All azoospermic males should be screened for cystic fibrosis mutations before intracytoplasmic sperm injection.

Hdl Handle:
http://hdl.handle.net/10147/207723
Title:
All azoospermic males should be screened for cystic fibrosis mutations before intracytoplasmic sperm injection.
Authors:
Mocanu, Edgar; Shattock, Richard; Barton, David; Rogers, Melissa; Conroy, Ronan; Sheils, Orla; Collins, Claire; Martin, Cara; Harrison, Robert; O'Leary, John
Affiliation:
Human Assisted Reproduction Ireland, Rotunda Hospital, and Royal College of, Surgeons in Ireland, Dublin, Ireland. emocanu@rcsi.ie
Citation:
Fertil Steril. 2010 Nov;94(6):2448-50. Epub 2010 Apr 9.
Journal:
Fertility and sterility
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207723
DOI:
10.1016/j.fertnstert.2010.02.029
PubMed ID:
20381036
Abstract:
We assessed the frequency of CFTR mutations in groups with varying degrees of sub-fertility and compared these groups to a fertile male group with proven paternity. Screening for CFTR mutations should be routine for all azoospermic males, irrespective of obstructive or non-obstructive etiology, prior to proposing ICSI treatment. CFTR testing has no value in the investigation of non-azoospermic infertile males.
Language:
eng
MeSH:
Azoospermia/*diagnosis/*genetics/therapy; Case-Control Studies; Cystic Fibrosis/diagnosis/*genetics; Cystic Fibrosis Transmembrane Conductance Regulator/*genetics; DNA Mutational Analysis; Gene Frequency; Genetic Testing/methods; Heterozygote Detection; Humans; Infertility, Male/etiology/genetics/therapy; Male; Mutation; Predictive Value of Tests; Prognosis; *Sperm Injections, Intracytoplasmic
ISSN:
1556-5653 (Electronic); 0015-0282 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorMocanu, Edgaren_GB
dc.contributor.authorShattock, Richarden_GB
dc.contributor.authorBarton, Daviden_GB
dc.contributor.authorRogers, Melissaen_GB
dc.contributor.authorConroy, Ronanen_GB
dc.contributor.authorSheils, Orlaen_GB
dc.contributor.authorCollins, Claireen_GB
dc.contributor.authorMartin, Caraen_GB
dc.contributor.authorHarrison, Roberten_GB
dc.contributor.authorO'Leary, Johnen_GB
dc.date.accessioned2012-02-01T10:38:03Z-
dc.date.available2012-02-01T10:38:03Z-
dc.date.issued2012-02-01T10:38:03Z-
dc.identifier.citationFertil Steril. 2010 Nov;94(6):2448-50. Epub 2010 Apr 9.en_GB
dc.identifier.issn1556-5653 (Electronic)en_GB
dc.identifier.issn0015-0282 (Linking)en_GB
dc.identifier.pmid20381036en_GB
dc.identifier.doi10.1016/j.fertnstert.2010.02.029en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207723-
dc.description.abstractWe assessed the frequency of CFTR mutations in groups with varying degrees of sub-fertility and compared these groups to a fertile male group with proven paternity. Screening for CFTR mutations should be routine for all azoospermic males, irrespective of obstructive or non-obstructive etiology, prior to proposing ICSI treatment. CFTR testing has no value in the investigation of non-azoospermic infertile males.en_GB
dc.language.isoengen_GB
dc.subject.meshAzoospermia/*diagnosis/*genetics/therapyen_GB
dc.subject.meshCase-Control Studiesen_GB
dc.subject.meshCystic Fibrosis/diagnosis/*geneticsen_GB
dc.subject.meshCystic Fibrosis Transmembrane Conductance Regulator/*geneticsen_GB
dc.subject.meshDNA Mutational Analysisen_GB
dc.subject.meshGene Frequencyen_GB
dc.subject.meshGenetic Testing/methodsen_GB
dc.subject.meshHeterozygote Detectionen_GB
dc.subject.meshHumansen_GB
dc.subject.meshInfertility, Male/etiology/genetics/therapyen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMutationen_GB
dc.subject.meshPredictive Value of Testsen_GB
dc.subject.meshPrognosisen_GB
dc.subject.mesh*Sperm Injections, Intracytoplasmicen_GB
dc.titleAll azoospermic males should be screened for cystic fibrosis mutations before intracytoplasmic sperm injection.en_GB
dc.contributor.departmentHuman Assisted Reproduction Ireland, Rotunda Hospital, and Royal College of, Surgeons in Ireland, Dublin, Ireland. emocanu@rcsi.ieen_GB
dc.identifier.journalFertility and sterilityen_GB
dc.description.provinceLeinster-

Related articles on PubMed

All Items in Lenus, The Irish Health Repository are protected by copyright, with all rights reserved, unless otherwise indicated.