Establishing a family risk assessment clinic for breast cancer.

Hdl Handle:
http://hdl.handle.net/10147/207857
Title:
Establishing a family risk assessment clinic for breast cancer.
Authors:
Mulsow, Jurgen; Lee, James; Dempsey, Cathriona; Rothwell, Jane; Geraghty, James G
Affiliation:
Tallaght Breast Unit, Adelaide and Meath Hospital Tallaght, Dublin, Ireland.
Citation:
Breast J. 2009 Sep-Oct;15 Suppl 1:S33-8.
Journal:
The breast journal
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207857
DOI:
10.1111/j.1524-4741.2009.00825.x
PubMed ID:
19775328
Abstract:
Breast cancer is the most common cancer affecting European women and the leading cause of cancer-related death. A total of 15-20% of women who develop breast cancer have a family history and 5-10% a true genetic predisposition. The identification and screening of women at increased risk may allow early detection of breast cancer and improve prognosis. We established a family risk assessment clinic in May 2005 to assess and counsel women with a family history of breast cancer, to initiate surveillance, and to offer risk-reducing strategies for selected high-risk patients. Patients at medium or high risk of developing breast cancer according to NICE guidelines were accepted. Family history was determined by structured questionnaire and interview. Lifetime risk of developing breast cancer was calculated using Claus and Tyrer-Cuzick scoring. Risk of carrying a breast cancer-related gene mutation was calculated using the Manchester system. One thousand two hundred and forty-three patients have been referred. Ninety-two percent were at medium or high risk of developing breast cancer. Formal assessment of risk has been performed in 368 patients, 73% have a high lifetime risk of developing breast cancer, and 72% a Manchester score >or=16. BRCA1/2 mutations have been identified in 14 patients and breast cancer diagnosed in two. Our initial experience of family risk assessment has shown there to be a significant demand for this service. Identification of patients at increased risk of developing breast cancer allows us to provide individuals with accurate risk profiles, and enables patients to make informed choices regarding their follow-up and management.
Language:
eng
MeSH:
Adolescent; Adult; Breast Neoplasms/*genetics; Female; Genes, BRCA1; Genes, BRCA2; Genetic Testing; Humans; Middle Aged; Mutation; *Risk Assessment
ISSN:
1524-4741 (Electronic); 1075-122X (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorMulsow, Jurgenen_GB
dc.contributor.authorLee, Jamesen_GB
dc.contributor.authorDempsey, Cathrionaen_GB
dc.contributor.authorRothwell, Janeen_GB
dc.contributor.authorGeraghty, James Gen_GB
dc.date.accessioned2012-02-01T10:48:14Z-
dc.date.available2012-02-01T10:48:14Z-
dc.date.issued2012-02-01T10:48:14Z-
dc.identifier.citationBreast J. 2009 Sep-Oct;15 Suppl 1:S33-8.en_GB
dc.identifier.issn1524-4741 (Electronic)en_GB
dc.identifier.issn1075-122X (Linking)en_GB
dc.identifier.pmid19775328en_GB
dc.identifier.doi10.1111/j.1524-4741.2009.00825.xen_GB
dc.identifier.urihttp://hdl.handle.net/10147/207857-
dc.description.abstractBreast cancer is the most common cancer affecting European women and the leading cause of cancer-related death. A total of 15-20% of women who develop breast cancer have a family history and 5-10% a true genetic predisposition. The identification and screening of women at increased risk may allow early detection of breast cancer and improve prognosis. We established a family risk assessment clinic in May 2005 to assess and counsel women with a family history of breast cancer, to initiate surveillance, and to offer risk-reducing strategies for selected high-risk patients. Patients at medium or high risk of developing breast cancer according to NICE guidelines were accepted. Family history was determined by structured questionnaire and interview. Lifetime risk of developing breast cancer was calculated using Claus and Tyrer-Cuzick scoring. Risk of carrying a breast cancer-related gene mutation was calculated using the Manchester system. One thousand two hundred and forty-three patients have been referred. Ninety-two percent were at medium or high risk of developing breast cancer. Formal assessment of risk has been performed in 368 patients, 73% have a high lifetime risk of developing breast cancer, and 72% a Manchester score >or=16. BRCA1/2 mutations have been identified in 14 patients and breast cancer diagnosed in two. Our initial experience of family risk assessment has shown there to be a significant demand for this service. Identification of patients at increased risk of developing breast cancer allows us to provide individuals with accurate risk profiles, and enables patients to make informed choices regarding their follow-up and management.en_GB
dc.language.isoengen_GB
dc.subject.meshAdolescenten_GB
dc.subject.meshAdulten_GB
dc.subject.meshBreast Neoplasms/*geneticsen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshGenes, BRCA1en_GB
dc.subject.meshGenes, BRCA2en_GB
dc.subject.meshGenetic Testingen_GB
dc.subject.meshHumansen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshMutationen_GB
dc.subject.mesh*Risk Assessmenten_GB
dc.titleEstablishing a family risk assessment clinic for breast cancer.en_GB
dc.contributor.departmentTallaght Breast Unit, Adelaide and Meath Hospital Tallaght, Dublin, Ireland.en_GB
dc.identifier.journalThe breast journalen_GB
dc.description.provinceLeinster-

Related articles on PubMed

All Items in Lenus, The Irish Health Repository are protected by copyright, with all rights reserved, unless otherwise indicated.