The emerging role of toll-like receptor pathways in surgical diseases.

Hdl Handle:
http://hdl.handle.net/10147/208836
Title:
The emerging role of toll-like receptor pathways in surgical diseases.
Authors:
Romics, Laszlo Jr; Szabo, Gyongyi; Coffey, John Calvin; Wang, Jiang Huai; Redmond, Henry Paul
Affiliation:
Department of Surgery, Cork University Hospital, National University of Ireland, , Cork.
Citation:
Arch Surg. 2006 Jun;141(6):595-601.
Journal:
Archives of surgery (Chicago, Ill. : 1960)
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/208836
DOI:
10.1001/archsurg.141.6.595
PubMed ID:
16785361
Abstract:
OBJECTIVE: To outline the emerging significance of Toll-like receptor (TLR) signaling pathways in surgical diseases. DATA SOURCES: A systematic review of the literature was undertaken by searching the MEDLINE database for the period 1966 to 2005 without language restriction. STUDY SELECTION: Original or review articles that described experimental data on the activation of TLR signaling pathways in surgically relevant diseases were selected for inclusion in this review. DATA EXTRACTION: Data were obtained from peer-reviewed articles and references. DATA SYNTHESIS: The role of TLRs in the recognition of pathogens renders them a key figure in the activation of both innate and adaptive immune responses during sepsis. However, emerging evidence points to fundamentally important roles in ulcerative colitis, Crohn disease, and Helicobacter pylori infection in the gastrointestinal tract and in the development of atherosclerotic plaques in the cardiovascular system. Furthermore, recent studies suggest that the regulation of the TLR pathway fulfills a central role in anticancer immunotherapy and in organ rejection after transplantation. CONCLUSION: Given the clinical significance of TLR pathways, the targeting of individual molecular components is likely to offer a broad range of future therapeutic modalities.
Language:
eng
MeSH:
Animals; Cardiovascular Diseases/immunology; Gastrointestinal Diseases/immunology; Gastrointestinal Tract/immunology; Graft Rejection/immunology; Humans; Neoplasms/immunology; Signal Transduction/physiology; Systemic Inflammatory Response Syndrome/*immunology; Toll-Like Receptors/*physiology
ISSN:
0004-0010 (Print); 0004-0010 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorRomics, Laszlo Jren_GB
dc.contributor.authorSzabo, Gyongyien_GB
dc.contributor.authorCoffey, John Calvinen_GB
dc.contributor.authorWang, Jiang Huaien_GB
dc.contributor.authorRedmond, Henry Paulen_GB
dc.date.accessioned2012-02-03T15:04:57Z-
dc.date.available2012-02-03T15:04:57Z-
dc.date.issued2012-02-03T15:04:57Z-
dc.identifier.citationArch Surg. 2006 Jun;141(6):595-601.en_GB
dc.identifier.issn0004-0010 (Print)en_GB
dc.identifier.issn0004-0010 (Linking)en_GB
dc.identifier.pmid16785361en_GB
dc.identifier.doi10.1001/archsurg.141.6.595en_GB
dc.identifier.urihttp://hdl.handle.net/10147/208836-
dc.description.abstractOBJECTIVE: To outline the emerging significance of Toll-like receptor (TLR) signaling pathways in surgical diseases. DATA SOURCES: A systematic review of the literature was undertaken by searching the MEDLINE database for the period 1966 to 2005 without language restriction. STUDY SELECTION: Original or review articles that described experimental data on the activation of TLR signaling pathways in surgically relevant diseases were selected for inclusion in this review. DATA EXTRACTION: Data were obtained from peer-reviewed articles and references. DATA SYNTHESIS: The role of TLRs in the recognition of pathogens renders them a key figure in the activation of both innate and adaptive immune responses during sepsis. However, emerging evidence points to fundamentally important roles in ulcerative colitis, Crohn disease, and Helicobacter pylori infection in the gastrointestinal tract and in the development of atherosclerotic plaques in the cardiovascular system. Furthermore, recent studies suggest that the regulation of the TLR pathway fulfills a central role in anticancer immunotherapy and in organ rejection after transplantation. CONCLUSION: Given the clinical significance of TLR pathways, the targeting of individual molecular components is likely to offer a broad range of future therapeutic modalities.en_GB
dc.language.isoengen_GB
dc.subject.meshAnimalsen_GB
dc.subject.meshCardiovascular Diseases/immunologyen_GB
dc.subject.meshGastrointestinal Diseases/immunologyen_GB
dc.subject.meshGastrointestinal Tract/immunologyen_GB
dc.subject.meshGraft Rejection/immunologyen_GB
dc.subject.meshHumansen_GB
dc.subject.meshNeoplasms/immunologyen_GB
dc.subject.meshSignal Transduction/physiologyen_GB
dc.subject.meshSystemic Inflammatory Response Syndrome/*immunologyen_GB
dc.subject.meshToll-Like Receptors/*physiologyen_GB
dc.titleThe emerging role of toll-like receptor pathways in surgical diseases.en_GB
dc.contributor.departmentDepartment of Surgery, Cork University Hospital, National University of Ireland, , Cork.en_GB
dc.identifier.journalArchives of surgery (Chicago, Ill. : 1960)en_GB
dc.description.provinceMunster-

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