Plasma cytokine profiles in depressed patients who fail to respond to selective serotonin reuptake inhibitor therapy.

Hdl Handle:
http://hdl.handle.net/10147/208831
Title:
Plasma cytokine profiles in depressed patients who fail to respond to selective serotonin reuptake inhibitor therapy.
Authors:
O'Brien, Sinead M; Scully, Paul; Fitzgerald, Peter; Scott, Lucinda V; Dinan, Timothy G
Affiliation:
Alimentary Pharmabiotic Centre and Department of Psychiatry, Cork University, Hospital, Wilton, Cork, Ireland.
Citation:
J Psychiatr Res. 2007 Apr-Jun;41(3-4):326-31. Epub 2006 Jul 25.
Journal:
Journal of psychiatric research
Issue Date:
3-Feb-2012
URI:
http://hdl.handle.net/10147/208831
DOI:
10.1016/j.jpsychires.2006.05.013
PubMed ID:
16870211
Abstract:
OBJECTIVE: Approximately 30% of patients with depression fail to respond to a selective serotonin reuptake inhibitor (SSRI). Few studies have attempted to define these patients from a biological perspective. Studies suggest that overall patients with depression show increased production of proinflammatory cytokines. We examined pro- and anti-inflammatory cytokine levels in patients who were SSRI resistant. METHODS: Plasma concentrations of IL-6, IL-8, IL-10, TNF-alpha and sIL-6R were measured with enzyme linked immunosorbent assays (ELISA) in DSM-1V major depressives who were SSRI resistant, in formerly SSRI resistant patients currently euthymic and in healthy controls. RESULTS: Patients with SSRI-resistant depression had significantly higher production of the pro-inflammatory cytokines IL-6 (p=0.01) and TNF-alpha (p=0.004) compared to normal controls. Euthymic patients who were formerly SSRI resistant had proinflammatory cytokine levels which were similar to the healthy subject group. Anti-inflammatory cytokine levels did not differ across the 3 groups. CONCLUSION: Suppression of proinflammatory cytokines does not occur in depressed patients who fail to respond to SSRIs and is necessary for clinical recovery.
Language:
eng
MeSH:
Adult; Analysis of Variance; Antidepressive Agents/*therapeutic use; Cytokines/*blood; Depressive Disorder, Major/*blood/drug therapy; Drug Resistance/*physiology; Enzyme-Linked Immunosorbent Assay/methods; Female; Humans; Male; Middle Aged; Psychiatric Status Rating Scales; Serotonin Uptake Inhibitors/*therapeutic use
ISSN:
0022-3956 (Print); 0022-3956 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorO'Brien, Sinead Men_GB
dc.contributor.authorScully, Paulen_GB
dc.contributor.authorFitzgerald, Peteren_GB
dc.contributor.authorScott, Lucinda Ven_GB
dc.contributor.authorDinan, Timothy Gen_GB
dc.date.accessioned2012-02-03T15:04:47Z-
dc.date.available2012-02-03T15:04:47Z-
dc.date.issued2012-02-03T15:04:47Z-
dc.identifier.citationJ Psychiatr Res. 2007 Apr-Jun;41(3-4):326-31. Epub 2006 Jul 25.en_GB
dc.identifier.issn0022-3956 (Print)en_GB
dc.identifier.issn0022-3956 (Linking)en_GB
dc.identifier.pmid16870211en_GB
dc.identifier.doi10.1016/j.jpsychires.2006.05.013en_GB
dc.identifier.urihttp://hdl.handle.net/10147/208831-
dc.description.abstractOBJECTIVE: Approximately 30% of patients with depression fail to respond to a selective serotonin reuptake inhibitor (SSRI). Few studies have attempted to define these patients from a biological perspective. Studies suggest that overall patients with depression show increased production of proinflammatory cytokines. We examined pro- and anti-inflammatory cytokine levels in patients who were SSRI resistant. METHODS: Plasma concentrations of IL-6, IL-8, IL-10, TNF-alpha and sIL-6R were measured with enzyme linked immunosorbent assays (ELISA) in DSM-1V major depressives who were SSRI resistant, in formerly SSRI resistant patients currently euthymic and in healthy controls. RESULTS: Patients with SSRI-resistant depression had significantly higher production of the pro-inflammatory cytokines IL-6 (p=0.01) and TNF-alpha (p=0.004) compared to normal controls. Euthymic patients who were formerly SSRI resistant had proinflammatory cytokine levels which were similar to the healthy subject group. Anti-inflammatory cytokine levels did not differ across the 3 groups. CONCLUSION: Suppression of proinflammatory cytokines does not occur in depressed patients who fail to respond to SSRIs and is necessary for clinical recovery.en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAnalysis of Varianceen_GB
dc.subject.meshAntidepressive Agents/*therapeutic useen_GB
dc.subject.meshCytokines/*blooden_GB
dc.subject.meshDepressive Disorder, Major/*blood/drug therapyen_GB
dc.subject.meshDrug Resistance/*physiologyen_GB
dc.subject.meshEnzyme-Linked Immunosorbent Assay/methodsen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshPsychiatric Status Rating Scalesen_GB
dc.subject.meshSerotonin Uptake Inhibitors/*therapeutic useen_GB
dc.titlePlasma cytokine profiles in depressed patients who fail to respond to selective serotonin reuptake inhibitor therapy.en_GB
dc.contributor.departmentAlimentary Pharmabiotic Centre and Department of Psychiatry, Cork University, Hospital, Wilton, Cork, Ireland.en_GB
dc.identifier.journalJournal of psychiatric researchen_GB
dc.description.provinceMunster-

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