Lack of differential pattern in central adiposity and metabolic syndrome in Barrett's esophagus and gastroesophageal reflux disease.

Hdl Handle:
http://hdl.handle.net/10147/207826
Title:
Lack of differential pattern in central adiposity and metabolic syndrome in Barrett's esophagus and gastroesophageal reflux disease.
Authors:
Healy, L A; Ryan, A M; Pidgeon, G; Ravi, N; Reynolds, J V
Affiliation:
Department of Clinical Surgery, St. James' Hospital and Trinity College, Dublin, , Ireland.
Citation:
Dis Esophagus. 2010 Jul;23(5):386-91. Epub 2010 Mar 26.
Journal:
Diseases of the esophagus : official journal of the International Society for, Diseases of the Esophagus / I.S.D.E
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207826
DOI:
10.1111/j.1442-2050.2010.01052.x
PubMed ID:
20353443
Abstract:
Obesity is an established risk factor for esophageal adenocarcinoma, although the mechanism is unclear. A pathway from reflux to inflammation through metaplasia is the dominant hypothesis, and an added role relating to visceral adiposity and the metabolic syndrome has been mooted in Barrett's esophagus (BE) patients. Whether BE differs from gastroesophageal reflux disease (GERD) in obesity and metabolic syndrome profiles is unclear, and this was the focus of this study. Patients with proven BE or GERD were randomly selected from the unit data registry and invited to attend for metabolic syndrome screening, anthropometry studies including segmental body composition analysis, and laboratory tests including fasting lipids, insulin, and C-reactive protein. Metabolic syndrome was defined using the National Cholesterol Education Program (NCEP) and the International Diabetes Federation (IDF) criteria. One hundred and eighteen BE patients and 113 age- and sex-matched GERD controls were studied. The incidence of obesity (body mass index >30 kg/m(2)) was 36% and 38%, respectively, with the pattern of fat deposition predominantly central and an estimated trunk fat mass of 13 and 14 kg, respectively. Using the NCEP criteria, metabolic syndrome was significantly more common in the BE cohort (30% vs 20%, P < 0.05), but there was no significant difference using IDF criteria (42% vs 37%, P= 0.340). Central obesity and the metabolic syndrome are common in both Barrett's and GERD cohorts, but not significantly different, suggesting that central obesity and the metabolic syndrome does not per se impact on the development of BE in a reflux population. In BE, the importance of obesity and the metabolic syndrome in disease progression merits further study.
Language:
eng
MeSH:
Adenocarcinoma/etiology; Barrett Esophagus/*complications/pathology; Esophageal Neoplasms/etiology; Female; Gastroesophageal Reflux/*complications/pathology; Humans; Male; Metabolic Syndrome X/*complications/pathology; Metaplasia/etiology; Middle Aged; Obesity, Abdominal/*complications/metabolism/pathology
ISSN:
1442-2050 (Electronic); 1120-8694 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorHealy, L Aen_GB
dc.contributor.authorRyan, A Men_GB
dc.contributor.authorPidgeon, Gen_GB
dc.contributor.authorRavi, Nen_GB
dc.contributor.authorReynolds, J Ven_GB
dc.date.accessioned2012-02-01T10:45:48Z-
dc.date.available2012-02-01T10:45:48Z-
dc.date.issued2012-02-01T10:45:48Z-
dc.identifier.citationDis Esophagus. 2010 Jul;23(5):386-91. Epub 2010 Mar 26.en_GB
dc.identifier.issn1442-2050 (Electronic)en_GB
dc.identifier.issn1120-8694 (Linking)en_GB
dc.identifier.pmid20353443en_GB
dc.identifier.doi10.1111/j.1442-2050.2010.01052.xen_GB
dc.identifier.urihttp://hdl.handle.net/10147/207826-
dc.description.abstractObesity is an established risk factor for esophageal adenocarcinoma, although the mechanism is unclear. A pathway from reflux to inflammation through metaplasia is the dominant hypothesis, and an added role relating to visceral adiposity and the metabolic syndrome has been mooted in Barrett's esophagus (BE) patients. Whether BE differs from gastroesophageal reflux disease (GERD) in obesity and metabolic syndrome profiles is unclear, and this was the focus of this study. Patients with proven BE or GERD were randomly selected from the unit data registry and invited to attend for metabolic syndrome screening, anthropometry studies including segmental body composition analysis, and laboratory tests including fasting lipids, insulin, and C-reactive protein. Metabolic syndrome was defined using the National Cholesterol Education Program (NCEP) and the International Diabetes Federation (IDF) criteria. One hundred and eighteen BE patients and 113 age- and sex-matched GERD controls were studied. The incidence of obesity (body mass index >30 kg/m(2)) was 36% and 38%, respectively, with the pattern of fat deposition predominantly central and an estimated trunk fat mass of 13 and 14 kg, respectively. Using the NCEP criteria, metabolic syndrome was significantly more common in the BE cohort (30% vs 20%, P < 0.05), but there was no significant difference using IDF criteria (42% vs 37%, P= 0.340). Central obesity and the metabolic syndrome are common in both Barrett's and GERD cohorts, but not significantly different, suggesting that central obesity and the metabolic syndrome does not per se impact on the development of BE in a reflux population. In BE, the importance of obesity and the metabolic syndrome in disease progression merits further study.en_GB
dc.language.isoengen_GB
dc.subject.meshAdenocarcinoma/etiologyen_GB
dc.subject.meshBarrett Esophagus/*complications/pathologyen_GB
dc.subject.meshEsophageal Neoplasms/etiologyen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshGastroesophageal Reflux/*complications/pathologyen_GB
dc.subject.meshHumansen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMetabolic Syndrome X/*complications/pathologyen_GB
dc.subject.meshMetaplasia/etiologyen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshObesity, Abdominal/*complications/metabolism/pathologyen_GB
dc.titleLack of differential pattern in central adiposity and metabolic syndrome in Barrett's esophagus and gastroesophageal reflux disease.en_GB
dc.contributor.departmentDepartment of Clinical Surgery, St. James' Hospital and Trinity College, Dublin, , Ireland.en_GB
dc.identifier.journalDiseases of the esophagus : official journal of the International Society for, Diseases of the Esophagus / I.S.D.Een_GB
dc.description.provinceLeinster-

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