Nosocomial outbreak of hepatitis B virus infection involving two hospitals in the Republic of Ireland.

Hdl Handle:
http://hdl.handle.net/10147/207959
Title:
Nosocomial outbreak of hepatitis B virus infection involving two hospitals in the Republic of Ireland.
Authors:
Burns, K; Heslin, J; Crowley, B; Thornton, L; Laoi, B Ni; Kelly, E; Ward, E; Doody, B; Hickey, M M
Affiliation:
Department of Clinical Microbiology, Waterford Regional Hospital, Waterford,, Ireland. burnskaren@yahoo.co.uk
Citation:
J Hosp Infect. 2011 Aug;78(4):279-83. Epub 2011 May 6.
Journal:
The Journal of hospital infection
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207959
DOI:
10.1016/j.jhin.2011.02.016
PubMed ID:
21530000
Abstract:
The routes of nosocomial hepatitis B virus (HBV) transmission have changed over the years. Initiatives to prevent transfusion-associated HBV and healthcare worker-to-patient transmission have had a positive impact on these transmission routes. Recent reports of outbreaks of nosocomial HBV have implicated breaches in standard precautions as important causes of HBV transmission. This report describes a nosocomial outbreak of HBV infection in the Republic of Ireland, which occurred between January 2005 and March 2006. The outbreak was detected following identification of a case of acute HBV infection in a patient whose only risk factor was a recent surgical procedure. The extensive multi-agency investigation that followed revealed that the patient was one of five cases of acute HBV infection and that four separate transmission events between infectious cases had occurred in two different hospitals over a 15-month period. A definitive cause for each transmission event was not identified, although lapses in adherence to standard precautions, safe injection and phlebotomy practices could not be ruled out. Two secondary cases of acute HBV infection in community contacts of two of the nosocomial cases were identified. Phylogenetic analysis proved a useful tool in confirming infection with a pre-core HBV mutant and viral transmission between the seven patients. A patient notification exercise involving 1028 potentially exposed patients found no evidence of additional cases of nosocomial HBV infection. These findings highlight the importance of consistent application of standard precautions.
Language:
eng
MeSH:
Adult; Aged; Cluster Analysis; Cross Infection/*epidemiology/virology; DNA, Viral/genetics; *Disease Outbreaks; Hepatitis B/*epidemiology/virology; Hepatitis B virus/classification/genetics/*isolation & purification; Humans; Ireland/epidemiology; Middle Aged; Phylogeny
ISSN:
1532-2939 (Electronic); 0195-6701 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorBurns, Ken_GB
dc.contributor.authorHeslin, Jen_GB
dc.contributor.authorCrowley, Ben_GB
dc.contributor.authorThornton, Len_GB
dc.contributor.authorLaoi, B Nien_GB
dc.contributor.authorKelly, Een_GB
dc.contributor.authorWard, Een_GB
dc.contributor.authorDoody, Ben_GB
dc.contributor.authorHickey, M Men_GB
dc.date.accessioned2012-02-01T10:52:36Z-
dc.date.available2012-02-01T10:52:36Z-
dc.date.issued2012-02-01T10:52:36Z-
dc.identifier.citationJ Hosp Infect. 2011 Aug;78(4):279-83. Epub 2011 May 6.en_GB
dc.identifier.issn1532-2939 (Electronic)en_GB
dc.identifier.issn0195-6701 (Linking)en_GB
dc.identifier.pmid21530000en_GB
dc.identifier.doi10.1016/j.jhin.2011.02.016en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207959-
dc.description.abstractThe routes of nosocomial hepatitis B virus (HBV) transmission have changed over the years. Initiatives to prevent transfusion-associated HBV and healthcare worker-to-patient transmission have had a positive impact on these transmission routes. Recent reports of outbreaks of nosocomial HBV have implicated breaches in standard precautions as important causes of HBV transmission. This report describes a nosocomial outbreak of HBV infection in the Republic of Ireland, which occurred between January 2005 and March 2006. The outbreak was detected following identification of a case of acute HBV infection in a patient whose only risk factor was a recent surgical procedure. The extensive multi-agency investigation that followed revealed that the patient was one of five cases of acute HBV infection and that four separate transmission events between infectious cases had occurred in two different hospitals over a 15-month period. A definitive cause for each transmission event was not identified, although lapses in adherence to standard precautions, safe injection and phlebotomy practices could not be ruled out. Two secondary cases of acute HBV infection in community contacts of two of the nosocomial cases were identified. Phylogenetic analysis proved a useful tool in confirming infection with a pre-core HBV mutant and viral transmission between the seven patients. A patient notification exercise involving 1028 potentially exposed patients found no evidence of additional cases of nosocomial HBV infection. These findings highlight the importance of consistent application of standard precautions.en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAgeden_GB
dc.subject.meshCluster Analysisen_GB
dc.subject.meshCross Infection/*epidemiology/virologyen_GB
dc.subject.meshDNA, Viral/geneticsen_GB
dc.subject.mesh*Disease Outbreaksen_GB
dc.subject.meshHepatitis B/*epidemiology/virologyen_GB
dc.subject.meshHepatitis B virus/classification/genetics/*isolation & purificationen_GB
dc.subject.meshHumansen_GB
dc.subject.meshIreland/epidemiologyen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshPhylogenyen_GB
dc.titleNosocomial outbreak of hepatitis B virus infection involving two hospitals in the Republic of Ireland.en_GB
dc.contributor.departmentDepartment of Clinical Microbiology, Waterford Regional Hospital, Waterford,, Ireland. burnskaren@yahoo.co.uken_GB
dc.identifier.journalThe Journal of hospital infectionen_GB
dc.description.provinceMunster-

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