Hdl Handle:
http://hdl.handle.net/10147/208027
Title:
The treatment of CIN: what are the risks?
Authors:
Prendiville, W
Affiliation:
Royal College of Surgeons in Ireland, Department of Gynaecology, Coombe and, Tallagh Hospital, Dublin, Ireland. walter.prendiville@gmail.com
Citation:
Cytopathology. 2009 Jun;20(3):145-53.
Journal:
Cytopathology : official journal of the British Society for Clinical Cytology
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/208027
DOI:
10.1111/j.1365-2303.2009.00669.x
PubMed ID:
19489986
Abstract:
The treatment of CIN: what are the risks?The treatment of squamous cervical intraepithelial neoplasia is to remove or destroy the transformation zone (TZ). It is likely that no method of treatment is superior to another if it is performed properly and the limited available evidence supports this view. The significant advantages of excision (simplicity, cost, outpatient procedure, histological examination of the entire TZ) mean that treatment thresholds may have lowered over the last decade. Long-term pregnancy-related morbidity associated with excision has been reported recently. The evidence would suggest that this increase equates to a genuine increase in serious adverse outcome for cone biopsy but not large loop excision of the transformation zone (LLETZ). The available data also point to an increase in both incomplete excision and premature labour associated with the excision of large endocervical TZs. The clinical implications arising from this are firstly that women with large type 2 and 3 TZs need appropriate counselling before treatment and that the threshold for treating young women with mild abnormalities needs review.
Language:
eng
MeSH:
Biopsy/methods; Cervical Intraepithelial Neoplasia/pathology/*surgery; Colposcopy/*adverse effects; Female; Guidelines as Topic; Humans; Obstetric Labor, Premature/etiology; Pregnancy; Risk Factors; Uterine Cervical Neoplasms/pathology/*surgery
ISSN:
1365-2303 (Electronic); 0956-5507 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorPrendiville, Wen_GB
dc.date.accessioned2012-02-01T10:58:06Z-
dc.date.available2012-02-01T10:58:06Z-
dc.date.issued2012-02-01T10:58:06Z-
dc.identifier.citationCytopathology. 2009 Jun;20(3):145-53.en_GB
dc.identifier.issn1365-2303 (Electronic)en_GB
dc.identifier.issn0956-5507 (Linking)en_GB
dc.identifier.pmid19489986en_GB
dc.identifier.doi10.1111/j.1365-2303.2009.00669.xen_GB
dc.identifier.urihttp://hdl.handle.net/10147/208027-
dc.description.abstractThe treatment of CIN: what are the risks?The treatment of squamous cervical intraepithelial neoplasia is to remove or destroy the transformation zone (TZ). It is likely that no method of treatment is superior to another if it is performed properly and the limited available evidence supports this view. The significant advantages of excision (simplicity, cost, outpatient procedure, histological examination of the entire TZ) mean that treatment thresholds may have lowered over the last decade. Long-term pregnancy-related morbidity associated with excision has been reported recently. The evidence would suggest that this increase equates to a genuine increase in serious adverse outcome for cone biopsy but not large loop excision of the transformation zone (LLETZ). The available data also point to an increase in both incomplete excision and premature labour associated with the excision of large endocervical TZs. The clinical implications arising from this are firstly that women with large type 2 and 3 TZs need appropriate counselling before treatment and that the threshold for treating young women with mild abnormalities needs review.en_GB
dc.language.isoengen_GB
dc.subject.meshBiopsy/methodsen_GB
dc.subject.meshCervical Intraepithelial Neoplasia/pathology/*surgeryen_GB
dc.subject.meshColposcopy/*adverse effectsen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshGuidelines as Topicen_GB
dc.subject.meshHumansen_GB
dc.subject.meshObstetric Labor, Premature/etiologyen_GB
dc.subject.meshPregnancyen_GB
dc.subject.meshRisk Factorsen_GB
dc.subject.meshUterine Cervical Neoplasms/pathology/*surgeryen_GB
dc.titleThe treatment of CIN: what are the risks?en_GB
dc.contributor.departmentRoyal College of Surgeons in Ireland, Department of Gynaecology, Coombe and, Tallagh Hospital, Dublin, Ireland. walter.prendiville@gmail.comen_GB
dc.identifier.journalCytopathology : official journal of the British Society for Clinical Cytologyen_GB
dc.description.provinceLeinster-
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