Methadone and perinatal outcomes: a retrospective cohort study.

Hdl Handle:
http://hdl.handle.net/10147/208001
Title:
Methadone and perinatal outcomes: a retrospective cohort study.
Authors:
Cleary, Brian J; Donnelly, Jean M; Strawbridge, Judith D; Gallagher, Paul J; Fahey, Tom; White, Martin J; Murphy, Deirdre J
Affiliation:
Department of Obstetrics and Gynecology, Trinity College Dublin, Royal College of, Surgeons in Ireland, Dublin, Republic of Ireland. bcleary@coombe.ie
Citation:
Am J Obstet Gynecol. 2011 Feb;204(2):139.e1-9. Epub 2010 Dec 8.
Journal:
American journal of obstetrics and gynecology
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/208001
DOI:
10.1016/j.ajog.2010.10.004
PubMed ID:
21145035
Abstract:
OBJECTIVE: The purpose of this study was to examine the relationship among methadone maintenance treatment, perinatal outcomes, and neonatal abstinence syndrome. STUDY DESIGN: This was a retrospective cohort study of 61,030 singleton births at a large maternity hospital from 2000-2007. RESULTS: There were 618 (1%) women on methadone at delivery. Methadone-exposed women were more likely to be younger, to book late for antenatal care, and to be smokers. Methadone exposure was associated with an increased risk of very preterm birth <32 weeks of gestation (adjusted odds ratio [aOR], 2.47; 95% confidence interval [CI], 1.40-4.34), being small for gestational age <10th percentile (aOR, 3.27; 95% CI, 2.49-4.28), admission to the neonatal unit (aOR, 9.14; 95% CI, 7.21-11.57), and diagnosis of a major congenital anomaly (aOR, 1.94; 95% CI, 1.10-3.43). There was a dose-response relationship between methadone and neonatal abstinence syndrome. CONCLUSION: Methadone exposure is associated with an increased risk of adverse perinatal outcomes, even when known adverse sociodemographic factors have been accounted for. Methadone dose at delivery is 1 of the determinants of neonatal abstinence syndrome.
Language:
eng
MeSH:
Age Factors; Dose-Response Relationship, Drug; Female; Humans; Infant, Newborn; Methadone/*adverse effects/therapeutic use; Narcotics/adverse effects/therapeutic use; Neonatal Abstinence Syndrome/diagnosis/*etiology; Odds Ratio; *Opiate Substitution Treatment; Opioid-Related Disorders/*rehabilitation; Pregnancy; Premature Birth/*etiology; Retrospective Studies; Risk Factors; Smoking; Treatment Outcome
ISSN:
1097-6868 (Electronic); 0002-9378 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorCleary, Brian Jen_GB
dc.contributor.authorDonnelly, Jean Men_GB
dc.contributor.authorStrawbridge, Judith Den_GB
dc.contributor.authorGallagher, Paul Jen_GB
dc.contributor.authorFahey, Tomen_GB
dc.contributor.authorWhite, Martin Jen_GB
dc.contributor.authorMurphy, Deirdre Jen_GB
dc.date.accessioned2012-02-01T10:57:19Z-
dc.date.available2012-02-01T10:57:19Z-
dc.date.issued2012-02-01T10:57:19Z-
dc.identifier.citationAm J Obstet Gynecol. 2011 Feb;204(2):139.e1-9. Epub 2010 Dec 8.en_GB
dc.identifier.issn1097-6868 (Electronic)en_GB
dc.identifier.issn0002-9378 (Linking)en_GB
dc.identifier.pmid21145035en_GB
dc.identifier.doi10.1016/j.ajog.2010.10.004en_GB
dc.identifier.urihttp://hdl.handle.net/10147/208001-
dc.description.abstractOBJECTIVE: The purpose of this study was to examine the relationship among methadone maintenance treatment, perinatal outcomes, and neonatal abstinence syndrome. STUDY DESIGN: This was a retrospective cohort study of 61,030 singleton births at a large maternity hospital from 2000-2007. RESULTS: There were 618 (1%) women on methadone at delivery. Methadone-exposed women were more likely to be younger, to book late for antenatal care, and to be smokers. Methadone exposure was associated with an increased risk of very preterm birth <32 weeks of gestation (adjusted odds ratio [aOR], 2.47; 95% confidence interval [CI], 1.40-4.34), being small for gestational age <10th percentile (aOR, 3.27; 95% CI, 2.49-4.28), admission to the neonatal unit (aOR, 9.14; 95% CI, 7.21-11.57), and diagnosis of a major congenital anomaly (aOR, 1.94; 95% CI, 1.10-3.43). There was a dose-response relationship between methadone and neonatal abstinence syndrome. CONCLUSION: Methadone exposure is associated with an increased risk of adverse perinatal outcomes, even when known adverse sociodemographic factors have been accounted for. Methadone dose at delivery is 1 of the determinants of neonatal abstinence syndrome.en_GB
dc.language.isoengen_GB
dc.subject.meshAge Factorsen_GB
dc.subject.meshDose-Response Relationship, Drugen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshInfant, Newbornen_GB
dc.subject.meshMethadone/*adverse effects/therapeutic useen_GB
dc.subject.meshNarcotics/adverse effects/therapeutic useen_GB
dc.subject.meshNeonatal Abstinence Syndrome/diagnosis/*etiologyen_GB
dc.subject.meshOdds Ratioen_GB
dc.subject.mesh*Opiate Substitution Treatmenten_GB
dc.subject.meshOpioid-Related Disorders/*rehabilitationen_GB
dc.subject.meshPregnancyen_GB
dc.subject.meshPremature Birth/*etiologyen_GB
dc.subject.meshRetrospective Studiesen_GB
dc.subject.meshRisk Factorsen_GB
dc.subject.meshSmokingen_GB
dc.subject.meshTreatment Outcomeen_GB
dc.titleMethadone and perinatal outcomes: a retrospective cohort study.en_GB
dc.contributor.departmentDepartment of Obstetrics and Gynecology, Trinity College Dublin, Royal College of, Surgeons in Ireland, Dublin, Republic of Ireland. bcleary@coombe.ieen_GB
dc.identifier.journalAmerican journal of obstetrics and gynecologyen_GB
dc.description.provinceLeinster-

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