The relationship between maternal insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and IGFBP-3 to gestational age and preterm delivery.

Hdl Handle:
http://hdl.handle.net/10147/207726
Title:
The relationship between maternal insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and IGFBP-3 to gestational age and preterm delivery.
Authors:
Cooley, Sharon M; Donnelly, Jennifer C; Collins, Claire; Geary, Michael P; Rodeck, Charles H; Hindmarsh, Peter C
Affiliation:
Rotunda Hospital, Parnell Street, Dublin 1, Ireland. smcooley@hotmail.com
Citation:
J Perinat Med. 2010 May;38(3):255-9.
Journal:
Journal of perinatal medicine
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207726
DOI:
10.1515/JPM.2010.019
PubMed ID:
20121533
Abstract:
AIMS: To investigate the relationship between levels of insulin-like growth factors 1 and 2 (IGF-1, IGF-2), and insulin-like growth factor binding protein 3 (IGFBP-3) in antenatal maternal serum and gestational age at delivery. METHODS: Prospective cohort study of 1650 low-risk Caucasian women in a London University teaching hospital. Maternal IGF-1, IGF-2 and IGFBP-3 were measured in maternal blood at booking and analyzed with respect to gestational age at delivery. RESULTS: There was no significant association between maternal IGF-1 or IGF-2 and preterm birth (PTB). A significant reduction in mean IGFBP-3 levels was noted with delivery <32 completed weeks (P=0.02). CONCLUSION: Maternal mean IGFBP-3 levels are significantly reduced in cases complicated by delivery <32 completed weeks.
Language:
eng
MeSH:
Adult; Alcohol Drinking; Cohort Studies; Female; *Gestational Age; Humans; Insulin-Like Growth Factor Binding Protein 3/*blood; Insulin-Like Growth Factor I/*analysis; Insulin-Like Growth Factor II/*analysis; Pregnancy; Premature Birth/*blood; Prospective Studies; Smoking
ISSN:
1619-3997 (Electronic); 0300-5577 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorCooley, Sharon Men_GB
dc.contributor.authorDonnelly, Jennifer Cen_GB
dc.contributor.authorCollins, Claireen_GB
dc.contributor.authorGeary, Michael Pen_GB
dc.contributor.authorRodeck, Charles Hen_GB
dc.contributor.authorHindmarsh, Peter Cen_GB
dc.date.accessioned2012-02-01T10:38:08Z-
dc.date.available2012-02-01T10:38:08Z-
dc.date.issued2012-02-01T10:38:08Z-
dc.identifier.citationJ Perinat Med. 2010 May;38(3):255-9.en_GB
dc.identifier.issn1619-3997 (Electronic)en_GB
dc.identifier.issn0300-5577 (Linking)en_GB
dc.identifier.pmid20121533en_GB
dc.identifier.doi10.1515/JPM.2010.019en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207726-
dc.description.abstractAIMS: To investigate the relationship between levels of insulin-like growth factors 1 and 2 (IGF-1, IGF-2), and insulin-like growth factor binding protein 3 (IGFBP-3) in antenatal maternal serum and gestational age at delivery. METHODS: Prospective cohort study of 1650 low-risk Caucasian women in a London University teaching hospital. Maternal IGF-1, IGF-2 and IGFBP-3 were measured in maternal blood at booking and analyzed with respect to gestational age at delivery. RESULTS: There was no significant association between maternal IGF-1 or IGF-2 and preterm birth (PTB). A significant reduction in mean IGFBP-3 levels was noted with delivery <32 completed weeks (P=0.02). CONCLUSION: Maternal mean IGFBP-3 levels are significantly reduced in cases complicated by delivery <32 completed weeks.en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAlcohol Drinkingen_GB
dc.subject.meshCohort Studiesen_GB
dc.subject.meshFemaleen_GB
dc.subject.mesh*Gestational Ageen_GB
dc.subject.meshHumansen_GB
dc.subject.meshInsulin-Like Growth Factor Binding Protein 3/*blooden_GB
dc.subject.meshInsulin-Like Growth Factor I/*analysisen_GB
dc.subject.meshInsulin-Like Growth Factor II/*analysisen_GB
dc.subject.meshPregnancyen_GB
dc.subject.meshPremature Birth/*blooden_GB
dc.subject.meshProspective Studiesen_GB
dc.subject.meshSmokingen_GB
dc.titleThe relationship between maternal insulin-like growth factors 1 and 2 (IGF-1, IGF-2) and IGFBP-3 to gestational age and preterm delivery.en_GB
dc.contributor.departmentRotunda Hospital, Parnell Street, Dublin 1, Ireland. smcooley@hotmail.comen_GB
dc.identifier.journalJournal of perinatal medicineen_GB
dc.description.provinceLeinster-
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