A comparative study of renal dysfunction in patients with inflammatory arthropathies: strong association with cardiovascular diseases and not with anti-rheumatic therapies, inflammatory markers or duration of arthritis.

Hdl Handle:
http://hdl.handle.net/10147/207948
Title:
A comparative study of renal dysfunction in patients with inflammatory arthropathies: strong association with cardiovascular diseases and not with anti-rheumatic therapies, inflammatory markers or duration of arthritis.
Authors:
Haroon, Muhammad; Adeeb, Fahd; Devlin, Joe; O Gradaigh, Donncha; Walker, Frank
Affiliation:
Department of Rheumatology, Waterford Regional Hospital, Waterford, Ireland., mharoon301@hotmail.com
Citation:
Int J Rheum Dis. 2011 Aug;14(3):255-60. doi: 10.1111/j.1756-185X.2011.01594.x., Epub 2011 Apr 4.
Journal:
International journal of rheumatic diseases
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207948
DOI:
10.1111/j.1756-185X.2011.01594.x
PubMed ID:
21816021
Abstract:
AIMS: The aim of this study was to investigate the prevalence of chronic kidney disease (CKD) among comparable patients with rheumatoid arthritis (RA) and seronegative inflammatory arthritis, and to explore any predictive factors for renal impairment. METHODS: Consecutive patients with peripheral joint disease (oligo and polyarthritis) were recruited from our inflammatory arthritis clinics. We divided patients in two groups: RA group and seronegative inflammatory arthritis group. The cohort consisted of 183 patients (RA = 107, seronegative arthritis = 76 [psoriatic arthritis = 69, undifferentiated oligoarthritis = 7]). Estimated glomerular filtration rate (eGFR) was calculated using the established Modification of Diet in Renal Disease equation. Demographic details, disease-specific characteristics, anti-rheumatic drugs and the presence of cardiovascular diseases were recorded. RESULTS: In total, 17.48% (n = 32) of the cohort had CKD. There was no statistically significant variation between the two groups as regards baseline demographics, disease characteristics, use of anti-rheumatic drugs and the presence of individual cardiovascular diseases. We found that eGFR and the presence of CKD were similar among these groups. Among patients with CKD, 72% had undiagnosed CKD. No association of statistical significance was noted between CKD and the use of corticosteroids, disease-modifying antirheumatic drugs and anti-tumor necrosis factor agents. The association of cardiovascular diseases with CKD remained significant after adjusting for confounders (age, gender, duration of arthritis, high C-reactive protein, use of anti-rheumatic drugs). CONCLUSIONS: Patients with inflammatory arthritis are more prone to have CKD. This could have serious implications, as the majority of rheumatology patients use non-steroidal anti-inflammatory drugs and different immunosuppressives, such as methotrexate. No association of kidney dysfunction was noted with inflammatory disease-specific characteristics; rather it appears to have a positive independent association with cardiovascular diseases.
Language:
eng
MeSH:
Antirheumatic Agents; Arthritis/blood/*epidemiology; Arthritis, Psoriatic/blood/diagnosis/epidemiology; Arthritis, Rheumatoid/blood/diagnosis/epidemiology; Biological Markers/blood; C-Reactive Protein; Cardiovascular Diseases/blood/diagnosis/*epidemiology; Cohort Studies; Comorbidity; Female; Glomerular Filtration Rate; Humans; Ireland/epidemiology; Male; Middle Aged; Renal Insufficiency, Chronic/blood/diagnosis/*epidemiology
ISSN:
1756-185X (Electronic); 1756-1841 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorHaroon, Muhammaden_GB
dc.contributor.authorAdeeb, Fahden_GB
dc.contributor.authorDevlin, Joeen_GB
dc.contributor.authorO Gradaigh, Donnchaen_GB
dc.contributor.authorWalker, Franken_GB
dc.date.accessioned2012-02-01T10:52:16Z-
dc.date.available2012-02-01T10:52:16Z-
dc.date.issued2012-02-01T10:52:16Z-
dc.identifier.citationInt J Rheum Dis. 2011 Aug;14(3):255-60. doi: 10.1111/j.1756-185X.2011.01594.x., Epub 2011 Apr 4.en_GB
dc.identifier.issn1756-185X (Electronic)en_GB
dc.identifier.issn1756-1841 (Linking)en_GB
dc.identifier.pmid21816021en_GB
dc.identifier.doi10.1111/j.1756-185X.2011.01594.xen_GB
dc.identifier.urihttp://hdl.handle.net/10147/207948-
dc.description.abstractAIMS: The aim of this study was to investigate the prevalence of chronic kidney disease (CKD) among comparable patients with rheumatoid arthritis (RA) and seronegative inflammatory arthritis, and to explore any predictive factors for renal impairment. METHODS: Consecutive patients with peripheral joint disease (oligo and polyarthritis) were recruited from our inflammatory arthritis clinics. We divided patients in two groups: RA group and seronegative inflammatory arthritis group. The cohort consisted of 183 patients (RA = 107, seronegative arthritis = 76 [psoriatic arthritis = 69, undifferentiated oligoarthritis = 7]). Estimated glomerular filtration rate (eGFR) was calculated using the established Modification of Diet in Renal Disease equation. Demographic details, disease-specific characteristics, anti-rheumatic drugs and the presence of cardiovascular diseases were recorded. RESULTS: In total, 17.48% (n = 32) of the cohort had CKD. There was no statistically significant variation between the two groups as regards baseline demographics, disease characteristics, use of anti-rheumatic drugs and the presence of individual cardiovascular diseases. We found that eGFR and the presence of CKD were similar among these groups. Among patients with CKD, 72% had undiagnosed CKD. No association of statistical significance was noted between CKD and the use of corticosteroids, disease-modifying antirheumatic drugs and anti-tumor necrosis factor agents. The association of cardiovascular diseases with CKD remained significant after adjusting for confounders (age, gender, duration of arthritis, high C-reactive protein, use of anti-rheumatic drugs). CONCLUSIONS: Patients with inflammatory arthritis are more prone to have CKD. This could have serious implications, as the majority of rheumatology patients use non-steroidal anti-inflammatory drugs and different immunosuppressives, such as methotrexate. No association of kidney dysfunction was noted with inflammatory disease-specific characteristics; rather it appears to have a positive independent association with cardiovascular diseases.en_GB
dc.language.isoengen_GB
dc.subject.meshAntirheumatic Agentsen_GB
dc.subject.meshArthritis/blood/*epidemiologyen_GB
dc.subject.meshArthritis, Psoriatic/blood/diagnosis/epidemiologyen_GB
dc.subject.meshArthritis, Rheumatoid/blood/diagnosis/epidemiologyen_GB
dc.subject.meshBiological Markers/blooden_GB
dc.subject.meshC-Reactive Proteinen_GB
dc.subject.meshCardiovascular Diseases/blood/diagnosis/*epidemiologyen_GB
dc.subject.meshCohort Studiesen_GB
dc.subject.meshComorbidityen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshGlomerular Filtration Rateen_GB
dc.subject.meshHumansen_GB
dc.subject.meshIreland/epidemiologyen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshRenal Insufficiency, Chronic/blood/diagnosis/*epidemiologyen_GB
dc.titleA comparative study of renal dysfunction in patients with inflammatory arthropathies: strong association with cardiovascular diseases and not with anti-rheumatic therapies, inflammatory markers or duration of arthritis.en_GB
dc.contributor.departmentDepartment of Rheumatology, Waterford Regional Hospital, Waterford, Ireland., mharoon301@hotmail.comen_GB
dc.identifier.journalInternational journal of rheumatic diseasesen_GB
dc.description.provinceMunster-

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