A rare case of thyroid metastasis from pancreatic adenocarcinoma.

Hdl Handle:
http://hdl.handle.net/10147/207926
Title:
A rare case of thyroid metastasis from pancreatic adenocarcinoma.
Authors:
Kelly, Michael E; Kinsella, John; d'Adhemar, Charles; Swan, Niall; Ridgway, Paul F
Affiliation:
Professorial Surgical Unit, Department of Surgery, The Adelaide and Meath, Hospital, Dublin Incorporating the National Children's Hospital Dublin, Ireland. , kellym11@tcd.ie
Citation:
JOP. 2011 Jan 5;12(1):37-9.
Journal:
JOP : Journal of the pancreas
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207926
PubMed ID:
21206099
Abstract:
CONTEXT: Thyroid metastasis from pancreatic adenocarcinoma is extremely rare, with only two previous cases in the literature. We report a case of pancreatic adenocarcinoma metastasising to the thyroid. We review the incidence, diagnosis, and management of this rare occurrence. CASE REPORT: A 38-year-old man with a synchronous 6-month history of thyroid swelling, presented with epigastric pain and signs of obstructive jaundice. He was investigated by abdominal computerised tomography and endoscopic retrograde cholangiopancreatography. The diagnosis of pancreatic neoplasm was made. His thyroid neoplasm was investigated at another tertiary centre and thought to be a papillary neoplasm. He underwent a pancreaticoduodenectomy and recovered well post-operatively. Eight weeks later he had a total thyroidectomy. Histology confirmed that the thyroid mass was both morphologically and immunophenotypically similar to the pancreatic neoplasm. CONCLUSION: This case demonstrates the importance of a full investigation when a patient with suspected neoplastic history presents with a thyroid nodule. We outline the crucial role that immunohistochemistry plays in detecting and classifying primary and secondary thyroid neoplasms. The detection of a solitary thyroid metastasis from pancreatic adenocarcinoma may indicate a poor prognosis, and it is debatable whether resection of the primary should be undertaken when it presents with a solitary metastasis.
Language:
eng
MeSH:
Adenocarcinoma/*diagnosis/*secondary/therapy; Adult; Antimetabolites, Antineoplastic/therapeutic use; Combined Modality Therapy; Deoxycytidine/analogs & derivatives/therapeutic use; Humans; Male; Palliative Care; Pancreatic Neoplasms/drug therapy/*pathology/surgery; Pancreaticoduodenectomy; Thyroid Neoplasms/*diagnosis/*secondary/therapy; Thyroidectomy; Treatment Outcome
ISSN:
1590-8577 (Electronic); 1590-8577 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorKelly, Michael Een_GB
dc.contributor.authorKinsella, Johnen_GB
dc.contributor.authord'Adhemar, Charlesen_GB
dc.contributor.authorSwan, Niallen_GB
dc.contributor.authorRidgway, Paul Fen_GB
dc.date.accessioned2012-02-01T10:50:18Z-
dc.date.available2012-02-01T10:50:18Z-
dc.date.issued2012-02-01T10:50:18Z-
dc.identifier.citationJOP. 2011 Jan 5;12(1):37-9.en_GB
dc.identifier.issn1590-8577 (Electronic)en_GB
dc.identifier.issn1590-8577 (Linking)en_GB
dc.identifier.pmid21206099en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207926-
dc.description.abstractCONTEXT: Thyroid metastasis from pancreatic adenocarcinoma is extremely rare, with only two previous cases in the literature. We report a case of pancreatic adenocarcinoma metastasising to the thyroid. We review the incidence, diagnosis, and management of this rare occurrence. CASE REPORT: A 38-year-old man with a synchronous 6-month history of thyroid swelling, presented with epigastric pain and signs of obstructive jaundice. He was investigated by abdominal computerised tomography and endoscopic retrograde cholangiopancreatography. The diagnosis of pancreatic neoplasm was made. His thyroid neoplasm was investigated at another tertiary centre and thought to be a papillary neoplasm. He underwent a pancreaticoduodenectomy and recovered well post-operatively. Eight weeks later he had a total thyroidectomy. Histology confirmed that the thyroid mass was both morphologically and immunophenotypically similar to the pancreatic neoplasm. CONCLUSION: This case demonstrates the importance of a full investigation when a patient with suspected neoplastic history presents with a thyroid nodule. We outline the crucial role that immunohistochemistry plays in detecting and classifying primary and secondary thyroid neoplasms. The detection of a solitary thyroid metastasis from pancreatic adenocarcinoma may indicate a poor prognosis, and it is debatable whether resection of the primary should be undertaken when it presents with a solitary metastasis.en_GB
dc.language.isoengen_GB
dc.subject.meshAdenocarcinoma/*diagnosis/*secondary/therapyen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAntimetabolites, Antineoplastic/therapeutic useen_GB
dc.subject.meshCombined Modality Therapyen_GB
dc.subject.meshDeoxycytidine/analogs & derivatives/therapeutic useen_GB
dc.subject.meshHumansen_GB
dc.subject.meshMaleen_GB
dc.subject.meshPalliative Careen_GB
dc.subject.meshPancreatic Neoplasms/drug therapy/*pathology/surgeryen_GB
dc.subject.meshPancreaticoduodenectomyen_GB
dc.subject.meshThyroid Neoplasms/*diagnosis/*secondary/therapyen_GB
dc.subject.meshThyroidectomyen_GB
dc.subject.meshTreatment Outcomeen_GB
dc.titleA rare case of thyroid metastasis from pancreatic adenocarcinoma.en_GB
dc.contributor.departmentProfessorial Surgical Unit, Department of Surgery, The Adelaide and Meath, Hospital, Dublin Incorporating the National Children's Hospital Dublin, Ireland. , kellym11@tcd.ieen_GB
dc.identifier.journalJOP : Journal of the pancreasen_GB
dc.description.provinceLeinster-

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