Do we really understand the role of the oesophagogastric junction in disease?

Hdl Handle:
http://hdl.handle.net/10147/207904
Title:
Do we really understand the role of the oesophagogastric junction in disease?
Authors:
McMahon, Barry P; Jobe, Blair A; Pandolfino, John E; Gregersen, Hans
Affiliation:
Department of Medical Physics and Clinical Engineering, Adelaide and Meath, Hospital, Tallaght, Dublin 24, Ireland. barry.mcmahon@tcd.ie
Citation:
World J Gastroenterol. 2009 Jan 14;15(2):144-50.
Journal:
World journal of gastroenterology : WJG
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207904
PubMed ID:
19132763
Abstract:
The role of the oesophago-gastric junction (OGJ) in gastro-oesophageal reflux disease is still not completely understood, and there is no clinically used method to assess the OGJ function in patients. Only indirect methods such as pH studies are carried out. The OGJ acts a valve controlling the flow of solids, liquids and gases between the oesophagus and the stomach. Manometry can determine if a sphincter is toned or relaxed; but, it cannot confirm that the sphincter region is actually open. Distension is a new technique for measuring function in the OGJ. By measuring the cross-sectional area through the narrow region in the junction during distension of a catheter mounted bag, much more information on the opening and closing patterns of the junction can be determined. This technique has already been demonstrated to show changes in the OGJ after surgical treatments for reflux disease. New measurement ideas around the concept of distending the OGJ offer new hope that a clinically useable test for compliance at the junction can be developed and could potentially help in determining appropriate therapy.
Language:
eng
MeSH:
Diagnostic Techniques, Digestive System; Electric Impedance; Esophageal Achalasia/diagnosis/*etiology/physiopathology; Esophagogastric Junction/*physiopathology; Gastroesophageal Reflux/diagnosis/*etiology/physiopathology; Humans; Manometry
ISSN:
1007-9327 (Print); 1007-9327 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorMcMahon, Barry Pen_GB
dc.contributor.authorJobe, Blair Aen_GB
dc.contributor.authorPandolfino, John Een_GB
dc.contributor.authorGregersen, Hansen_GB
dc.date.accessioned2012-02-01T10:49:39Z-
dc.date.available2012-02-01T10:49:39Z-
dc.date.issued2012-02-01T10:49:39Z-
dc.identifier.citationWorld J Gastroenterol. 2009 Jan 14;15(2):144-50.en_GB
dc.identifier.issn1007-9327 (Print)en_GB
dc.identifier.issn1007-9327 (Linking)en_GB
dc.identifier.pmid19132763en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207904-
dc.description.abstractThe role of the oesophago-gastric junction (OGJ) in gastro-oesophageal reflux disease is still not completely understood, and there is no clinically used method to assess the OGJ function in patients. Only indirect methods such as pH studies are carried out. The OGJ acts a valve controlling the flow of solids, liquids and gases between the oesophagus and the stomach. Manometry can determine if a sphincter is toned or relaxed; but, it cannot confirm that the sphincter region is actually open. Distension is a new technique for measuring function in the OGJ. By measuring the cross-sectional area through the narrow region in the junction during distension of a catheter mounted bag, much more information on the opening and closing patterns of the junction can be determined. This technique has already been demonstrated to show changes in the OGJ after surgical treatments for reflux disease. New measurement ideas around the concept of distending the OGJ offer new hope that a clinically useable test for compliance at the junction can be developed and could potentially help in determining appropriate therapy.en_GB
dc.language.isoengen_GB
dc.subject.meshDiagnostic Techniques, Digestive Systemen_GB
dc.subject.meshElectric Impedanceen_GB
dc.subject.meshEsophageal Achalasia/diagnosis/*etiology/physiopathologyen_GB
dc.subject.meshEsophagogastric Junction/*physiopathologyen_GB
dc.subject.meshGastroesophageal Reflux/diagnosis/*etiology/physiopathologyen_GB
dc.subject.meshHumansen_GB
dc.subject.meshManometryen_GB
dc.titleDo we really understand the role of the oesophagogastric junction in disease?en_GB
dc.contributor.departmentDepartment of Medical Physics and Clinical Engineering, Adelaide and Meath, Hospital, Tallaght, Dublin 24, Ireland. barry.mcmahon@tcd.ieen_GB
dc.identifier.journalWorld journal of gastroenterology : WJGen_GB
dc.description.provinceLeinster-

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