A rare case of thyroid metastasis from pancreatic adenocarcinoma.
Affiliation
Professorial Surgical Unit, Department of Surgery, The Adelaide and Meath, Hospital, Dublin Incorporating the National Children's Hospital Dublin, Ireland. , kellym11@tcd.ieIssue Date
2012-02-01T10:50:18ZMeSH
Adenocarcinoma/*diagnosis/*secondary/therapyAdult
Antimetabolites, Antineoplastic/therapeutic use
Combined Modality Therapy
Deoxycytidine/analogs & derivatives/therapeutic use
Humans
Male
Palliative Care
Pancreatic Neoplasms/drug therapy/*pathology/surgery
Pancreaticoduodenectomy
Thyroid Neoplasms/*diagnosis/*secondary/therapy
Thyroidectomy
Treatment Outcome
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Show full item recordCitation
JOP. 2011 Jan 5;12(1):37-9.Journal
JOP : Journal of the pancreasPubMed ID
21206099Abstract
CONTEXT: Thyroid metastasis from pancreatic adenocarcinoma is extremely rare, with only two previous cases in the literature. We report a case of pancreatic adenocarcinoma metastasising to the thyroid. We review the incidence, diagnosis, and management of this rare occurrence. CASE REPORT: A 38-year-old man with a synchronous 6-month history of thyroid swelling, presented with epigastric pain and signs of obstructive jaundice. He was investigated by abdominal computerised tomography and endoscopic retrograde cholangiopancreatography. The diagnosis of pancreatic neoplasm was made. His thyroid neoplasm was investigated at another tertiary centre and thought to be a papillary neoplasm. He underwent a pancreaticoduodenectomy and recovered well post-operatively. Eight weeks later he had a total thyroidectomy. Histology confirmed that the thyroid mass was both morphologically and immunophenotypically similar to the pancreatic neoplasm. CONCLUSION: This case demonstrates the importance of a full investigation when a patient with suspected neoplastic history presents with a thyroid nodule. We outline the crucial role that immunohistochemistry plays in detecting and classifying primary and secondary thyroid neoplasms. The detection of a solitary thyroid metastasis from pancreatic adenocarcinoma may indicate a poor prognosis, and it is debatable whether resection of the primary should be undertaken when it presents with a solitary metastasis.Language
engISSN
1590-8577 (Electronic)1590-8577 (Linking)
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