Alcohol misuse in patients with psoriasis: identification and relationship to disease severity and psychological distress.

Hdl Handle:
http://hdl.handle.net/10147/207649
Title:
Alcohol misuse in patients with psoriasis: identification and relationship to disease severity and psychological distress.
Authors:
McAleer, M A; Mason, D L; Cunningham, S; O'Shea, S J; McCormick, P A; Stone, C; Collins, P; Rogers, S; Kirby, B
Affiliation:
Department of Dermatology, St Vincent's University Hospital, Elm Park, Dublin 4, , Ireland.
Citation:
Br J Dermatol. 2011 Jun;164(6):1256-61. doi: 10.1111/j.1365-2133.2011.10345.x.
Journal:
The British journal of dermatology
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207649
DOI:
10.1111/j.1365-2133.2011.10345.x
PubMed ID:
21457207
Abstract:
BACKGROUND: Moderate to severe psoriasis is associated with increased alcohol intake and excessive mortality from alcohol-related causes. Alcohol biomarkers provide an objective measure of alcohol consumption. Carbohydrate-deficient transferrin (CDT) is the single most sensitive and specific alcohol biomarker. OBJECTIVES: To assess alcohol consumption in a cohort of patients with moderate to severe psoriasis using standard alcohol screening questionnaires and biomarkers. We investigated whether there was an association between alcohol intake, anxiety, depression and disease severity. METHODS: Consecutive patients with chronic plaque psoriasis were recruited and completed a range of anonymized assessments. Psoriasis severity, anxiety and depression, and the impact of psoriasis on quality of life were assessed. Alcohol screening questionnaires were administered. Blood specimens were taken and gamma-glutamyltransferase (gammaGT) and CDT were measured. RESULTS: A total of 135 patients completed the study. Using validated questionnaires, between 22% and 32% had difficulties with alcohol. Seven per cent had CDT > 1.6% indicating a heavy alcohol intake. The Alcohol Use Disorders Identification Test (AUDIT) questionnaire was superior to other validated questionnaires in detecting alcohol misuse. There were no significant associations between measures of excessive alcohol consumption and disease severity. Excessive alcohol intake as measured by the CAGE questionnaire was associated with increased depression (P = 0.001) but other measures of alcohol excess did not correlate with psychological distress. Men had significantly more difficulties with alcohol than women (P < 0.001). CONCLUSION: Alcohol misuse is common in patients with moderate to severe psoriasis. Screening with the AUDIT questionnaire and CDT may allow the identification of patients who are misusing alcohol and allow appropriate intervention.
Language:
eng
MeSH:
Adult; Age Factors; Aged; Alcohol Drinking/blood/psychology; Alcohol-Related Disorders/diagnosis/*etiology/psychology; Anxiety Disorders/etiology; Biological Markers/metabolism; Depressive Disorder/etiology; Epidemiologic Methods; Female; Humans; Male; Middle Aged; Psoriasis/*psychology; Quality of Life; Sex Factors; Stress, Psychological/*etiology; Transferrin/analogs & derivatives/metabolism; gamma-Glutamyltransferase/metabolism
ISSN:
1365-2133 (Electronic); 0007-0963 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorMcAleer, M Aen_GB
dc.contributor.authorMason, D Len_GB
dc.contributor.authorCunningham, Sen_GB
dc.contributor.authorO'Shea, S Jen_GB
dc.contributor.authorMcCormick, P Aen_GB
dc.contributor.authorStone, Cen_GB
dc.contributor.authorCollins, Pen_GB
dc.contributor.authorRogers, Sen_GB
dc.contributor.authorKirby, Ben_GB
dc.date.accessioned2012-02-01T10:33:56Z-
dc.date.available2012-02-01T10:33:56Z-
dc.date.issued2012-02-01T10:33:56Z-
dc.identifier.citationBr J Dermatol. 2011 Jun;164(6):1256-61. doi: 10.1111/j.1365-2133.2011.10345.x.en_GB
dc.identifier.issn1365-2133 (Electronic)en_GB
dc.identifier.issn0007-0963 (Linking)en_GB
dc.identifier.pmid21457207en_GB
dc.identifier.doi10.1111/j.1365-2133.2011.10345.xen_GB
dc.identifier.urihttp://hdl.handle.net/10147/207649-
dc.description.abstractBACKGROUND: Moderate to severe psoriasis is associated with increased alcohol intake and excessive mortality from alcohol-related causes. Alcohol biomarkers provide an objective measure of alcohol consumption. Carbohydrate-deficient transferrin (CDT) is the single most sensitive and specific alcohol biomarker. OBJECTIVES: To assess alcohol consumption in a cohort of patients with moderate to severe psoriasis using standard alcohol screening questionnaires and biomarkers. We investigated whether there was an association between alcohol intake, anxiety, depression and disease severity. METHODS: Consecutive patients with chronic plaque psoriasis were recruited and completed a range of anonymized assessments. Psoriasis severity, anxiety and depression, and the impact of psoriasis on quality of life were assessed. Alcohol screening questionnaires were administered. Blood specimens were taken and gamma-glutamyltransferase (gammaGT) and CDT were measured. RESULTS: A total of 135 patients completed the study. Using validated questionnaires, between 22% and 32% had difficulties with alcohol. Seven per cent had CDT > 1.6% indicating a heavy alcohol intake. The Alcohol Use Disorders Identification Test (AUDIT) questionnaire was superior to other validated questionnaires in detecting alcohol misuse. There were no significant associations between measures of excessive alcohol consumption and disease severity. Excessive alcohol intake as measured by the CAGE questionnaire was associated with increased depression (P = 0.001) but other measures of alcohol excess did not correlate with psychological distress. Men had significantly more difficulties with alcohol than women (P < 0.001). CONCLUSION: Alcohol misuse is common in patients with moderate to severe psoriasis. Screening with the AUDIT questionnaire and CDT may allow the identification of patients who are misusing alcohol and allow appropriate intervention.en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAge Factorsen_GB
dc.subject.meshAgeden_GB
dc.subject.meshAlcohol Drinking/blood/psychologyen_GB
dc.subject.meshAlcohol-Related Disorders/diagnosis/*etiology/psychologyen_GB
dc.subject.meshAnxiety Disorders/etiologyen_GB
dc.subject.meshBiological Markers/metabolismen_GB
dc.subject.meshDepressive Disorder/etiologyen_GB
dc.subject.meshEpidemiologic Methodsen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshPsoriasis/*psychologyen_GB
dc.subject.meshQuality of Lifeen_GB
dc.subject.meshSex Factorsen_GB
dc.subject.meshStress, Psychological/*etiologyen_GB
dc.subject.meshTransferrin/analogs & derivatives/metabolismen_GB
dc.subject.meshgamma-Glutamyltransferase/metabolismen_GB
dc.titleAlcohol misuse in patients with psoriasis: identification and relationship to disease severity and psychological distress.en_GB
dc.contributor.departmentDepartment of Dermatology, St Vincent's University Hospital, Elm Park, Dublin 4, , Ireland.en_GB
dc.identifier.journalThe British journal of dermatologyen_GB
dc.description.provinceLeinster-
All Items in Lenus, The Irish Health Repository are protected by copyright, with all rights reserved, unless otherwise indicated.