.issn0952-7907 (Linking)en_GB
dc.identifier.pmid16735819en_GB
dc.identifier.doi10.1097/01.aco.0000192819.76353.b3en_GB
dc.identifier.urihttp://hdl.handle.net/10147/208842-
dc.description.abstractPURPOSE OF REVIEW: Recent biochemical evidence increasingly implicates inflammatory mechanisms as precipitants of acute renal failure. In this review, we detail some of these pathways together with potential new therapeutic targets. RECENT FINDINGS: Neutrophil gelatinase-associated lipocalin appears to be a sensitive, specific and reliable biomarker of renal injury, which may be predictive of renal outcome in the perioperative setting. For estimation of glomerular filtration rate, cystatin C is superior to creatinine. No drug is definitively effective at preventing postoperative renal failure. Clinical trials of fenoldopam and atrial natriuretic peptide are, at best, equivocal. As with pharmacological preconditioning of the heart, volatile anaesthetic agents appear to offer a protective effect to the subsequently ischaemic kidney. SUMMARY: Although a greatly improved understanding of the pathophysiology of acute renal failure has offered even more therapeutic targets, the maintenance of intravascular euvolaemia and perfusion pressure is most effective at preventing new postoperative acute renal failure. In the future, strategies targeting renal regeneration after injury will use bone marrow-derived stem cells and growth factors such as insulin-like growth factor-1.en_GB
dc.language.isoengen_GB
dc.subject.mesh*Acute Kidney Injury/drug therapy/etiology/prevention & controlen_GB
dc.subject.meshAnimalsen_GB
dc.subject.meshHumansen_GB
dc.subject.mesh*Postoperative Complications/drug therapy/etiology/prevention & controlen_GB
dc.subject.meshRatsen_GB
dc.subject.meshRisk Factorsen_GB
dc.titlePerioperative acute renal failure.en_GB
dc.contributor.departmentDepartment of Anaesthesia, Cork University Hospital, Wilton, Cork, Ireland., rsimahon@hotmail.comen_GB
dc.identifier.journalCurrent opinion in anaesthesiologyen_GB
dc.description.provinceMunster-

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