Sentinel lymph node biopsy in node-negative squamous cell carcinoma of the oral cavity and oropharynx.

Hdl Handle:
http://hdl.handle.net/10147/208069
Title:
Sentinel lymph node biopsy in node-negative squamous cell carcinoma of the oral cavity and oropharynx.
Authors:
Burns, P; Foster, A; Walshe, P; O'Dwyer, T
Affiliation:
Department of Otorhinolaryngology, Mater Hospital, Dublin, Ireland., drfatihtunca@yahoo.com
Citation:
J Laryngol Otol. 2009 Apr;123(4):439-43. Epub 2008 Sep 17.
Journal:
The Journal of laryngology and otology
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/208069
DOI:
10.1017/S0022215108003514
PubMed ID:
18796178
Abstract:
OBJECTIVES: Considerable controversy exists regarding the merits of elective neck dissection in patients with early stage oral cavity and oropharyngeal squamous cell carcinoma. It is highly desirable to have a method of identifying those patients who would benefit from further treatment of the neck when they are clinically node-negative. The purpose of the present study was to examine the use of sentinel lymph node biopsy in identifying occult neck disease in a cohort of patients with node-negative oral cavity and oropharyngeal squamous cell carcinoma. DESIGN: We evaluated a total of 13 patients with oral cavity and oropharyngeal cancer who were clinically and radiologically node-negative. RESULTS: A sentinel lymph node was found in all 13 patients, revealing metastatic disease in five patients, four of whom had one or more positive sentinel lymph nodes. There was one false negative result, in which the sentinel lymph node was negative for tumour whereas histological examination of the neck dissection specimen showed occult disease. CONCLUSION: In view of these findings, we would recommend the use of sentinel lymph node biopsy in cases of oral cavity and oropharyngeal squamous cell carcinoma, in order to aid the differentiation of those patients whose necks are harbouring occult disease and who require further treatment.
Language:
eng
MeSH:
Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell/pathology/*secondary/surgery; Female; Humans; Lymph Nodes/*pathology/radionuclide imaging; Lymphatic Metastasis/diagnosis/*pathology; Male; Middle Aged; Mouth Neoplasms/*pathology/surgery; Neck Dissection/methods; Neoplasm Staging; Oropharyngeal Neoplasms/*pathology/surgery; Prospective Studies; Radiopharmaceuticals/diagnostic use; Sentinel Lymph Node Biopsy/*methods; Technetium Tc 99m Aggregated Albumin/diagnostic use
ISSN:
1748-5460 (Electronic); 0022-2151 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorBurns, Pen_GB
dc.contributor.authorFoster, Aen_GB
dc.contributor.authorWalshe, Pen_GB
dc.contributor.authorO'Dwyer, Ten_GB
dc.date.accessioned2012-02-01T11:09:03Z-
dc.date.available2012-02-01T11:09:03Z-
dc.date.issued2012-02-01T11:09:03Z-
dc.identifier.citationJ Laryngol Otol. 2009 Apr;123(4):439-43. Epub 2008 Sep 17.en_GB
dc.identifier.issn1748-5460 (Electronic)en_GB
dc.identifier.issn0022-2151 (Linking)en_GB
dc.identifier.pmid18796178en_GB
dc.identifier.doi10.1017/S0022215108003514en_GB
dc.identifier.urihttp://hdl.handle.net/10147/208069-
dc.description.abstractOBJECTIVES: Considerable controversy exists regarding the merits of elective neck dissection in patients with early stage oral cavity and oropharyngeal squamous cell carcinoma. It is highly desirable to have a method of identifying those patients who would benefit from further treatment of the neck when they are clinically node-negative. The purpose of the present study was to examine the use of sentinel lymph node biopsy in identifying occult neck disease in a cohort of patients with node-negative oral cavity and oropharyngeal squamous cell carcinoma. DESIGN: We evaluated a total of 13 patients with oral cavity and oropharyngeal cancer who were clinically and radiologically node-negative. RESULTS: A sentinel lymph node was found in all 13 patients, revealing metastatic disease in five patients, four of whom had one or more positive sentinel lymph nodes. There was one false negative result, in which the sentinel lymph node was negative for tumour whereas histological examination of the neck dissection specimen showed occult disease. CONCLUSION: In view of these findings, we would recommend the use of sentinel lymph node biopsy in cases of oral cavity and oropharyngeal squamous cell carcinoma, in order to aid the differentiation of those patients whose necks are harbouring occult disease and who require further treatment.en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAgeden_GB
dc.subject.meshAged, 80 and overen_GB
dc.subject.meshCarcinoma, Squamous Cell/pathology/*secondary/surgeryen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshLymph Nodes/*pathology/radionuclide imagingen_GB
dc.subject.meshLymphatic Metastasis/diagnosis/*pathologyen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshMouth Neoplasms/*pathology/surgeryen_GB
dc.subject.meshNeck Dissection/methodsen_GB
dc.subject.meshNeoplasm Stagingen_GB
dc.subject.meshOropharyngeal Neoplasms/*pathology/surgeryen_GB
dc.subject.meshProspective Studiesen_GB
dc.subject.meshRadiopharmaceuticals/diagnostic useen_GB
dc.subject.meshSentinel Lymph Node Biopsy/*methodsen_GB
dc.subject.meshTechnetium Tc 99m Aggregated Albumin/diagnostic useen_GB
dc.titleSentinel lymph node biopsy in node-negative squamous cell carcinoma of the oral cavity and oropharynx.en_GB
dc.contributor.departmentDepartment of Otorhinolaryngology, Mater Hospital, Dublin, Ireland., drfatihtunca@yahoo.comen_GB
dc.identifier.journalThe Journal of laryngology and otologyen_GB
dc.description.provinceLeinster-

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