Correction and transformation of normative neurophysiological data: is there added value in the diagnosis of distal symmetrical peripheral neuropathy?

Hdl Handle:
http://hdl.handle.net/10147/207700
Title:
Correction and transformation of normative neurophysiological data: is there added value in the diagnosis of distal symmetrical peripheral neuropathy?
Authors:
Mchugh, John C; Connolly, Sean
Affiliation:
Department of Clinical Neurophysiology, St. Vincent's University Hospital, Elm, Park, Dublin 4, Ireland. drjohnmchugh@ireland.com
Citation:
Muscle Nerve. 2011 Dec;44(6):890-6. doi: 10.1002/mus.22190.
Journal:
Muscle & nerve
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207700
DOI:
10.1002/mus.22190
PubMed ID:
22102459
Abstract:
INTRODUCTION: Despite theoretical advantages, the practical impact of mathematical correction of normative electrodiagnostic data is poorly quantified. METHODS: One hundred five healthy volunteers had clinical and neurophysiological assessment. The effects of age, height, gender, weight, and body mass index were explored using stepwise regression modeling. Reference values were derived from raw and adjusted data, which were transformed to allow appropriate use of parametric statistics. The diagnostic accuracy of derived limits was tested in patients at risk of distal symmetric peripheral neuropathy (DSPN) from chemotherapy. RESULTS: The variability of our normative data was reduced by up to 69% through the use of regression modeling, but the overall benefits of mathematical correction were marginal. The most accurate reference limits were established using the 2.5th and 97.5th percentiles of the raw data. CONCLUSIONS: Stepwise statistical regression and mathematical transformation improve the distribution of normative data, but their practical impact for diagnosis of distal symmetrical polyneuropathy is small.
Language:
eng
MeSH:
Adult; Aged; Aged, 80 and over; *Data Interpretation, Statistical; Databases, Factual/statistics & numerical data; Female; Humans; Male; Middle Aged; Neural Conduction/*physiology; Peripheral Nervous System Diseases/*diagnosis/*physiopathology; Sensory Thresholds/physiology; Young Adult
ISSN:
1097-4598 (Electronic); 0148-639X (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorMchugh, John Cen_GB
dc.contributor.authorConnolly, Seanen_GB
dc.date.accessioned2012-02-01T10:35:20Z-
dc.date.available2012-02-01T10:35:20Z-
dc.date.issued2012-02-01T10:35:20Z-
dc.identifier.citationMuscle Nerve. 2011 Dec;44(6):890-6. doi: 10.1002/mus.22190.en_GB
dc.identifier.issn1097-4598 (Electronic)en_GB
dc.identifier.issn0148-639X (Linking)en_GB
dc.identifier.pmid22102459en_GB
dc.identifier.doi10.1002/mus.22190en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207700-
dc.description.abstractINTRODUCTION: Despite theoretical advantages, the practical impact of mathematical correction of normative electrodiagnostic data is poorly quantified. METHODS: One hundred five healthy volunteers had clinical and neurophysiological assessment. The effects of age, height, gender, weight, and body mass index were explored using stepwise regression modeling. Reference values were derived from raw and adjusted data, which were transformed to allow appropriate use of parametric statistics. The diagnostic accuracy of derived limits was tested in patients at risk of distal symmetric peripheral neuropathy (DSPN) from chemotherapy. RESULTS: The variability of our normative data was reduced by up to 69% through the use of regression modeling, but the overall benefits of mathematical correction were marginal. The most accurate reference limits were established using the 2.5th and 97.5th percentiles of the raw data. CONCLUSIONS: Stepwise statistical regression and mathematical transformation improve the distribution of normative data, but their practical impact for diagnosis of distal symmetrical polyneuropathy is small.en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAgeden_GB
dc.subject.meshAged, 80 and overen_GB
dc.subject.mesh*Data Interpretation, Statisticalen_GB
dc.subject.meshDatabases, Factual/statistics & numerical dataen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshNeural Conduction/*physiologyen_GB
dc.subject.meshPeripheral Nervous System Diseases/*diagnosis/*physiopathologyen_GB
dc.subject.meshSensory Thresholds/physiologyen_GB
dc.subject.meshYoung Adulten_GB
dc.titleCorrection and transformation of normative neurophysiological data: is there added value in the diagnosis of distal symmetrical peripheral neuropathy?en_GB
dc.contributor.departmentDepartment of Clinical Neurophysiology, St. Vincent's University Hospital, Elm, Park, Dublin 4, Ireland. drjohnmchugh@ireland.comen_GB
dc.identifier.journalMuscle & nerveen_GB
dc.description.provinceLeinster-

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