Hematological abnormalities in adult patients with Down's syndrome.

Hdl Handle:
http://hdl.handle.net/10147/207892
Title:
Hematological abnormalities in adult patients with Down's syndrome.
Authors:
McLean, S; McHale, C; Enright, H
Affiliation:
Department of Haematology, Adelaide and Meath Hospital, Dublin, Incorporating the, National Children's Hospital, Tallaght, D24, Dublin, Ireland. Smclean81@yahoo.com
Citation:
Ir J Med Sci. 2009 Mar;178(1):35-8. Epub 2008 Nov 20.
Journal:
Irish journal of medical science
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207892
DOI:
10.1007/s11845-008-0223-2
PubMed ID:
19020924
Abstract:
BACKGROUND: There is a paucity of data regarding hematological abnormalities in adults with Down's syndrome (DS). AIMS: We aimed to characterize hematological abnormalities in adult patients with DS and determine their long-term significance. METHODS: We retrospectively studied a cohort of nine DS patients referred to the adult hematology service in our institution between May 2001 and April 2008. Data collected were: full blood count (FBC), comorbidities, investigations performed, duration of follow-up and outcome to most recent follow-up. RESULTS: Median follow-up was 26 months (9-71). Of the nine patients, two had myelodysplastic syndrome (MDS) at presentation. Of these, one progressed, with increasing marrow failure, and requiring support with transfusions and gCSF. The remaining eight patients, with a variety of hematological abnormalities including leukopenia, macrocytosis, and thrombocytopenia, had persistently abnormal FBCs. However there was no evidence of progression, and no patient has evolved to acute myeloid leukemia (AML). CONCLUSIONS: MDS is a complication of DS and may require supportive therapy. However, minor hematological abnormalities are common in adult DS patients, and may not signify underlying marrow disease.
Language:
eng
MeSH:
Adult; Down Syndrome/complications/epidemiology/*physiopathology; Female; Humans; Ireland/epidemiology; Male; Middle Aged; Myelodysplastic Syndromes/epidemiology/etiology/*physiopathology; Retrospective Studies
ISSN:
1863-4362 (Electronic); 0021-1265 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorMcLean, Sen_GB
dc.contributor.authorMcHale, Cen_GB
dc.contributor.authorEnright, Hen_GB
dc.date.accessioned2012-02-01T10:49:19Z-
dc.date.available2012-02-01T10:49:19Z-
dc.date.issued2012-02-01T10:49:19Z-
dc.identifier.citationIr J Med Sci. 2009 Mar;178(1):35-8. Epub 2008 Nov 20.en_GB
dc.identifier.issn1863-4362 (Electronic)en_GB
dc.identifier.issn0021-1265 (Linking)en_GB
dc.identifier.pmid19020924en_GB
dc.identifier.doi10.1007/s11845-008-0223-2en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207892-
dc.description.abstractBACKGROUND: There is a paucity of data regarding hematological abnormalities in adults with Down's syndrome (DS). AIMS: We aimed to characterize hematological abnormalities in adult patients with DS and determine their long-term significance. METHODS: We retrospectively studied a cohort of nine DS patients referred to the adult hematology service in our institution between May 2001 and April 2008. Data collected were: full blood count (FBC), comorbidities, investigations performed, duration of follow-up and outcome to most recent follow-up. RESULTS: Median follow-up was 26 months (9-71). Of the nine patients, two had myelodysplastic syndrome (MDS) at presentation. Of these, one progressed, with increasing marrow failure, and requiring support with transfusions and gCSF. The remaining eight patients, with a variety of hematological abnormalities including leukopenia, macrocytosis, and thrombocytopenia, had persistently abnormal FBCs. However there was no evidence of progression, and no patient has evolved to acute myeloid leukemia (AML). CONCLUSIONS: MDS is a complication of DS and may require supportive therapy. However, minor hematological abnormalities are common in adult DS patients, and may not signify underlying marrow disease.en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshDown Syndrome/complications/epidemiology/*physiopathologyen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshIreland/epidemiologyen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshMyelodysplastic Syndromes/epidemiology/etiology/*physiopathologyen_GB
dc.subject.meshRetrospective Studiesen_GB
dc.titleHematological abnormalities in adult patients with Down's syndrome.en_GB
dc.contributor.departmentDepartment of Haematology, Adelaide and Meath Hospital, Dublin, Incorporating the, National Children's Hospital, Tallaght, D24, Dublin, Ireland. Smclean81@yahoo.comen_GB
dc.identifier.journalIrish journal of medical scienceen_GB
dc.description.provinceLeinster-

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