Psoriatic arthritis: from pathogenesis to therapy.

Hdl Handle:
http://hdl.handle.net/10147/207672
Title:
Psoriatic arthritis: from pathogenesis to therapy.
Authors:
Fitzgerald, Oliver; Winchester, Robert
Affiliation:
Department of Rheumatology, St Vincent's University Hospital, Elm Park, Dublin 4,, Ireland. oliver.fitzgerald@ucd.ie
Citation:
Arthritis Res Ther. 2009;11(1):214. Epub 2009 Feb 12.
Journal:
Arthritis research & therapy
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207672
DOI:
10.1186/ar2580
PubMed ID:
19232079
Abstract:
Psoriatic arthritis is a multigenic autoimmune disease that involves synovial tissue, entheseal sites and skin, and that may result in significant joint damage. Although there are no diagnostic tests for psoriatic arthritis, research has identified consistent features that help to distinguish the condition from other common rheumatic diseases. Comparison of HLA-B and HLA-C regions in psoriatic arthritis with those in psoriasis without joint involvement demonstrates significant differences, such that psoriatic arthritis cannot be viewed simply as a subset of genetically homogeneous psoriasis. T-cell receptor phenotypic studies have failed to identify antigen-driven clones, and an alternative hypothesis for CD8 stimulation involving innate immune signals is proposed. Finally, imaging studies have highlighted entheseal involvement in psoriatic arthritis, and it is possible that entheseal-derived antigens may trigger an immune response that is critically involved in disease pathogenesis.
Language:
eng
MeSH:
Arthritis, Psoriatic/*genetics/*immunology/*therapy; Genetic Predisposition to Disease; Humans; Immunologic Factors/therapeutic use
ISSN:
1478-6362 (Electronic); 1478-6354 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorFitzgerald, Oliveren_GB
dc.contributor.authorWinchester, Roberten_GB
dc.date.accessioned2012-02-01T10:34:33Z-
dc.date.available2012-02-01T10:34:33Z-
dc.date.issued2012-02-01T10:34:33Z-
dc.identifier.citationArthritis Res Ther. 2009;11(1):214. Epub 2009 Feb 12.en_GB
dc.identifier.issn1478-6362 (Electronic)en_GB
dc.identifier.issn1478-6354 (Linking)en_GB
dc.identifier.pmid19232079en_GB
dc.identifier.doi10.1186/ar2580en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207672-
dc.description.abstractPsoriatic arthritis is a multigenic autoimmune disease that involves synovial tissue, entheseal sites and skin, and that may result in significant joint damage. Although there are no diagnostic tests for psoriatic arthritis, research has identified consistent features that help to distinguish the condition from other common rheumatic diseases. Comparison of HLA-B and HLA-C regions in psoriatic arthritis with those in psoriasis without joint involvement demonstrates significant differences, such that psoriatic arthritis cannot be viewed simply as a subset of genetically homogeneous psoriasis. T-cell receptor phenotypic studies have failed to identify antigen-driven clones, and an alternative hypothesis for CD8 stimulation involving innate immune signals is proposed. Finally, imaging studies have highlighted entheseal involvement in psoriatic arthritis, and it is possible that entheseal-derived antigens may trigger an immune response that is critically involved in disease pathogenesis.en_GB
dc.language.isoengen_GB
dc.subject.meshArthritis, Psoriatic/*genetics/*immunology/*therapyen_GB
dc.subject.meshGenetic Predisposition to Diseaseen_GB
dc.subject.meshHumansen_GB
dc.subject.meshImmunologic Factors/therapeutic useen_GB
dc.titlePsoriatic arthritis: from pathogenesis to therapy.en_GB
dc.contributor.departmentDepartment of Rheumatology, St Vincent's University Hospital, Elm Park, Dublin 4,, Ireland. oliver.fitzgerald@ucd.ieen_GB
dc.identifier.journalArthritis research & therapyen_GB
dc.description.provinceLeinster-

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