Hdl Handle:
http://hdl.handle.net/10147/207958
Title:
Risk factors for age-related maculopathy.
Authors:
Connell, Paul P; Keane, Pearse A; O'Neill, Evelyn C; Altaie, Rasha W; Loane, Edward; Neelam, Kumari; Nolan, John M; Beatty, Stephen
Affiliation:
Waterford Regional Hospital, Dunmore Road, Waterford, Ireland.
Citation:
J Ophthalmol. 2009;2009:360764. Epub 2009 Sep 6.
Journal:
Journal of ophthalmology
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207958
DOI:
10.1155/2009/360764
PubMed ID:
20339564
Abstract:
Age-related maculopathy (ARM) is the leading cause of blindness in the elderly. Although beneficial therapeutic strategies have recently begun to emerge, much remains unclear regarding the etiopathogenesis of this disorder. Epidemiologic studies have enhanced our understanding of ARM, but the data, often conflicting, has led to difficulties with drawing firm conclusions with respect to risk for this condition. As a consequence, we saw a need to assimilate the published findings with respect to risk factors for ARM, through a review of the literature appraising results from published cross-sectional studies, prospective cohort studies, case series, and case control studies investigating risk for this condition. Our review shows that, to date, and across a spectrum of epidemiologic study designs, only age, cigarette smoking, and family history of ARM have been consistently demonstrated to represent risk for this condition. In addition, genetic studies have recently implicated many genes in the pathogenesis of age-related maculopathy, including Complement Factor H, PLEKHA 1, and LOC387715/HTRA1, demonstrating that environmental and genetic factors are important for the development of ARM suggesting that gene-environment interaction plays an important role in the pathogenesis of this condition.
Language:
eng
ISSN:
2090-0058 (Electronic); 2090-004X (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorConnell, Paul Pen_GB
dc.contributor.authorKeane, Pearse Aen_GB
dc.contributor.authorO'Neill, Evelyn Cen_GB
dc.contributor.authorAltaie, Rasha Wen_GB
dc.contributor.authorLoane, Edwarden_GB
dc.contributor.authorNeelam, Kumarien_GB
dc.contributor.authorNolan, John Men_GB
dc.contributor.authorBeatty, Stephenen_GB
dc.date.accessioned2012-02-01T10:52:34Z-
dc.date.available2012-02-01T10:52:34Z-
dc.date.issued2012-02-01T10:52:34Z-
dc.identifier.citationJ Ophthalmol. 2009;2009:360764. Epub 2009 Sep 6.en_GB
dc.identifier.issn2090-0058 (Electronic)en_GB
dc.identifier.issn2090-004X (Linking)en_GB
dc.identifier.pmid20339564en_GB
dc.identifier.doi10.1155/2009/360764en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207958-
dc.description.abstractAge-related maculopathy (ARM) is the leading cause of blindness in the elderly. Although beneficial therapeutic strategies have recently begun to emerge, much remains unclear regarding the etiopathogenesis of this disorder. Epidemiologic studies have enhanced our understanding of ARM, but the data, often conflicting, has led to difficulties with drawing firm conclusions with respect to risk for this condition. As a consequence, we saw a need to assimilate the published findings with respect to risk factors for ARM, through a review of the literature appraising results from published cross-sectional studies, prospective cohort studies, case series, and case control studies investigating risk for this condition. Our review shows that, to date, and across a spectrum of epidemiologic study designs, only age, cigarette smoking, and family history of ARM have been consistently demonstrated to represent risk for this condition. In addition, genetic studies have recently implicated many genes in the pathogenesis of age-related maculopathy, including Complement Factor H, PLEKHA 1, and LOC387715/HTRA1, demonstrating that environmental and genetic factors are important for the development of ARM suggesting that gene-environment interaction plays an important role in the pathogenesis of this condition.en_GB
dc.language.isoengen_GB
dc.titleRisk factors for age-related maculopathy.en_GB
dc.contributor.departmentWaterford Regional Hospital, Dunmore Road, Waterford, Ireland.en_GB
dc.identifier.journalJournal of ophthalmologyen_GB
dc.description.provinceMunster-

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