Psychophysical function in age-related maculopathy.

Hdl Handle:
http://hdl.handle.net/10147/207968
Title:
Psychophysical function in age-related maculopathy.
Authors:
Neelam, Kumari; Nolan, John; Chakravarthy, Usha; Beatty, Stephen
Affiliation:
Waterford Institute of Technology, Waterford Regional Hospital, Waterford,, Republic of Ireland. Kumari.neelam@Alexhosp.com.sg
Citation:
Surv Ophthalmol. 2009 Mar-Apr;54(2):167-210.
Journal:
Survey of ophthalmology
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207968
DOI:
10.1016/j.survophthal.2008.12.003
PubMed ID:
19298899
Abstract:
Age-related macular degeneration (AMD), the late stage of age-related maculopathy (ARM), is the leading cause of blind registration in developed countries. The visual loss in AMD occurs due to dysfunction and death of photoreceptors (rods and cones) secondary to an atrophic or a neovascular event. The psychophysical tests of vision, which depend on the functional status of the photoreceptors, may detect subtle alterations in the macula before morphological fundus changes are apparent ophthalmoscopically, and before traditional measures of visual acuity exhibit deterioration, and may be a useful tool for assessing and monitoring patients with ARM. Furthermore, worsening of these visual functions over time may reflect disease progression, and some of these, alone or in combination with other parameters, may act as a prognostic indicator for identifying eyes at risk for developing neovascular AMD. Lastly, psychophysical tests often correlate with subjective and relatively undefined symptoms in patients with early ARM, and may reflect limitation of daily activities for ARM patients. However, clinical studies investigating psychophysical function have largely been cross-sectional in nature, with small sample sizes, and lack consistency in terms of the grading and classification of ARM. This article aims to comprehensively review the literature germane to psychophysical tests in ARM, and to furnish the reader with an insight into this complex area of research.
Language:
eng
MeSH:
Adaptation, Ocular/physiology; Humans; Macular Degeneration/*physiopathology; Photoreceptor Cells, Vertebrate/*physiology; *Psychophysics; Visual Field Tests; Visual Perception/*physiology
ISSN:
0039-6257 (Print); 0039-6257 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorNeelam, Kumarien_GB
dc.contributor.authorNolan, Johnen_GB
dc.contributor.authorChakravarthy, Ushaen_GB
dc.contributor.authorBeatty, Stephenen_GB
dc.date.accessioned2012-02-01T10:52:51Z-
dc.date.available2012-02-01T10:52:51Z-
dc.date.issued2012-02-01T10:52:51Z-
dc.identifier.citationSurv Ophthalmol. 2009 Mar-Apr;54(2):167-210.en_GB
dc.identifier.issn0039-6257 (Print)en_GB
dc.identifier.issn0039-6257 (Linking)en_GB
dc.identifier.pmid19298899en_GB
dc.identifier.doi10.1016/j.survophthal.2008.12.003en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207968-
dc.description.abstractAge-related macular degeneration (AMD), the late stage of age-related maculopathy (ARM), is the leading cause of blind registration in developed countries. The visual loss in AMD occurs due to dysfunction and death of photoreceptors (rods and cones) secondary to an atrophic or a neovascular event. The psychophysical tests of vision, which depend on the functional status of the photoreceptors, may detect subtle alterations in the macula before morphological fundus changes are apparent ophthalmoscopically, and before traditional measures of visual acuity exhibit deterioration, and may be a useful tool for assessing and monitoring patients with ARM. Furthermore, worsening of these visual functions over time may reflect disease progression, and some of these, alone or in combination with other parameters, may act as a prognostic indicator for identifying eyes at risk for developing neovascular AMD. Lastly, psychophysical tests often correlate with subjective and relatively undefined symptoms in patients with early ARM, and may reflect limitation of daily activities for ARM patients. However, clinical studies investigating psychophysical function have largely been cross-sectional in nature, with small sample sizes, and lack consistency in terms of the grading and classification of ARM. This article aims to comprehensively review the literature germane to psychophysical tests in ARM, and to furnish the reader with an insight into this complex area of research.en_GB
dc.language.isoengen_GB
dc.subject.meshAdaptation, Ocular/physiologyen_GB
dc.subject.meshHumansen_GB
dc.subject.meshMacular Degeneration/*physiopathologyen_GB
dc.subject.meshPhotoreceptor Cells, Vertebrate/*physiologyen_GB
dc.subject.mesh*Psychophysicsen_GB
dc.subject.meshVisual Field Testsen_GB
dc.subject.meshVisual Perception/*physiologyen_GB
dc.titlePsychophysical function in age-related maculopathy.en_GB
dc.contributor.departmentWaterford Institute of Technology, Waterford Regional Hospital, Waterford,, Republic of Ireland. Kumari.neelam@Alexhosp.com.sgen_GB
dc.identifier.journalSurvey of ophthalmologyen_GB
dc.description.provinceMunster-

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