Hdl Handle:
http://hdl.handle.net/10147/207681
Title:
Methylated genes as new cancer biomarkers.
Authors:
Duffy, M J; Napieralski, R; Martens, J W M; Span, P N; Spyratos, F; Sweep, F C G J; Brunner, N; Foekens, J A; Schmitt, M
Affiliation:
Department of Pathology and Laboratory Medicine, Nuclear Medicine Laboratory, St., Vincent's University Hospital, Elm Park, Dublin 4, Ireland., Michael.J.Duffy@ucd.ie
Citation:
Eur J Cancer. 2009 Feb;45(3):335-46. Epub 2009 Jan 12.
Journal:
European journal of cancer (Oxford, England : 1990)
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207681
DOI:
10.1016/j.ejca.2008.12.008
PubMed ID:
19138839
Abstract:
Aberrant hypermethylation of promoter regions in specific genes is a key event in the formation and progression of cancer. In at least some situations, these aberrant alterations occur early in the formation of malignancy and appear to be tumour specific. Multiple reports have suggested that measurement of the methylation status of the promoter regions of specific genes can aid early detection of cancer, determine prognosis and predict therapy responses. Promising DNA methylation biomarkers include the use of methylated GSTP1 for aiding the early diagnosis of prostate cancer, methylated PITX2 for predicting outcome in lymph node-negative breast cancer patients and methylated MGMT in predicting benefit from alkylating agents in patients with glioblastomas. However, prior to clinical utilisation, these findings require validation in prospective clinical studies. Furthermore, assays for measuring gene methylation need to be standardised, simplified and evaluated in external quality assurance programmes. It is concluded that methylated genes have the potential to provide a new generation of cancer biomarkers.
Language:
eng
MeSH:
Breast Neoplasms/genetics/metabolism; CpG Islands/*genetics; DNA Methylation/*genetics; DNA, Neoplasm/*genetics/metabolism; Disease Progression; Female; Gene Expression Regulation, Neoplastic/genetics; Genetic Markers; Glioblastoma/genetics/metabolism; Humans; Lung Neoplasms/genetics/metabolism; Male; Neoplasm Proteins/blood/*genetics; Neoplasms/*genetics/metabolism; Ovarian Neoplasms/genetics/metabolism; Precancerous Conditions/blood/genetics; Promoter Regions, Genetic/genetics; Prostatic Neoplasms/genetics/metabolism; Tumor Markers, Biological/genetics
ISSN:
1879-0852 (Electronic); 0959-8049 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorDuffy, M Jen_GB
dc.contributor.authorNapieralski, Ren_GB
dc.contributor.authorMartens, J W Men_GB
dc.contributor.authorSpan, P Nen_GB
dc.contributor.authorSpyratos, Fen_GB
dc.contributor.authorSweep, F C G Jen_GB
dc.contributor.authorBrunner, Nen_GB
dc.contributor.authorFoekens, J Aen_GB
dc.contributor.authorSchmitt, Men_GB
dc.date.accessioned2012-02-01T10:34:48Z-
dc.date.available2012-02-01T10:34:48Z-
dc.date.issued2012-02-01T10:34:48Z-
dc.identifier.citationEur J Cancer. 2009 Feb;45(3):335-46. Epub 2009 Jan 12.en_GB
dc.identifier.issn1879-0852 (Electronic)en_GB
dc.identifier.issn0959-8049 (Linking)en_GB
dc.identifier.pmid19138839en_GB
dc.identifier.doi10.1016/j.ejca.2008.12.008en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207681-
dc.description.abstractAberrant hypermethylation of promoter regions in specific genes is a key event in the formation and progression of cancer. In at least some situations, these aberrant alterations occur early in the formation of malignancy and appear to be tumour specific. Multiple reports have suggested that measurement of the methylation status of the promoter regions of specific genes can aid early detection of cancer, determine prognosis and predict therapy responses. Promising DNA methylation biomarkers include the use of methylated GSTP1 for aiding the early diagnosis of prostate cancer, methylated PITX2 for predicting outcome in lymph node-negative breast cancer patients and methylated MGMT in predicting benefit from alkylating agents in patients with glioblastomas. However, prior to clinical utilisation, these findings require validation in prospective clinical studies. Furthermore, assays for measuring gene methylation need to be standardised, simplified and evaluated in external quality assurance programmes. It is concluded that methylated genes have the potential to provide a new generation of cancer biomarkers.en_GB
dc.language.isoengen_GB
dc.subject.meshBreast Neoplasms/genetics/metabolismen_GB
dc.subject.meshCpG Islands/*geneticsen_GB
dc.subject.meshDNA Methylation/*geneticsen_GB
dc.subject.meshDNA, Neoplasm/*genetics/metabolismen_GB
dc.subject.meshDisease Progressionen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshGene Expression Regulation, Neoplastic/geneticsen_GB
dc.subject.meshGenetic Markersen_GB
dc.subject.meshGlioblastoma/genetics/metabolismen_GB
dc.subject.meshHumansen_GB
dc.subject.meshLung Neoplasms/genetics/metabolismen_GB
dc.subject.meshMaleen_GB
dc.subject.meshNeoplasm Proteins/blood/*geneticsen_GB
dc.subject.meshNeoplasms/*genetics/metabolismen_GB
dc.subject.meshOvarian Neoplasms/genetics/metabolismen_GB
dc.subject.meshPrecancerous Conditions/blood/geneticsen_GB
dc.subject.meshPromoter Regions, Genetic/geneticsen_GB
dc.subject.meshProstatic Neoplasms/genetics/metabolismen_GB
dc.subject.meshTumor Markers, Biological/geneticsen_GB
dc.titleMethylated genes as new cancer biomarkers.en_GB
dc.contributor.departmentDepartment of Pathology and Laboratory Medicine, Nuclear Medicine Laboratory, St., Vincent's University Hospital, Elm Park, Dublin 4, Ireland., Michael.J.Duffy@ucd.ieen_GB
dc.identifier.journalEuropean journal of cancer (Oxford, England : 1990)en_GB
dc.description.provinceLeinster-

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