Prevalence and predictors of periconceptional folic acid uptake--prospective cohort study in an Irish urban obstetric population.

Hdl Handle:
http://hdl.handle.net/10147/208019
Title:
Prevalence and predictors of periconceptional folic acid uptake--prospective cohort study in an Irish urban obstetric population.
Authors:
McGuire, M; Cleary, B; Sahm, L; Murphy, D J
Affiliation:
Coombe Women and Infants University Hospital, Dolphins Barn, Dublin 8, Ireland.
Citation:
Hum Reprod. 2010 Feb;25(2):535-43. Epub 2009 Nov 12.
Journal:
Human reproduction (Oxford, England)
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/208019
DOI:
10.1093/humrep/dep398
PubMed ID:
19910320
Abstract:
BACKGROUND: Neural tube defects (NTDs) are severe abnormalities of the central nervous system that occur as a result of abnormal development in the third and fourth weeks of gestation. Studies have shown that periconceptional folic acid (FA) can reduce both the incidence and recurrence of NTDs. METHODS: A cohort study was carried out using the electronic hospital booking records of women delivering in a large Dublin maternity hospital between 2000 and 2007. Logistic regression analyses were performed to measure the associations between maternal factors and optimal FA use. RESULTS: Of the 61,252 women in the cohort, 85% reported taking FA at some point during the periconceptional period; however, only 28% took FA as recommended. Factors associated with taking the recommended amount of FA included nulliparity [adjusted OR: 1.35 (95% CI: 1.28-1.43)], early booking (<12 weeks) [OR: 1.24 (95% CI: 1.17-1.31)], increasing maternal age (e.g. 30-34 years) [OR: 1.39 (95% CI: 1.30-1.48)], private health care [OR: 4.32 (95% CI: 4.1-4.6)] and fertility treatment [OR: 2.88 (95% CI: 2.44-3.40)]. Factors associated with taking less than recommended or no FA included unplanned pregnancy [OR: 0.08 (0.07-0.08)], lower socio-economic status (e.g. unemployed) [OR: 0.63 (95% CI: 0.55-0.71)], non-Irish nationality [OR: 0.82 (0.74-0.90)] and smokers [OR: 0.51 (95% CI: 0.47-0.55)]. CONCLUSIONS: Social, demographic and economic factors have an important influence on the FA uptake. Vulnerable groups who report limited uptake of FA need to be specifically targeted in future Public Health campaigns and further consideration needs to be given to the debate on food fortification in countries where this is currently not available.
Language:
eng
MeSH:
Adult; Cohort Studies; Female; Folic Acid/administration & dosage/*metabolism; Humans; Ireland/epidemiology; Neural Tube Defects/*epidemiology; Pregnancy; Prevalence; Socioeconomic Factors; Urban Health; *Urban Population
ISSN:
1460-2350 (Electronic); 0268-1161 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorMcGuire, Men_GB
dc.contributor.authorCleary, Ben_GB
dc.contributor.authorSahm, Len_GB
dc.contributor.authorMurphy, D Jen_GB
dc.date.accessioned2012-02-01T10:57:52Z-
dc.date.available2012-02-01T10:57:52Z-
dc.date.issued2012-02-01T10:57:52Z-
dc.identifier.citationHum Reprod. 2010 Feb;25(2):535-43. Epub 2009 Nov 12.en_GB
dc.identifier.issn1460-2350 (Electronic)en_GB
dc.identifier.issn0268-1161 (Linking)en_GB
dc.identifier.pmid19910320en_GB
dc.identifier.doi10.1093/humrep/dep398en_GB
dc.identifier.urihttp://hdl.handle.net/10147/208019-
dc.description.abstractBACKGROUND: Neural tube defects (NTDs) are severe abnormalities of the central nervous system that occur as a result of abnormal development in the third and fourth weeks of gestation. Studies have shown that periconceptional folic acid (FA) can reduce both the incidence and recurrence of NTDs. METHODS: A cohort study was carried out using the electronic hospital booking records of women delivering in a large Dublin maternity hospital between 2000 and 2007. Logistic regression analyses were performed to measure the associations between maternal factors and optimal FA use. RESULTS: Of the 61,252 women in the cohort, 85% reported taking FA at some point during the periconceptional period; however, only 28% took FA as recommended. Factors associated with taking the recommended amount of FA included nulliparity [adjusted OR: 1.35 (95% CI: 1.28-1.43)], early booking (<12 weeks) [OR: 1.24 (95% CI: 1.17-1.31)], increasing maternal age (e.g. 30-34 years) [OR: 1.39 (95% CI: 1.30-1.48)], private health care [OR: 4.32 (95% CI: 4.1-4.6)] and fertility treatment [OR: 2.88 (95% CI: 2.44-3.40)]. Factors associated with taking less than recommended or no FA included unplanned pregnancy [OR: 0.08 (0.07-0.08)], lower socio-economic status (e.g. unemployed) [OR: 0.63 (95% CI: 0.55-0.71)], non-Irish nationality [OR: 0.82 (0.74-0.90)] and smokers [OR: 0.51 (95% CI: 0.47-0.55)]. CONCLUSIONS: Social, demographic and economic factors have an important influence on the FA uptake. Vulnerable groups who report limited uptake of FA need to be specifically targeted in future Public Health campaigns and further consideration needs to be given to the debate on food fortification in countries where this is currently not available.en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshCohort Studiesen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshFolic Acid/administration & dosage/*metabolismen_GB
dc.subject.meshHumansen_GB
dc.subject.meshIreland/epidemiologyen_GB
dc.subject.meshNeural Tube Defects/*epidemiologyen_GB
dc.subject.meshPregnancyen_GB
dc.subject.meshPrevalenceen_GB
dc.subject.meshSocioeconomic Factorsen_GB
dc.subject.meshUrban Healthen_GB
dc.subject.mesh*Urban Populationen_GB
dc.titlePrevalence and predictors of periconceptional folic acid uptake--prospective cohort study in an Irish urban obstetric population.en_GB
dc.contributor.departmentCoombe Women and Infants University Hospital, Dolphins Barn, Dublin 8, Ireland.en_GB
dc.identifier.journalHuman reproduction (Oxford, England)en_GB
dc.description.provinceLeinster-
All Items in Lenus, The Irish Health Repository are protected by copyright, with all rights reserved, unless otherwise indicated.