Hdl Handle:
http://hdl.handle.net/10147/207882
Title:
The physiology of growth hormone and sport.
Authors:
Widdowson, W Matthew; Healy, Marie-Louise; Sonksen, Peter H; Gibney, James
Affiliation:
Department of Endocrinology and Diabetes, Adelaide and Meath Hospital, Tallaght, , Dublin 24, Ireland.
Citation:
Growth Horm IGF Res. 2009 Aug;19(4):308-19. Epub 2009 Jun 7.
Journal:
Growth hormone & IGF research : official journal of the Growth Hormone Research, Society and the International IGF Research Society
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207882
DOI:
10.1016/j.ghir.2009.04.023
PubMed ID:
19505835
Abstract:
The growth hormone (GH)/ insulin-like growth factor-I (IGF-I) axis exerts short-and long-term metabolic effects that are potentially important during exercise. Exercise is a potent stimulus to GH release and there is some evidence that the acute increase in GH is important in regulating substrate metabolism post-exercise. Regular exercise also increases 24-hour GH secretion rates, which potentially contributes to the physiologic changes induced by training. The effects of GH replacement in GH-deficient adults provide a useful model with which to study the effects of the more long-term effects of the GH/ IGF-I axis. There is convincing evidence that GH replacement increases exercise capacity. Measures of exercise performance including maximal oxygen uptake (VO2max) and ventilatory threshold (VeT) are impaired in GH deficiency and improved by GH replacement, probably through some combination of increased oxygen delivery to exercising muscle, increased fatty acid availability with glycogen sparing, increased muscle strength, improved body composition and improved thermoregulation. Administration of supraphysiologic doses of GH to athletes increases fatty acid availability and reduces oxidative protein loss particularly during exercise, and increases lean body mass. It is not known whether these effects translate to improved athletic performance, although recombinant human GH is known to be widely abused in sport. The model of acromegaly provides evidence that long-term GH excess does not result in improved performance but it is possible that a "window" exists in which the protein anabolic effects of supraphysiologic GH might be advantageous.
Language:
eng
MeSH:
Acromegaly/therapy; Adipose Tissue; *Athletes; Exercise; Female; Human Growth Hormone/*therapeutic use; Humans; Insulin-Like Growth Factor I/metabolism; Male; Muscles/drug effects; Oxygen/chemistry; Oxygen Consumption/drug effects; Recombinant Proteins/therapeutic use; *Sports; Time Factors
ISSN:
1532-2238 (Electronic); 1096-6374 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorWiddowson, W Matthewen_GB
dc.contributor.authorHealy, Marie-Louiseen_GB
dc.contributor.authorSonksen, Peter Hen_GB
dc.contributor.authorGibney, Jamesen_GB
dc.date.accessioned2012-02-01T10:49:01Z-
dc.date.available2012-02-01T10:49:01Z-
dc.date.issued2012-02-01T10:49:01Z-
dc.identifier.citationGrowth Horm IGF Res. 2009 Aug;19(4):308-19. Epub 2009 Jun 7.en_GB
dc.identifier.issn1532-2238 (Electronic)en_GB
dc.identifier.issn1096-6374 (Linking)en_GB
dc.identifier.pmid19505835en_GB
dc.identifier.doi10.1016/j.ghir.2009.04.023en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207882-
dc.description.abstractThe growth hormone (GH)/ insulin-like growth factor-I (IGF-I) axis exerts short-and long-term metabolic effects that are potentially important during exercise. Exercise is a potent stimulus to GH release and there is some evidence that the acute increase in GH is important in regulating substrate metabolism post-exercise. Regular exercise also increases 24-hour GH secretion rates, which potentially contributes to the physiologic changes induced by training. The effects of GH replacement in GH-deficient adults provide a useful model with which to study the effects of the more long-term effects of the GH/ IGF-I axis. There is convincing evidence that GH replacement increases exercise capacity. Measures of exercise performance including maximal oxygen uptake (VO2max) and ventilatory threshold (VeT) are impaired in GH deficiency and improved by GH replacement, probably through some combination of increased oxygen delivery to exercising muscle, increased fatty acid availability with glycogen sparing, increased muscle strength, improved body composition and improved thermoregulation. Administration of supraphysiologic doses of GH to athletes increases fatty acid availability and reduces oxidative protein loss particularly during exercise, and increases lean body mass. It is not known whether these effects translate to improved athletic performance, although recombinant human GH is known to be widely abused in sport. The model of acromegaly provides evidence that long-term GH excess does not result in improved performance but it is possible that a "window" exists in which the protein anabolic effects of supraphysiologic GH might be advantageous.en_GB
dc.language.isoengen_GB
dc.subject.meshAcromegaly/therapyen_GB
dc.subject.meshAdipose Tissueen_GB
dc.subject.mesh*Athletesen_GB
dc.subject.meshExerciseen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHuman Growth Hormone/*therapeutic useen_GB
dc.subject.meshHumansen_GB
dc.subject.meshInsulin-Like Growth Factor I/metabolismen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMuscles/drug effectsen_GB
dc.subject.meshOxygen/chemistryen_GB
dc.subject.meshOxygen Consumption/drug effectsen_GB
dc.subject.meshRecombinant Proteins/therapeutic useen_GB
dc.subject.mesh*Sportsen_GB
dc.subject.meshTime Factorsen_GB
dc.titleThe physiology of growth hormone and sport.en_GB
dc.contributor.departmentDepartment of Endocrinology and Diabetes, Adelaide and Meath Hospital, Tallaght, , Dublin 24, Ireland.en_GB
dc.identifier.journalGrowth hormone & IGF research : official journal of the Growth Hormone Research, Society and the International IGF Research Societyen_GB
dc.description.provinceLeinster-

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