Lipoprotein subclass patterns in women with polycystic ovary syndrome (PCOS) compared with equally insulin-resistant women without PCOS.

Hdl Handle:
http://hdl.handle.net/10147/207891
Title:
Lipoprotein subclass patterns in women with polycystic ovary syndrome (PCOS) compared with equally insulin-resistant women without PCOS.
Authors:
Phelan, N; O'Connor, A; Kyaw-Tun, T; Correia, N; Boran, G; Roche, H M; Gibney, J
Affiliation:
Department of Endocrinology and Diabetes, Adelaide and Meath Hospital, and School, of Public Health and Population Science, University College Dublin, Dublin 24,, Ireland.
Citation:
J Clin Endocrinol Metab. 2010 Aug;95(8):3933-9. Epub 2010 Jun 2.
Journal:
The Journal of clinical endocrinology and metabolism
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207891
DOI:
10.1210/jc.2009-2444
PubMed ID:
20519354
Abstract:
OBJECTIVES: Women with polycystic ovary syndrome (PCOS) are more insulin resistant and display an atherogenic lipid profile compared with normal women of similar body mass index (BMI). Insulin resistance (IR) at least partially underlies the dyslipidemia of PCOS, but it is unclear whether PCOS status per se confers additional risk. RESEARCH DESIGN AND METHODS: Using a case-control design, we compared plasma lipids and lipoprotein subclasses (using polyacrylamide gel tube electrophoresis) in 70 women with PCOS (National Institutes of Health criteria) and 70 normal women pair matched for age, BMI, and IR (homeostasis model assessment-IR, quantitative insulin sensitivity check index, and the Avignon Index). Subjects were identified as having a (less atherogenic) type A pattern consisting predominantly of large low-density lipoprotein (LDL) subfractions or a (more atherogenic) non-A pattern consisting predominantly of small-dense LDL subfractions. RESULTS: Total, high-density lipoprotein, or LDL cholesterol, or triacylglycerol did not differ between the groups, but very low-density lipoprotein levels (P<0.05) were greater in women with PCOS, whereas a non-A LDL profile was seen in 12.9% compared with 2.9% of controls (P<0.05, chi2). Multiple regression analysis revealed homeostasis model assessment-IR and waist circumference to be independent predictors of very low-density lipoprotein together explaining 40.2% of the overall variance. Logistic regression revealed PCOS status to be the only independent determinant of a non-A LDL pattern (odds ratio 5.48 (95% confidence interval 1.082-27.77; P<0.05). CONCLUSIONS: Compared with women matched for BMI and IR, women with PCOS have potentially important differences in lipid profile with greater very low-density lipoprotein levels and increased rates of a more atherogenic non-A LDL pattern.
Language:
eng
MeSH:
Adult; Body Mass Index; Case-Control Studies; Chi-Square Distribution; Cholesterol/blood; Electrophoresis, Polyacrylamide Gel; Female; Glucose Tolerance Test; Humans; Immunoassay; Insulin/blood; Insulin Resistance/*physiology; Lipoproteins/*blood/classification; Polycystic Ovary Syndrome/*blood; Regression Analysis
ISSN:
1945-7197 (Electronic); 0021-972X (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorPhelan, Nen_GB
dc.contributor.authorO'Connor, Aen_GB
dc.contributor.authorKyaw-Tun, Ten_GB
dc.contributor.authorCorreia, Nen_GB
dc.contributor.authorBoran, Gen_GB
dc.contributor.authorRoche, H Men_GB
dc.contributor.authorGibney, Jen_GB
dc.date.accessioned2012-02-01T10:49:17Z-
dc.date.available2012-02-01T10:49:17Z-
dc.date.issued2012-02-01T10:49:17Z-
dc.identifier.citationJ Clin Endocrinol Metab. 2010 Aug;95(8):3933-9. Epub 2010 Jun 2.en_GB
dc.identifier.issn1945-7197 (Electronic)en_GB
dc.identifier.issn0021-972X (Linking)en_GB
dc.identifier.pmid20519354en_GB
dc.identifier.doi10.1210/jc.2009-2444en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207891-
dc.description.abstractOBJECTIVES: Women with polycystic ovary syndrome (PCOS) are more insulin resistant and display an atherogenic lipid profile compared with normal women of similar body mass index (BMI). Insulin resistance (IR) at least partially underlies the dyslipidemia of PCOS, but it is unclear whether PCOS status per se confers additional risk. RESEARCH DESIGN AND METHODS: Using a case-control design, we compared plasma lipids and lipoprotein subclasses (using polyacrylamide gel tube electrophoresis) in 70 women with PCOS (National Institutes of Health criteria) and 70 normal women pair matched for age, BMI, and IR (homeostasis model assessment-IR, quantitative insulin sensitivity check index, and the Avignon Index). Subjects were identified as having a (less atherogenic) type A pattern consisting predominantly of large low-density lipoprotein (LDL) subfractions or a (more atherogenic) non-A pattern consisting predominantly of small-dense LDL subfractions. RESULTS: Total, high-density lipoprotein, or LDL cholesterol, or triacylglycerol did not differ between the groups, but very low-density lipoprotein levels (P<0.05) were greater in women with PCOS, whereas a non-A LDL profile was seen in 12.9% compared with 2.9% of controls (P<0.05, chi2). Multiple regression analysis revealed homeostasis model assessment-IR and waist circumference to be independent predictors of very low-density lipoprotein together explaining 40.2% of the overall variance. Logistic regression revealed PCOS status to be the only independent determinant of a non-A LDL pattern (odds ratio 5.48 (95% confidence interval 1.082-27.77; P<0.05). CONCLUSIONS: Compared with women matched for BMI and IR, women with PCOS have potentially important differences in lipid profile with greater very low-density lipoprotein levels and increased rates of a more atherogenic non-A LDL pattern.en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshBody Mass Indexen_GB
dc.subject.meshCase-Control Studiesen_GB
dc.subject.meshChi-Square Distributionen_GB
dc.subject.meshCholesterol/blooden_GB
dc.subject.meshElectrophoresis, Polyacrylamide Gelen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshGlucose Tolerance Testen_GB
dc.subject.meshHumansen_GB
dc.subject.meshImmunoassayen_GB
dc.subject.meshInsulin/blooden_GB
dc.subject.meshInsulin Resistance/*physiologyen_GB
dc.subject.meshLipoproteins/*blood/classificationen_GB
dc.subject.meshPolycystic Ovary Syndrome/*blooden_GB
dc.subject.meshRegression Analysisen_GB
dc.titleLipoprotein subclass patterns in women with polycystic ovary syndrome (PCOS) compared with equally insulin-resistant women without PCOS.en_GB
dc.contributor.departmentDepartment of Endocrinology and Diabetes, Adelaide and Meath Hospital, and School, of Public Health and Population Science, University College Dublin, Dublin 24,, Ireland.en_GB
dc.identifier.journalThe Journal of clinical endocrinology and metabolismen_GB
dc.description.provinceLeinster-

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