Primary prevention of colorectal cancer: are we closer to reality?

Hdl Handle:
http://hdl.handle.net/10147/207878
Title:
Primary prevention of colorectal cancer: are we closer to reality?
Authors:
Qasim, Asghar; O'Morain, Colm
Affiliation:
Adelaide and Meath Hospital, Tallaght, Trinity College Dublin, AMNCH-Tallaght,, Dublin 24, Ireland. qasima@tcd.ie
Citation:
Eur J Gastroenterol Hepatol. 2010 Jan;22(1):9-17.
Journal:
European journal of gastroenterology & hepatology
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207878
DOI:
10.1097/MEG.0b013e328330d0d6
PubMed ID:
19773663
Abstract:
Colorectal cancer is one of the leading causes of morbidity and mortality worldwide. An early detection of colorectal cancer determines therapeutic outcomes, while primary prevention remains a challenge. Our aim was to review the dietary, geographical and genetic factors in the causation and their possible role in the primary prevention of colorectal cancer. Data from experimental and clinical studies and population screening programmes were analysed to determine the factors responsible for causation of colorectal cancer. The role of dietary constituents, including the consumption of fat, red meat, fibre content, alcohol consumption, and other lifestyle issues, including obesity, lack of exercise and geographical variations in cancer prevalence were reviewed. The role of genetic and lifestyle factors in causation of colorectal cancer is evident from the experimental, clinical and population-based studies. Dietary factors, including the consumption of fat, fibre, red meat and alcohol, seem to have a significant influence in this regard. The role of micronutrients, vitamins, calcium may be relevant but remain largely unclear. In conclusion, there is ample evidence favouring the role of various dietary and lifestyle factors in the aetiology of colorectal cancer. Modification of these factors is an attractive option, which is likely to help in the primary prevention and reduced disease burden.
Language:
eng
MeSH:
Alcohol Drinking/adverse effects; Colorectal Neoplasms/epidemiology/etiology/*prevention & control; Diet/adverse effects; Dietary Fats/administration & dosage; Dietary Fiber/administration & dosage; Female; Humans; Life Style; Male; Meat/adverse effects; Micronutrients/therapeutic use; Obesity/complications; Primary Prevention
ISSN:
1473-5687 (Electronic); 0954-691X (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorQasim, Asgharen_GB
dc.contributor.authorO'Morain, Colmen_GB
dc.date.accessioned2012-02-01T10:48:56Z-
dc.date.available2012-02-01T10:48:56Z-
dc.date.issued2012-02-01T10:48:56Z-
dc.identifier.citationEur J Gastroenterol Hepatol. 2010 Jan;22(1):9-17.en_GB
dc.identifier.issn1473-5687 (Electronic)en_GB
dc.identifier.issn0954-691X (Linking)en_GB
dc.identifier.pmid19773663en_GB
dc.identifier.doi10.1097/MEG.0b013e328330d0d6en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207878-
dc.description.abstractColorectal cancer is one of the leading causes of morbidity and mortality worldwide. An early detection of colorectal cancer determines therapeutic outcomes, while primary prevention remains a challenge. Our aim was to review the dietary, geographical and genetic factors in the causation and their possible role in the primary prevention of colorectal cancer. Data from experimental and clinical studies and population screening programmes were analysed to determine the factors responsible for causation of colorectal cancer. The role of dietary constituents, including the consumption of fat, red meat, fibre content, alcohol consumption, and other lifestyle issues, including obesity, lack of exercise and geographical variations in cancer prevalence were reviewed. The role of genetic and lifestyle factors in causation of colorectal cancer is evident from the experimental, clinical and population-based studies. Dietary factors, including the consumption of fat, fibre, red meat and alcohol, seem to have a significant influence in this regard. The role of micronutrients, vitamins, calcium may be relevant but remain largely unclear. In conclusion, there is ample evidence favouring the role of various dietary and lifestyle factors in the aetiology of colorectal cancer. Modification of these factors is an attractive option, which is likely to help in the primary prevention and reduced disease burden.en_GB
dc.language.isoengen_GB
dc.subject.meshAlcohol Drinking/adverse effectsen_GB
dc.subject.meshColorectal Neoplasms/epidemiology/etiology/*prevention & controlen_GB
dc.subject.meshDiet/adverse effectsen_GB
dc.subject.meshDietary Fats/administration & dosageen_GB
dc.subject.meshDietary Fiber/administration & dosageen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshLife Styleen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMeat/adverse effectsen_GB
dc.subject.meshMicronutrients/therapeutic useen_GB
dc.subject.meshObesity/complicationsen_GB
dc.subject.meshPrimary Preventionen_GB
dc.titlePrimary prevention of colorectal cancer: are we closer to reality?en_GB
dc.contributor.departmentAdelaide and Meath Hospital, Tallaght, Trinity College Dublin, AMNCH-Tallaght,, Dublin 24, Ireland. qasima@tcd.ieen_GB
dc.identifier.journalEuropean journal of gastroenterology & hepatologyen_GB
dc.description.provinceLeinster-

Related articles on PubMed

All Items in Lenus, The Irish Health Repository are protected by copyright, with all rights reserved, unless otherwise indicated.