Meta-analysis of timolol on diurnal and nighttime intraocular pressure and blood pressure.

Hdl Handle:
http://hdl.handle.net/10147/207758
Title:
Meta-analysis of timolol on diurnal and nighttime intraocular pressure and blood pressure.
Authors:
Lee, Princeton Wen-Yuan; Doyle, Aoife; Stewart, Jeanette A; Kristoffersen, Caroline J; Stewart, William C
Affiliation:
Royal Victoria Eye and Ear Hospital, Dublin, Ireland.
Citation:
Eur J Ophthalmol. 2010 Nov-Dec;20(6):1035-41.
Journal:
European journal of ophthalmology
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207758
PubMed ID:
20491052
Abstract:
PURPOSE: To evaluate the nighttime intraocular pressure (IOP) and blood pressure (BP) response to timolol treatment in patients with ocular hypertension or primary open-angle glaucoma. METHODS: This was a meta-analysis of previously published studies that must have been randomized, prospective, crossover or parallel, single or double-masked trials. The treatment period must have been >/=2 weeks with >/=19 patients per treatment arm for a crossover, and >/=50 patients for a parallel designed trial. Studies must have included both baseline and treated 24-hour curves. RESULTS: For the IOP analysis, we included 8 articles with 340 patients. A reduction from baseline was observed for timolol at each time point and for the 24-hour curve (p</=0.009). When 2 studies, in which timolol was used adjunctively, were removed, a similar difference was observed as above at each time point and for the 24-hour curve (p</=0.003). In 2 studies, there were small reductions from baseline for the mean diastolic and systolic BPs at most time points and for the 24-hour curve (3.9 and 4.2 mmHg, respectively) with timolol treatment. The ocular perfusion pressure did not show any difference between baseline and timolol treatment at any time point or for the 24-hour curve (p>0.05). CONCLUSIONS: This meta-analysis suggests that topical timolol therapy provides an ocular hypotensive effect over the 24-hour curve, including the nighttime hours, and while small reductions in the systolic and diastolic pressures occur, the ocular perfusion pressure is not altered over 24 hours.
Language:
eng
MeSH:
Administration, Topical; Adrenergic beta-Antagonists/*administration & dosage; Blood Pressure/*drug effects/physiology; Circadian Rhythm/*drug effects/physiology; Glaucoma, Open-Angle/*drug therapy/physiopathology; Humans; Intraocular Pressure/*drug effects/physiology; Ocular Hypertension/drug therapy/physiopathology; Ophthalmic Solutions/administration & dosage; Randomized Controlled Trials as Topic; Timolol/*administration & dosage; Tonometry, Ocular
ISSN:
1724-6016 (Electronic); 1120-6721 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorLee, Princeton Wen-Yuanen_GB
dc.contributor.authorDoyle, Aoifeen_GB
dc.contributor.authorStewart, Jeanette Aen_GB
dc.contributor.authorKristoffersen, Caroline Jen_GB
dc.contributor.authorStewart, William Cen_GB
dc.date.accessioned2012-02-01T10:40:21Z-
dc.date.available2012-02-01T10:40:21Z-
dc.date.issued2012-02-01T10:40:21Z-
dc.identifier.citationEur J Ophthalmol. 2010 Nov-Dec;20(6):1035-41.en_GB
dc.identifier.issn1724-6016 (Electronic)en_GB
dc.identifier.issn1120-6721 (Linking)en_GB
dc.identifier.pmid20491052en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207758-
dc.description.abstractPURPOSE: To evaluate the nighttime intraocular pressure (IOP) and blood pressure (BP) response to timolol treatment in patients with ocular hypertension or primary open-angle glaucoma. METHODS: This was a meta-analysis of previously published studies that must have been randomized, prospective, crossover or parallel, single or double-masked trials. The treatment period must have been >/=2 weeks with >/=19 patients per treatment arm for a crossover, and >/=50 patients for a parallel designed trial. Studies must have included both baseline and treated 24-hour curves. RESULTS: For the IOP analysis, we included 8 articles with 340 patients. A reduction from baseline was observed for timolol at each time point and for the 24-hour curve (p</=0.009). When 2 studies, in which timolol was used adjunctively, were removed, a similar difference was observed as above at each time point and for the 24-hour curve (p</=0.003). In 2 studies, there were small reductions from baseline for the mean diastolic and systolic BPs at most time points and for the 24-hour curve (3.9 and 4.2 mmHg, respectively) with timolol treatment. The ocular perfusion pressure did not show any difference between baseline and timolol treatment at any time point or for the 24-hour curve (p>0.05). CONCLUSIONS: This meta-analysis suggests that topical timolol therapy provides an ocular hypotensive effect over the 24-hour curve, including the nighttime hours, and while small reductions in the systolic and diastolic pressures occur, the ocular perfusion pressure is not altered over 24 hours.en_GB
dc.language.isoengen_GB
dc.subject.meshAdministration, Topicalen_GB
dc.subject.meshAdrenergic beta-Antagonists/*administration & dosageen_GB
dc.subject.meshBlood Pressure/*drug effects/physiologyen_GB
dc.subject.meshCircadian Rhythm/*drug effects/physiologyen_GB
dc.subject.meshGlaucoma, Open-Angle/*drug therapy/physiopathologyen_GB
dc.subject.meshHumansen_GB
dc.subject.meshIntraocular Pressure/*drug effects/physiologyen_GB
dc.subject.meshOcular Hypertension/drug therapy/physiopathologyen_GB
dc.subject.meshOphthalmic Solutions/administration & dosageen_GB
dc.subject.meshRandomized Controlled Trials as Topicen_GB
dc.subject.meshTimolol/*administration & dosageen_GB
dc.subject.meshTonometry, Ocularen_GB
dc.titleMeta-analysis of timolol on diurnal and nighttime intraocular pressure and blood pressure.en_GB
dc.contributor.departmentRoyal Victoria Eye and Ear Hospital, Dublin, Ireland.en_GB
dc.identifier.journalEuropean journal of ophthalmologyen_GB
dc.description.provinceLeinster-
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