The prevalence of vitamin D deficiency in consecutive new patients seen over a 6-month period in general rheumatology clinics.

Hdl Handle:
http://hdl.handle.net/10147/207739
Title:
The prevalence of vitamin D deficiency in consecutive new patients seen over a 6-month period in general rheumatology clinics.
Authors:
Haroon, Muhammad; Bond, Ursula; Quillinan, Niamh; Phelan, Mark J; Regan, Michael J
Affiliation:
Arthritis and Osteoporosis Centre, Department of Rheumatology, South, Infirmary-Victoria University Hospital, Cork, Ireland. mharoon301@hotmail.com
Citation:
Clin Rheumatol. 2011 Jun;30(6):789-94. Epub 2010 Dec 24.
Journal:
Clinical rheumatology
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207739
DOI:
10.1007/s10067-010-1659-0
PubMed ID:
21184246
Abstract:
The objectives of this study are to assess: (a) the prevalence of vitamin D deficiency among new patients attending rheumatology outpatient departments, (b) the age profile of these low vitamin D patients and (c) whether any diagnostic category had a particularly high number of vitamin D-deficient patients. All new patients seen consecutively in general rheumatology clinics between January to June 2007 inclusive were eligible to partake in this study, and 231 out of 264 consented to do so. Parathyroid hormone, 25-hydroxyvitamin D, creatinine, calcium, phosphate, albumin and alkaline phosphatase levels were measured. We defined vitamin D deficiency as </=53 nmol/l and severe deficiency as </=25 nmol/l. Overall, 70% of 231 patients had vitamin D deficiency, and 26% had severe deficiency. Sixty-five percent of patients aged >/=65 and 78% of patients aged </=30 years had low vitamin D levels. Vitamin D deficiency in each diagnostic category was as follows: (a) inflammatory joint diseases/connective tissue diseases (IJD/CTD), 69%; (b) soft tissue rheumatism, 77%; (c) osteoarthritis, 62%; (d) non-specific musculoskeletal back pain, 75% and (e) osteoporosis, 71%. Seasonal variation of vitamin D levels was noted in all diagnostic groups apart from IJD/CTD group, where the degree of vitamin D deficiency persisted from late winter to peak summer. Very high prevalence of vitamin D deficiency was noted in all diagnostic categories (p = 0.006), and it was independent of age (p = 0.297). The results suggest vitamin D deficiency as a possible modifiable risk factor in different rheumatologic conditions, and its role in IJD/CTD warrants further attention.
Language:
eng
MeSH:
Adult; Age Factors; Aged; Aged, 80 and over; *Ambulatory Care Facilities; Back Pain/epidemiology/physiopathology; Connective Tissue Diseases/*epidemiology/physiopathology; Female; Humans; Longitudinal Studies; Male; Middle Aged; Osteoarthritis/epidemiology/physiopathology; Osteoporosis/epidemiology/physiopathology; Prevalence; Retrospective Studies; Rheumatic Diseases/*epidemiology/physiopathology; Risk Factors; Vitamin D Deficiency/*epidemiology/physiopathology
ISSN:
1434-9949 (Electronic); 0770-3198 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorHaroon, Muhammaden_GB
dc.contributor.authorBond, Ursulaen_GB
dc.contributor.authorQuillinan, Niamhen_GB
dc.contributor.authorPhelan, Mark Jen_GB
dc.contributor.authorRegan, Michael Jen_GB
dc.date.accessioned2012-02-01T10:42:33Z-
dc.date.available2012-02-01T10:42:33Z-
dc.date.issued2012-02-01T10:42:33Z-
dc.identifier.citationClin Rheumatol. 2011 Jun;30(6):789-94. Epub 2010 Dec 24.en_GB
dc.identifier.issn1434-9949 (Electronic)en_GB
dc.identifier.issn0770-3198 (Linking)en_GB
dc.identifier.pmid21184246en_GB
dc.identifier.doi10.1007/s10067-010-1659-0en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207739-
dc.description.abstractThe objectives of this study are to assess: (a) the prevalence of vitamin D deficiency among new patients attending rheumatology outpatient departments, (b) the age profile of these low vitamin D patients and (c) whether any diagnostic category had a particularly high number of vitamin D-deficient patients. All new patients seen consecutively in general rheumatology clinics between January to June 2007 inclusive were eligible to partake in this study, and 231 out of 264 consented to do so. Parathyroid hormone, 25-hydroxyvitamin D, creatinine, calcium, phosphate, albumin and alkaline phosphatase levels were measured. We defined vitamin D deficiency as </=53 nmol/l and severe deficiency as </=25 nmol/l. Overall, 70% of 231 patients had vitamin D deficiency, and 26% had severe deficiency. Sixty-five percent of patients aged >/=65 and 78% of patients aged </=30 years had low vitamin D levels. Vitamin D deficiency in each diagnostic category was as follows: (a) inflammatory joint diseases/connective tissue diseases (IJD/CTD), 69%; (b) soft tissue rheumatism, 77%; (c) osteoarthritis, 62%; (d) non-specific musculoskeletal back pain, 75% and (e) osteoporosis, 71%. Seasonal variation of vitamin D levels was noted in all diagnostic groups apart from IJD/CTD group, where the degree of vitamin D deficiency persisted from late winter to peak summer. Very high prevalence of vitamin D deficiency was noted in all diagnostic categories (p = 0.006), and it was independent of age (p = 0.297). The results suggest vitamin D deficiency as a possible modifiable risk factor in different rheumatologic conditions, and its role in IJD/CTD warrants further attention.en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAge Factorsen_GB
dc.subject.meshAgeden_GB
dc.subject.meshAged, 80 and overen_GB
dc.subject.mesh*Ambulatory Care Facilitiesen_GB
dc.subject.meshBack Pain/epidemiology/physiopathologyen_GB
dc.subject.meshConnective Tissue Diseases/*epidemiology/physiopathologyen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshLongitudinal Studiesen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshOsteoarthritis/epidemiology/physiopathologyen_GB
dc.subject.meshOsteoporosis/epidemiology/physiopathologyen_GB
dc.subject.meshPrevalenceen_GB
dc.subject.meshRetrospective Studiesen_GB
dc.subject.meshRheumatic Diseases/*epidemiology/physiopathologyen_GB
dc.subject.meshRisk Factorsen_GB
dc.subject.meshVitamin D Deficiency/*epidemiology/physiopathologyen_GB
dc.titleThe prevalence of vitamin D deficiency in consecutive new patients seen over a 6-month period in general rheumatology clinics.en_GB
dc.contributor.departmentArthritis and Osteoporosis Centre, Department of Rheumatology, South, Infirmary-Victoria University Hospital, Cork, Ireland. mharoon301@hotmail.comen_GB
dc.identifier.journalClinical rheumatologyen_GB
dc.description.provinceMunster-

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