Evidence for a specific defect in hippocampal memory in overt and subclinical hypothyroidism.

Hdl Handle:
http://hdl.handle.net/10147/207849
Title:
Evidence for a specific defect in hippocampal memory in overt and subclinical hypothyroidism.
Authors:
Correia, Neuman; Mullally, Sinead; Cooke, Gillian; Tun, Tommy Kyaw; Phelan, Niamh; Feeney, Joanne; Fitzgibbon, Maria; Boran, Gerard; O'Mara, Shane; Gibney, James
Affiliation:
Department of Endocrinology and Diabetes, Adelaide and Meath Hospital,, incorporating the National Children's Hospital, Tallaght, Dublin 24, Ireland.
Citation:
J Clin Endocrinol Metab. 2009 Oct;94(10):3789-97. Epub 2009 Jul 7.
Journal:
The Journal of clinical endocrinology and metabolism
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207849
DOI:
10.1210/jc.2008-2702
PubMed ID:
19584178
Abstract:
CONTEXT: Declarative memory largely depends upon normal functioning temporal lobes (hippocampal complex) and prefrontal cortex. Animal studies suggest abnormal hippocampal function in hypothyroidism. OBJECTIVE: The aim of the study was to assess declarative memory in overt and subclinical (SCH) hypothyroid patients before and after l-T(4) (LT4) replacement and in matched normal subjects. DESIGN AND SETTING: A prospective, open-labeled interventional study was conducted at a teaching hospital. PARTICIPANTS AND INTERVENTION: Hypothyroid (n = 21) and SCH (n = 17) patients underwent neuropsychological tests at baseline and 3 and 6 months after LT4 replacement. Normal subjects were studied at the same time-points. MAIN OUTCOME: Tests of spatial, verbal, associative, and working memory; attention; and response inhibition and the Hospital Anxiety and Depression Scale were administered. RESULTS: Baseline deficits in spatial, associative, and verbal memory, which rely upon the integrity of the hippocampal and frontal areas, were identified in patients with overt hypothyroidism. Spatial and verbal memory were impaired in SCH patients (P < 0.05). TSH levels correlated negatively (P < 0.05) with these deficits. After LT4 replacement, verbal memory normalized. Spatial memory normalized in the SCH group but remained impaired in the hypothyroid group. Associative memory deficits persisted in the overt hypothyroid group. Hospital Anxiety and Depression Scale scores did not correlate with cognitive function. Measures of attention and response inhibition did not differ from control subjects. CONCLUSION: Cognitive impairment occurs in SCH and more markedly in overt hypothyroidism. These impairments appear predominantly mnemonic in nature, suggesting that the etiology is not indicative of general cognitive slowing. We propose that these deficits may reflect an underlying disruption of normal hippocampal function and/or connectivity.
Language:
eng
MeSH:
Adult; Aged; Attention; Case-Control Studies; Female; Hippocampus/*physiopathology; Hospitals, Teaching; Humans; Hypothyroidism/*complications/drug therapy/*physiopathology/psychology; Male; *Memory; Memory Disorders/*etiology/*physiopathology/psychology; Memory, Short-Term; Mental Recall; Middle Aged; Neuropsychological Tests; Thyroxine/*therapeutic use
ISSN:
1945-7197 (Electronic); 0021-972X (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorCorreia, Neumanen_GB
dc.contributor.authorMullally, Sineaden_GB
dc.contributor.authorCooke, Gillianen_GB
dc.contributor.authorTun, Tommy Kyawen_GB
dc.contributor.authorPhelan, Niamhen_GB
dc.contributor.authorFeeney, Joanneen_GB
dc.contributor.authorFitzgibbon, Mariaen_GB
dc.contributor.authorBoran, Gerarden_GB
dc.contributor.authorO'Mara, Shaneen_GB
dc.contributor.authorGibney, Jamesen_GB
dc.date.accessioned2012-02-01T10:47:58Z-
dc.date.available2012-02-01T10:47:58Z-
dc.date.issued2012-02-01T10:47:58Z-
dc.identifier.citationJ Clin Endocrinol Metab. 2009 Oct;94(10):3789-97. Epub 2009 Jul 7.en_GB
dc.identifier.issn1945-7197 (Electronic)en_GB
dc.identifier.issn0021-972X (Linking)en_GB
dc.identifier.pmid19584178en_GB
dc.identifier.doi10.1210/jc.2008-2702en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207849-
dc.description.abstractCONTEXT: Declarative memory largely depends upon normal functioning temporal lobes (hippocampal complex) and prefrontal cortex. Animal studies suggest abnormal hippocampal function in hypothyroidism. OBJECTIVE: The aim of the study was to assess declarative memory in overt and subclinical (SCH) hypothyroid patients before and after l-T(4) (LT4) replacement and in matched normal subjects. DESIGN AND SETTING: A prospective, open-labeled interventional study was conducted at a teaching hospital. PARTICIPANTS AND INTERVENTION: Hypothyroid (n = 21) and SCH (n = 17) patients underwent neuropsychological tests at baseline and 3 and 6 months after LT4 replacement. Normal subjects were studied at the same time-points. MAIN OUTCOME: Tests of spatial, verbal, associative, and working memory; attention; and response inhibition and the Hospital Anxiety and Depression Scale were administered. RESULTS: Baseline deficits in spatial, associative, and verbal memory, which rely upon the integrity of the hippocampal and frontal areas, were identified in patients with overt hypothyroidism. Spatial and verbal memory were impaired in SCH patients (P < 0.05). TSH levels correlated negatively (P < 0.05) with these deficits. After LT4 replacement, verbal memory normalized. Spatial memory normalized in the SCH group but remained impaired in the hypothyroid group. Associative memory deficits persisted in the overt hypothyroid group. Hospital Anxiety and Depression Scale scores did not correlate with cognitive function. Measures of attention and response inhibition did not differ from control subjects. CONCLUSION: Cognitive impairment occurs in SCH and more markedly in overt hypothyroidism. These impairments appear predominantly mnemonic in nature, suggesting that the etiology is not indicative of general cognitive slowing. We propose that these deficits may reflect an underlying disruption of normal hippocampal function and/or connectivity.en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAgeden_GB
dc.subject.meshAttentionen_GB
dc.subject.meshCase-Control Studiesen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHippocampus/*physiopathologyen_GB
dc.subject.meshHospitals, Teachingen_GB
dc.subject.meshHumansen_GB
dc.subject.meshHypothyroidism/*complications/drug therapy/*physiopathology/psychologyen_GB
dc.subject.meshMaleen_GB
dc.subject.mesh*Memoryen_GB
dc.subject.meshMemory Disorders/*etiology/*physiopathology/psychologyen_GB
dc.subject.meshMemory, Short-Termen_GB
dc.subject.meshMental Recallen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshNeuropsychological Testsen_GB
dc.subject.meshThyroxine/*therapeutic useen_GB
dc.titleEvidence for a specific defect in hippocampal memory in overt and subclinical hypothyroidism.en_GB
dc.contributor.departmentDepartment of Endocrinology and Diabetes, Adelaide and Meath Hospital,, incorporating the National Children's Hospital, Tallaght, Dublin 24, Ireland.en_GB
dc.identifier.journalThe Journal of clinical endocrinology and metabolismen_GB
dc.description.provinceLeinster-

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