Homocysteine status and cardiovascular risk factors in patients with psoriasis: a case-control study.

Hdl Handle:
http://hdl.handle.net/10147/207921
Title:
Homocysteine status and cardiovascular risk factors in patients with psoriasis: a case-control study.
Authors:
Tobin, A-M; Hughes, R; Hand, E B; Leong, T; Graham, I M; Kirby, B
Affiliation:
Department of Dermatology, Adelaide and Meath Hospital incorporating National, Children's Hospital, Tallaght, Dublin, Ireland.
Citation:
Clin Exp Dermatol. 2011 Jan;36(1):19-23. doi: 10.1111/j.1365-2230.2010.03877.x.
Journal:
Clinical and experimental dermatology
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207921
DOI:
10.1111/j.1365-2230.2010.03877.x
PubMed ID:
20545954
Abstract:
BACKGROUND: Psoriasis is a hyperproliferative, cutaneous disorder with the potential to lower levels of folate. This may result in raised levels of homocysteine, an independent risk factor for the development of cardiovascular disease. OBJECTIVE: A study was conducted to compare levels of red-cell folate (RCF) and homocysteine in patients with psoriasis and in healthy controls. Levels of homocysteine were also examined in the context of other major cardiovascular risk factors. METHODS: In total, 20 patients with psoriasis and 20 controls had their RCF, homo-cysteine and other conventional cardiovascular risk factors assessed. RESULTS: Patients with psoriasis had a trend towards lower levels of RCF. Significantly raised levels of homocysteine were found in patients with psoriasis compared with controls (P = 0.007). There was no correlation between homocysteine levels, RCF levels or disease activity as measured by the Psoriasis Area and Severity Index. Patients with psoriasis had higher body mass index (P < 0.004) and higher systolic blood pressure (P < 0.001) than controls. This may contribute to the excess cardiovascular mortality observed in patients with psoriasis.
Language:
eng
MeSH:
Adult; Aged; Cardiovascular Diseases/blood/*etiology; Case-Control Studies; Female; Folic Acid/*blood; Homocysteine/*blood; Humans; Male; Middle Aged; Psoriasis/blood/*complications; Risk Factors; Severity of Illness Index; Vitamin B 12/*blood
ISSN:
1365-2230 (Electronic); 0307-6938 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorTobin, A-Men_GB
dc.contributor.authorHughes, Ren_GB
dc.contributor.authorHand, E Ben_GB
dc.contributor.authorLeong, Ten_GB
dc.contributor.authorGraham, I Men_GB
dc.contributor.authorKirby, Ben_GB
dc.date.accessioned2012-02-01T10:50:09Z-
dc.date.available2012-02-01T10:50:09Z-
dc.date.issued2012-02-01T10:50:09Z-
dc.identifier.citationClin Exp Dermatol. 2011 Jan;36(1):19-23. doi: 10.1111/j.1365-2230.2010.03877.x.en_GB
dc.identifier.issn1365-2230 (Electronic)en_GB
dc.identifier.issn0307-6938 (Linking)en_GB
dc.identifier.pmid20545954en_GB
dc.identifier.doi10.1111/j.1365-2230.2010.03877.xen_GB
dc.identifier.urihttp://hdl.handle.net/10147/207921-
dc.description.abstractBACKGROUND: Psoriasis is a hyperproliferative, cutaneous disorder with the potential to lower levels of folate. This may result in raised levels of homocysteine, an independent risk factor for the development of cardiovascular disease. OBJECTIVE: A study was conducted to compare levels of red-cell folate (RCF) and homocysteine in patients with psoriasis and in healthy controls. Levels of homocysteine were also examined in the context of other major cardiovascular risk factors. METHODS: In total, 20 patients with psoriasis and 20 controls had their RCF, homo-cysteine and other conventional cardiovascular risk factors assessed. RESULTS: Patients with psoriasis had a trend towards lower levels of RCF. Significantly raised levels of homocysteine were found in patients with psoriasis compared with controls (P = 0.007). There was no correlation between homocysteine levels, RCF levels or disease activity as measured by the Psoriasis Area and Severity Index. Patients with psoriasis had higher body mass index (P < 0.004) and higher systolic blood pressure (P < 0.001) than controls. This may contribute to the excess cardiovascular mortality observed in patients with psoriasis.en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAgeden_GB
dc.subject.meshCardiovascular Diseases/blood/*etiologyen_GB
dc.subject.meshCase-Control Studiesen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshFolic Acid/*blooden_GB
dc.subject.meshHomocysteine/*blooden_GB
dc.subject.meshHumansen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshPsoriasis/blood/*complicationsen_GB
dc.subject.meshRisk Factorsen_GB
dc.subject.meshSeverity of Illness Indexen_GB
dc.subject.meshVitamin B 12/*blooden_GB
dc.titleHomocysteine status and cardiovascular risk factors in patients with psoriasis: a case-control study.en_GB
dc.contributor.departmentDepartment of Dermatology, Adelaide and Meath Hospital incorporating National, Children's Hospital, Tallaght, Dublin, Ireland.en_GB
dc.identifier.journalClinical and experimental dermatologyen_GB
dc.description.provinceLeinster-

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