Medication use in early pregnancy-prevalence and determinants of use in a prospective cohort of women.

Hdl Handle:
http://hdl.handle.net/10147/208043
Title:
Medication use in early pregnancy-prevalence and determinants of use in a prospective cohort of women.
Authors:
Cleary, Brian J; Butt, Hajeera; Strawbridge, Judith D; Gallagher, Paul J; Fahey, Tom; Murphy, Deirdre J
Affiliation:
Coombe Women and Infants University Hospital, Dublin, Republic of Ireland., bcleary@coombe.ie
Citation:
Pharmacoepidemiol Drug Saf. 2010 Apr;19(4):408-17.
Journal:
Pharmacoepidemiology and drug safety
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/208043
DOI:
10.1002/pds.1906
PubMed ID:
20099251
Abstract:
PURPOSE: To examine the extent, nature and determinants of medication use in early pregnancy. METHODS: We reviewed early pregnancy medication use, as reported to a midwife at the booking interview, in women delivering between 2000 and 2007 in a large maternity hospital in Dublin, Ireland (n = 61 252). RESULTS: Excluding folic acid, at least one medication was reported in 23 989 (39.2%) pregnancies. Over the counter (OTC) medications were reported in 11 970 (19.5%) pregnancies, illicit drugs or methadone in 545 (0.9%) and herbal medicines/supplements in 352 (0.58%). FDA category D and X medications were reported by 1532 (2.5%) and 1987 (3.2%) women. Asthma, depression and hypertension were among the most commonly reported chronic medical disorders. Medications with potential for foetal harm were reported by 86 (15.7%) women treated for depression and 68 (20%) women treated for hypertension. Factors associated with reporting the use of medications with potential for foetal harm included unplanned pregnancy (adjusted odds ratio [aOR] 1.31, 95% confidence interval [CI] 1.12-1.52), booking at less than 12 weeks gestation (aOR 1.83, 95%CI 1.58-2.13), being above 25 years of age, unemployed (aOR 2.58, 95%CI 2.03-3.29), nulliparous (aOR 1.41; 95%CI 1.22-1.63), single (aOR 1.28; 95%CI 1.06-1.54) or smoking during pregnancy (aOR 1.96, 95%CI 1.67-2.28). CONCLUSIONS: Women frequently report medication use in early pregnancy. Women and prescribers need to be aware of the lack of pregnancy safety data for many medications, and the need for pre-pregnancy planning. Prescribers should ensure that optimal medications are used when treating women of childbearing potential with chronic medical disorders.
Language:
eng
MeSH:
Adult; Cohort Studies; Drug Utilization Review/*statistics & numerical data; Female; Fetal Development/drug effects; Gestational Age; Humans; *Pharmaceutical Preparations/administration & dosage/adverse; effects/classification; Plant Preparations/administration & dosage/adverse effects/therapeutic use; Pregnancy; Pregnancy Complications/*drug therapy/epidemiology/etiology; Prescription Drugs/administration & dosage/adverse effects/therapeutic use; Prevalence; Prospective Studies; Questionnaires; Street Drugs/adverse effects; United States; United States Food and Drug Administration; Young Adult
ISSN:
1099-1557 (Electronic); 1053-8569 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorCleary, Brian Jen_GB
dc.contributor.authorButt, Hajeeraen_GB
dc.contributor.authorStrawbridge, Judith Den_GB
dc.contributor.authorGallagher, Paul Jen_GB
dc.contributor.authorFahey, Tomen_GB
dc.contributor.authorMurphy, Deirdre Jen_GB
dc.date.accessioned2012-02-01T10:58:34Z-
dc.date.available2012-02-01T10:58:34Z-
dc.date.issued2012-02-01T10:58:34Z-
dc.identifier.citationPharmacoepidemiol Drug Saf. 2010 Apr;19(4):408-17.en_GB
dc.identifier.issn1099-1557 (Electronic)en_GB
dc.identifier.issn1053-8569 (Linking)en_GB
dc.identifier.pmid20099251en_GB
dc.identifier.doi10.1002/pds.1906en_GB
dc.identifier.urihttp://hdl.handle.net/10147/208043-
dc.description.abstractPURPOSE: To examine the extent, nature and determinants of medication use in early pregnancy. METHODS: We reviewed early pregnancy medication use, as reported to a midwife at the booking interview, in women delivering between 2000 and 2007 in a large maternity hospital in Dublin, Ireland (n = 61 252). RESULTS: Excluding folic acid, at least one medication was reported in 23 989 (39.2%) pregnancies. Over the counter (OTC) medications were reported in 11 970 (19.5%) pregnancies, illicit drugs or methadone in 545 (0.9%) and herbal medicines/supplements in 352 (0.58%). FDA category D and X medications were reported by 1532 (2.5%) and 1987 (3.2%) women. Asthma, depression and hypertension were among the most commonly reported chronic medical disorders. Medications with potential for foetal harm were reported by 86 (15.7%) women treated for depression and 68 (20%) women treated for hypertension. Factors associated with reporting the use of medications with potential for foetal harm included unplanned pregnancy (adjusted odds ratio [aOR] 1.31, 95% confidence interval [CI] 1.12-1.52), booking at less than 12 weeks gestation (aOR 1.83, 95%CI 1.58-2.13), being above 25 years of age, unemployed (aOR 2.58, 95%CI 2.03-3.29), nulliparous (aOR 1.41; 95%CI 1.22-1.63), single (aOR 1.28; 95%CI 1.06-1.54) or smoking during pregnancy (aOR 1.96, 95%CI 1.67-2.28). CONCLUSIONS: Women frequently report medication use in early pregnancy. Women and prescribers need to be aware of the lack of pregnancy safety data for many medications, and the need for pre-pregnancy planning. Prescribers should ensure that optimal medications are used when treating women of childbearing potential with chronic medical disorders.en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshCohort Studiesen_GB
dc.subject.meshDrug Utilization Review/*statistics & numerical dataen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshFetal Development/drug effectsen_GB
dc.subject.meshGestational Ageen_GB
dc.subject.meshHumansen_GB
dc.subject.mesh*Pharmaceutical Preparations/administration & dosage/adverseen_GB
dc.subject.mesheffects/classificationen_GB
dc.subject.meshPlant Preparations/administration & dosage/adverse effects/therapeutic useen_GB
dc.subject.meshPregnancyen_GB
dc.subject.meshPregnancy Complications/*drug therapy/epidemiology/etiologyen_GB
dc.subject.meshPrescription Drugs/administration & dosage/adverse effects/therapeutic useen_GB
dc.subject.meshPrevalenceen_GB
dc.subject.meshProspective Studiesen_GB
dc.subject.meshQuestionnairesen_GB
dc.subject.meshStreet Drugs/adverse effectsen_GB
dc.subject.meshUnited Statesen_GB
dc.subject.meshUnited States Food and Drug Administrationen_GB
dc.subject.meshYoung Adulten_GB
dc.titleMedication use in early pregnancy-prevalence and determinants of use in a prospective cohort of women.en_GB
dc.contributor.departmentCoombe Women and Infants University Hospital, Dublin, Republic of Ireland., bcleary@coombe.ieen_GB
dc.identifier.journalPharmacoepidemiology and drug safetyen_GB
dc.description.provinceLeinster-

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