Neuropsychiatric complications associated with interferon - alpha -2b treatment of malignant melanoma.

Hdl Handle:
http://hdl.handle.net/10147/207886
Title:
Neuropsychiatric complications associated with interferon - alpha -2b treatment of malignant melanoma.
Authors:
Enudi, W; Udolu, O J
Affiliation:
Adelaide and Meath Hospital, Tallaght, Ireland. waltenudi@yahoo.com
Citation:
Afr J Psychiatry (Johannesbg). 2009 Aug;12(3):227-8.
Journal:
African journal of psychiatry
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207886
PubMed ID:
19750253
Abstract:
Several adverse effects have been associated with interferon alpha 2b treatment and neuropsychiatric effects have also been commonly reported. Psychosis and mood disorders have been described in the literature. This case report is of a 30 year old man with malignant melanoma stage 3a who was receiving adjuvant alpha 2b interferon and developed a manic episode two weeks post switching after one month of treatment on a high dose to a low dose. There was no previous psychiatric illness and no known family history of mental illness. This is in keeping with previous reports that mania has been observed in patients undergoing interferon treatment especially after significant dose-reduction or treatment breaks. Mania induced by interferon responds well to antimanic drugs .Since interferon alpha 2b is now commonly used in the treatment of malignant melanoma and other conditions, the need to be aware of its neuropsychiatric complications is essential.
Language:
eng
MeSH:
Adult; Antimanic Agents/therapeutic use; Antineoplastic Agents/*adverse effects/therapeutic use; Antipsychotic Agents/therapeutic use; Benzodiazepines/therapeutic use; Bipolar Disorder/*chemically induced/diagnosis/drug therapy/psychology; Dose-Response Relationship, Drug; Humans; Interferon-alpha/*adverse effects/therapeutic use; Male; Melanoma/*drug therapy; Recombinant Proteins; Skin Neoplasms/*drug therapy
ISSN:
1994-8220 (Print)

Full metadata record

DC FieldValue Language
dc.contributor.authorEnudi, Wen_GB
dc.contributor.authorUdolu, O Jen_GB
dc.date.accessioned2012-02-01T10:49:08Z-
dc.date.available2012-02-01T10:49:08Z-
dc.date.issued2012-02-01T10:49:08Z-
dc.identifier.citationAfr J Psychiatry (Johannesbg). 2009 Aug;12(3):227-8.en_GB
dc.identifier.issn1994-8220 (Print)en_GB
dc.identifier.pmid19750253en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207886-
dc.description.abstractSeveral adverse effects have been associated with interferon alpha 2b treatment and neuropsychiatric effects have also been commonly reported. Psychosis and mood disorders have been described in the literature. This case report is of a 30 year old man with malignant melanoma stage 3a who was receiving adjuvant alpha 2b interferon and developed a manic episode two weeks post switching after one month of treatment on a high dose to a low dose. There was no previous psychiatric illness and no known family history of mental illness. This is in keeping with previous reports that mania has been observed in patients undergoing interferon treatment especially after significant dose-reduction or treatment breaks. Mania induced by interferon responds well to antimanic drugs .Since interferon alpha 2b is now commonly used in the treatment of malignant melanoma and other conditions, the need to be aware of its neuropsychiatric complications is essential.en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAntimanic Agents/therapeutic useen_GB
dc.subject.meshAntineoplastic Agents/*adverse effects/therapeutic useen_GB
dc.subject.meshAntipsychotic Agents/therapeutic useen_GB
dc.subject.meshBenzodiazepines/therapeutic useen_GB
dc.subject.meshBipolar Disorder/*chemically induced/diagnosis/drug therapy/psychologyen_GB
dc.subject.meshDose-Response Relationship, Drugen_GB
dc.subject.meshHumansen_GB
dc.subject.meshInterferon-alpha/*adverse effects/therapeutic useen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMelanoma/*drug therapyen_GB
dc.subject.meshRecombinant Proteinsen_GB
dc.subject.meshSkin Neoplasms/*drug therapyen_GB
dc.titleNeuropsychiatric complications associated with interferon - alpha -2b treatment of malignant melanoma.en_GB
dc.contributor.departmentAdelaide and Meath Hospital, Tallaght, Ireland. waltenudi@yahoo.comen_GB
dc.identifier.journalAfrican journal of psychiatryen_GB
dc.description.provinceLeinster-

Related articles on PubMed

All Items in Lenus, The Irish Health Repository are protected by copyright, with all rights reserved, unless otherwise indicated.