Cytokine orchestration in post-operative peritoneal adhesion formation.

Hdl Handle:
http://hdl.handle.net/10147/208840
Title:
Cytokine orchestration in post-operative peritoneal adhesion formation.
Authors:
Cahill, Ronan A; Redmond, H Paul
Affiliation:
Department of General Surgery, Cork University Hospital, Wilton, Cork, Ireland., rcahill@rcsi.ie
Citation:
World J Gastroenterol. 2008 Aug 21;14(31):4861-6.
Journal:
World journal of gastroenterology : WJG
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/208840
PubMed ID:
18756592
Abstract:
Peritoneal adhesions are a near inevitable occurrence after laparotomy and a major cause of both patient and physician misery. To date, clinical attempts at their amelioration have concentrated on manipulating the physical factors that affect their development despite a wealth of experimental data elucidating the molecular mechanisms that underlie their initiation, development and maturation. However, the advent of targeted, specific anti-cytokine agents as directed therapy for inflammatory and neoplastic conditions raises the prospect of a new era for anti-adhesion strategies. To harness this potential will require considerable cross-disciplinary collaboration and that surgeon-scientists propel themselves to the forefront of this emerging field.
Language:
eng
MeSH:
Biomedical Research; Cytokines/antagonists & inhibitors/*metabolism; Drugs, Investigational/therapeutic use; Humans; Laparotomy/*adverse effects; Peritoneal Diseases/drug therapy/etiology/*immunology/pathology; Tissue Adhesions; Treatment Outcome
ISSN:
1007-9327 (Print); 1007-9327 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorCahill, Ronan Aen_GB
dc.contributor.authorRedmond, H Paulen_GB
dc.date.accessioned2012-02-03T15:05:05Z-
dc.date.available2012-02-03T15:05:05Z-
dc.date.issued2012-02-03T15:05:05Z-
dc.identifier.citationWorld J Gastroenterol. 2008 Aug 21;14(31):4861-6.en_GB
dc.identifier.issn1007-9327 (Print)en_GB
dc.identifier.issn1007-9327 (Linking)en_GB
dc.identifier.pmid18756592en_GB
dc.identifier.urihttp://hdl.handle.net/10147/208840-
dc.description.abstractPeritoneal adhesions are a near inevitable occurrence after laparotomy and a major cause of both patient and physician misery. To date, clinical attempts at their amelioration have concentrated on manipulating the physical factors that affect their development despite a wealth of experimental data elucidating the molecular mechanisms that underlie their initiation, development and maturation. However, the advent of targeted, specific anti-cytokine agents as directed therapy for inflammatory and neoplastic conditions raises the prospect of a new era for anti-adhesion strategies. To harness this potential will require considerable cross-disciplinary collaboration and that surgeon-scientists propel themselves to the forefront of this emerging field.en_GB
dc.language.isoengen_GB
dc.subject.meshBiomedical Researchen_GB
dc.subject.meshCytokines/antagonists & inhibitors/*metabolismen_GB
dc.subject.meshDrugs, Investigational/therapeutic useen_GB
dc.subject.meshHumansen_GB
dc.subject.meshLaparotomy/*adverse effectsen_GB
dc.subject.meshPeritoneal Diseases/drug therapy/etiology/*immunology/pathologyen_GB
dc.subject.meshTissue Adhesionsen_GB
dc.subject.meshTreatment Outcomeen_GB
dc.titleCytokine orchestration in post-operative peritoneal adhesion formation.en_GB
dc.contributor.departmentDepartment of General Surgery, Cork University Hospital, Wilton, Cork, Ireland., rcahill@rcsi.ieen_GB
dc.identifier.journalWorld journal of gastroenterology : WJGen_GB
dc.description.provinceMunster-

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