Maternal leptin and body composition in the first trimester of pregnancy.

Hdl Handle:
http://hdl.handle.net/10147/208031
Title:
Maternal leptin and body composition in the first trimester of pregnancy.
Authors:
Fattah, Chro; Barry, Sinead; O'connor, Norah; Farah, Nadine; Stuart, Bernard; Turner, Michael J
Affiliation:
UCD Centre for Human Reproduction, Coombe Women and Infants University Hospital, , Dublin, Ireland.
Citation:
Gynecol Endocrinol. 2011 Apr;27(4):263-6. Epub 2010 Jun 9.
Journal:
Gynecological endocrinology : the official journal of the International Society, of Gynecological Endocrinology
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/208031
DOI:
10.3109/09513590.2010.491167
PubMed ID:
20528571
Abstract:
BACKGROUND: Leptin is produced mainly by adipocytes. Levels are increased in women with obesity and during pregnancy. Increased levels are also associated with pregnancy complications such as, pre-eclampsia and gestational diabetes mellitus. OBJECTIVE: We studied what component of body composition correlated best with maternal leptin in the first trimester of pregnancy and, whether maternal leptin correlated better with visceral fat rather than fat distributed elsewhere. SUBJECTS AND METHODS: Women were recruited in the first trimester. Maternal adiposity was measured using body mass index and advanced bioelectrical impedance analysis. Maternal leptin was measured using an enzyme-linked immunosorbent assay technique. RESULTS: Of the 100 subjects studied, the mean leptin concentration was 37.7 ng/ml (range: 2.1-132.8). Leptin levels did not correlate with gestational age in the first trimester, maternal age, parity or birth weight. Serum leptin correlated positively with maternal weight and body mass index, and with the different parameters of body composition. On multiple regression analysis, serum leptin correlated with visceral fat but not fat distributed elsewhere. CONCLUSIONS: Visceral fat is the main determinant of circulating maternal leptin in the first trimester of pregnancy. This raises the possibility that maternal leptin in early pregnancy may be a marker for the development of metabolic syndrome, including diabetes mellitus.
Language:
eng
MeSH:
Adult; *Body Composition; Female; Humans; Infant, Newborn; *Intra-Abdominal Fat; Leptin/*blood; Pregnancy/*blood; Pregnancy Trimester, First/*blood
ISSN:
1473-0766 (Electronic); 0951-3590 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorFattah, Chroen_GB
dc.contributor.authorBarry, Sineaden_GB
dc.contributor.authorO'connor, Norahen_GB
dc.contributor.authorFarah, Nadineen_GB
dc.contributor.authorStuart, Bernarden_GB
dc.contributor.authorTurner, Michael Jen_GB
dc.date.accessioned2012-02-01T10:58:13Z-
dc.date.available2012-02-01T10:58:13Z-
dc.date.issued2012-02-01T10:58:13Z-
dc.identifier.citationGynecol Endocrinol. 2011 Apr;27(4):263-6. Epub 2010 Jun 9.en_GB
dc.identifier.issn1473-0766 (Electronic)en_GB
dc.identifier.issn0951-3590 (Linking)en_GB
dc.identifier.pmid20528571en_GB
dc.identifier.doi10.3109/09513590.2010.491167en_GB
dc.identifier.urihttp://hdl.handle.net/10147/208031-
dc.description.abstractBACKGROUND: Leptin is produced mainly by adipocytes. Levels are increased in women with obesity and during pregnancy. Increased levels are also associated with pregnancy complications such as, pre-eclampsia and gestational diabetes mellitus. OBJECTIVE: We studied what component of body composition correlated best with maternal leptin in the first trimester of pregnancy and, whether maternal leptin correlated better with visceral fat rather than fat distributed elsewhere. SUBJECTS AND METHODS: Women were recruited in the first trimester. Maternal adiposity was measured using body mass index and advanced bioelectrical impedance analysis. Maternal leptin was measured using an enzyme-linked immunosorbent assay technique. RESULTS: Of the 100 subjects studied, the mean leptin concentration was 37.7 ng/ml (range: 2.1-132.8). Leptin levels did not correlate with gestational age in the first trimester, maternal age, parity or birth weight. Serum leptin correlated positively with maternal weight and body mass index, and with the different parameters of body composition. On multiple regression analysis, serum leptin correlated with visceral fat but not fat distributed elsewhere. CONCLUSIONS: Visceral fat is the main determinant of circulating maternal leptin in the first trimester of pregnancy. This raises the possibility that maternal leptin in early pregnancy may be a marker for the development of metabolic syndrome, including diabetes mellitus.en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.mesh*Body Compositionen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshInfant, Newbornen_GB
dc.subject.mesh*Intra-Abdominal Faten_GB
dc.subject.meshLeptin/*blooden_GB
dc.subject.meshPregnancy/*blooden_GB
dc.subject.meshPregnancy Trimester, First/*blooden_GB
dc.titleMaternal leptin and body composition in the first trimester of pregnancy.en_GB
dc.contributor.departmentUCD Centre for Human Reproduction, Coombe Women and Infants University Hospital, , Dublin, Ireland.en_GB
dc.identifier.journalGynecological endocrinology : the official journal of the International Society, of Gynecological Endocrinologyen_GB
dc.description.provinceLeinster-

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