Hdl Handle:
http://hdl.handle.net/10147/207659
Title:
A pernicious leucoencephalopathy.
Authors:
Molloy, A; Cawley, N; Ali, E; Connolly, S; Tubridy, N; Hutchinson, M
Affiliation:
Department of Neurology, St Vincent's University Hospital, Elm Park, Dublin 4.
Citation:
Ir Med J. 2009 Oct;102(9):292-4.
Journal:
Irish medical journal
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207659
PubMed ID:
19902649
Abstract:
Pernicious anaemia may manifest various neurological symptoms and signs ranging from the subtle to the dramatic. We describe a young man with cobalamin deficiency presenting with sensorimotor deficits, ataxia, dysarthria, mild cognitive deterioration and altered mood of insidious onset. The MRI brain findings were in keeping with a leucoencephalopathy without evidence of MRI changes in the spinal cord. This constellation of features has been reported rarely. His response to treatment as well as the marked improvement of the leucoencephalopathy on imaging suggests at least partial reversibility of the neurological deficits.
Language:
eng
MeSH:
Adult; Anemia, Pernicious/*complications/etiology; Humans; Hydroxocobalamin/therapeutic use; Leukoencephalopathies/*diagnosis/etiology; Magnetic Resonance Imaging; Male; Vitamin B 12 Deficiency/*complications/etiology; Vitamin B Complex/therapeutic use
ISSN:
0332-3102 (Print); 0332-3102 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorMolloy, Aen_GB
dc.contributor.authorCawley, Nen_GB
dc.contributor.authorAli, Een_GB
dc.contributor.authorConnolly, Sen_GB
dc.contributor.authorTubridy, Nen_GB
dc.contributor.authorHutchinson, Men_GB
dc.date.accessioned2012-02-01T10:34:13Z-
dc.date.available2012-02-01T10:34:13Z-
dc.date.issued2012-02-01T10:34:13Z-
dc.identifier.citationIr Med J. 2009 Oct;102(9):292-4.en_GB
dc.identifier.issn0332-3102 (Print)en_GB
dc.identifier.issn0332-3102 (Linking)en_GB
dc.identifier.pmid19902649en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207659-
dc.description.abstractPernicious anaemia may manifest various neurological symptoms and signs ranging from the subtle to the dramatic. We describe a young man with cobalamin deficiency presenting with sensorimotor deficits, ataxia, dysarthria, mild cognitive deterioration and altered mood of insidious onset. The MRI brain findings were in keeping with a leucoencephalopathy without evidence of MRI changes in the spinal cord. This constellation of features has been reported rarely. His response to treatment as well as the marked improvement of the leucoencephalopathy on imaging suggests at least partial reversibility of the neurological deficits.en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAnemia, Pernicious/*complications/etiologyen_GB
dc.subject.meshHumansen_GB
dc.subject.meshHydroxocobalamin/therapeutic useen_GB
dc.subject.meshLeukoencephalopathies/*diagnosis/etiologyen_GB
dc.subject.meshMagnetic Resonance Imagingen_GB
dc.subject.meshMaleen_GB
dc.subject.meshVitamin B 12 Deficiency/*complications/etiologyen_GB
dc.subject.meshVitamin B Complex/therapeutic useen_GB
dc.titleA pernicious leucoencephalopathy.en_GB
dc.contributor.departmentDepartment of Neurology, St Vincent's University Hospital, Elm Park, Dublin 4.en_GB
dc.identifier.journalIrish medical journalen_GB
dc.description.provinceLeinster-

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