Hepatic transplantation outcomes for carefully selected cirrhotic patients with hepatocellular carcinoma: experience at a small- to medium-volume centre.

Hdl Handle:
http://hdl.handle.net/10147/207697
Title:
Hepatic transplantation outcomes for carefully selected cirrhotic patients with hepatocellular carcinoma: experience at a small- to medium-volume centre.
Authors:
Qasim, A; Zaman, M B; Maguire, D; Geoghegan, J; Gibney, R; Nolan, N; Traynor, O; Hegarty, J; McCormick, P A
Affiliation:
St Vincent's University Hospital, Dublin, Ireland. asgharqasim@yahoo.co.uk
Citation:
Ir J Med Sci. 2009 Dec;178(4):469-72.
Journal:
Irish journal of medical science
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207697
DOI:
10.1007/s11845-009-0333-5
PubMed ID:
19360451
Abstract:
BACKGROUND: Hepatic transplantation outcomes for cirrhotic patients with hepatocellular carcinoma (HCC) at a small- to medium-volume centre are not fully known due to relative novelty of patient selection criteria. AIM: To determine hepatic transplantation outcomes for HCC at a small- to medium-volume centre. Patients and methods Hepatocellular carcinoma patients were listed for transplantation according to the International Guideline and further categorized as those fulfilling or exceeding Milan or University of San Francisco (UCSF) criteria on explanted liver morphology. Outcomes including mortality, retransplantation, and tumour recurrence rate were analysed. RESULTS: Twenty-six patients had HCC and on explanted liver morphology, Milan and UCSF criteria met 15 and 18 patients, respectively. Patients and graft survival at 3 months, 1 and 5 years were 100, 96, 84, and 88, 84, 77%, respectively. Outcomes favoured Milan criteria but did not reach statistical significance. CONCLUSIONS: Hepatic transplantation for HCC at a small-to medium-volume transplant centre had comparable survival outcomes to high-volume centres.
Language:
eng
MeSH:
Adult; Aged; Carcinoma, Hepatocellular/complications/pathology/*surgery; Humans; Liver Cirrhosis/complications/pathology/*surgery; Liver Neoplasms/complications/pathology/*surgery; *Liver Transplantation; Middle Aged; Treatment Outcome
ISSN:
1863-4362 (Electronic); 0021-1265 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorQasim, Aen_GB
dc.contributor.authorZaman, M Ben_GB
dc.contributor.authorMaguire, Den_GB
dc.contributor.authorGeoghegan, Jen_GB
dc.contributor.authorGibney, Ren_GB
dc.contributor.authorNolan, Nen_GB
dc.contributor.authorTraynor, Oen_GB
dc.contributor.authorHegarty, Jen_GB
dc.contributor.authorMcCormick, P Aen_GB
dc.date.accessioned2012-02-01T10:35:15Z-
dc.date.available2012-02-01T10:35:15Z-
dc.date.issued2012-02-01T10:35:15Z-
dc.identifier.citationIr J Med Sci. 2009 Dec;178(4):469-72.en_GB
dc.identifier.issn1863-4362 (Electronic)en_GB
dc.identifier.issn0021-1265 (Linking)en_GB
dc.identifier.pmid19360451en_GB
dc.identifier.doi10.1007/s11845-009-0333-5en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207697-
dc.description.abstractBACKGROUND: Hepatic transplantation outcomes for cirrhotic patients with hepatocellular carcinoma (HCC) at a small- to medium-volume centre are not fully known due to relative novelty of patient selection criteria. AIM: To determine hepatic transplantation outcomes for HCC at a small- to medium-volume centre. Patients and methods Hepatocellular carcinoma patients were listed for transplantation according to the International Guideline and further categorized as those fulfilling or exceeding Milan or University of San Francisco (UCSF) criteria on explanted liver morphology. Outcomes including mortality, retransplantation, and tumour recurrence rate were analysed. RESULTS: Twenty-six patients had HCC and on explanted liver morphology, Milan and UCSF criteria met 15 and 18 patients, respectively. Patients and graft survival at 3 months, 1 and 5 years were 100, 96, 84, and 88, 84, 77%, respectively. Outcomes favoured Milan criteria but did not reach statistical significance. CONCLUSIONS: Hepatic transplantation for HCC at a small-to medium-volume transplant centre had comparable survival outcomes to high-volume centres.en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAgeden_GB
dc.subject.meshCarcinoma, Hepatocellular/complications/pathology/*surgeryen_GB
dc.subject.meshHumansen_GB
dc.subject.meshLiver Cirrhosis/complications/pathology/*surgeryen_GB
dc.subject.meshLiver Neoplasms/complications/pathology/*surgeryen_GB
dc.subject.mesh*Liver Transplantationen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshTreatment Outcomeen_GB
dc.titleHepatic transplantation outcomes for carefully selected cirrhotic patients with hepatocellular carcinoma: experience at a small- to medium-volume centre.en_GB
dc.contributor.departmentSt Vincent's University Hospital, Dublin, Ireland. asgharqasim@yahoo.co.uken_GB
dc.identifier.journalIrish journal of medical scienceen_GB
dc.description.provinceLeinster-

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