Time course and recovery of arterial blood gases during exacerbations in adults with Cystic Fibrosis.

Hdl Handle:
http://hdl.handle.net/10147/207647
Title:
Time course and recovery of arterial blood gases during exacerbations in adults with Cystic Fibrosis.
Authors:
Waterhouse, D F; McLaughlin, A M; Gallagher, C G
Affiliation:
Department of Respiratory Medicine, St. Vincent's University Hospital, Ireland.
Citation:
J Cyst Fibros. 2009 Jan;8(1):9-13. Epub 2008 Aug 20.
Journal:
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis, Society
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207647
DOI:
10.1016/j.jcf.2008.07.001
PubMed ID:
18718821
Abstract:
INTRODUCTION: Hypoxia and hypercapnia are closely linked to morbidity and mortality in patients with Cystic Fibrosis (CF). The aims of this study were to describe the changes in blood gases during and following an acute pulmonary exacerbation in adults with CF. METHODS: We performed a prospective observational study of patients with CF admitted for management of an acute exacerbation. Blood gas and spirometric analysis was performed on admission, throughout the treatment period, and 31 days after discharge (day 45). RESULTS: At presentation, eight of nineteen patients had evidence of either hypoxia (PaO(2)<8 kPa) and/or hypercapnia (PaCO(2)>6.6 kPa). Blood gas parameters stabilized following two weeks of intravenous antibiotic therapy, with little difference evident in between treatment completion and subsequent review following discharge. Hypercapnia reversed in three patients, with persistent hypercapnia evident in two patients. CONCLUSION: In our study group, hypoxemia and hypercapnia were frequently observed at presentation of the acute exacerbation. Blood gases stabilized following two weeks of intravenous antibiotic therapy, with arterial PCO(2) one month following hospital discharge generally similar to that at time of discharge.
Language:
eng
MeSH:
Adult; Anoxia/blood/*etiology; Anti-Bacterial Agents/therapeutic use; *Blood Gas Analysis; Bronchodilator Agents/therapeutic use; Cystic Fibrosis/*blood/*complications/drug therapy; Disease Progression; Drug Therapy, Combination; Female; Humans; Hypercapnia/blood/*etiology; Male; Middle Aged; Prospective Studies; Recovery of Function; Spirometry; Young Adult
ISSN:
1569-1993 (Print); 1569-1993 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorWaterhouse, D Fen_GB
dc.contributor.authorMcLaughlin, A Men_GB
dc.contributor.authorGallagher, C Gen_GB
dc.date.accessioned2012-02-01T10:33:53Z-
dc.date.available2012-02-01T10:33:53Z-
dc.date.issued2012-02-01T10:33:53Z-
dc.identifier.citationJ Cyst Fibros. 2009 Jan;8(1):9-13. Epub 2008 Aug 20.en_GB
dc.identifier.issn1569-1993 (Print)en_GB
dc.identifier.issn1569-1993 (Linking)en_GB
dc.identifier.pmid18718821en_GB
dc.identifier.doi10.1016/j.jcf.2008.07.001en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207647-
dc.description.abstractINTRODUCTION: Hypoxia and hypercapnia are closely linked to morbidity and mortality in patients with Cystic Fibrosis (CF). The aims of this study were to describe the changes in blood gases during and following an acute pulmonary exacerbation in adults with CF. METHODS: We performed a prospective observational study of patients with CF admitted for management of an acute exacerbation. Blood gas and spirometric analysis was performed on admission, throughout the treatment period, and 31 days after discharge (day 45). RESULTS: At presentation, eight of nineteen patients had evidence of either hypoxia (PaO(2)<8 kPa) and/or hypercapnia (PaCO(2)>6.6 kPa). Blood gas parameters stabilized following two weeks of intravenous antibiotic therapy, with little difference evident in between treatment completion and subsequent review following discharge. Hypercapnia reversed in three patients, with persistent hypercapnia evident in two patients. CONCLUSION: In our study group, hypoxemia and hypercapnia were frequently observed at presentation of the acute exacerbation. Blood gases stabilized following two weeks of intravenous antibiotic therapy, with arterial PCO(2) one month following hospital discharge generally similar to that at time of discharge.en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAnoxia/blood/*etiologyen_GB
dc.subject.meshAnti-Bacterial Agents/therapeutic useen_GB
dc.subject.mesh*Blood Gas Analysisen_GB
dc.subject.meshBronchodilator Agents/therapeutic useen_GB
dc.subject.meshCystic Fibrosis/*blood/*complications/drug therapyen_GB
dc.subject.meshDisease Progressionen_GB
dc.subject.meshDrug Therapy, Combinationen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshHypercapnia/blood/*etiologyen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshProspective Studiesen_GB
dc.subject.meshRecovery of Functionen_GB
dc.subject.meshSpirometryen_GB
dc.subject.meshYoung Adulten_GB
dc.titleTime course and recovery of arterial blood gases during exacerbations in adults with Cystic Fibrosis.en_GB
dc.contributor.departmentDepartment of Respiratory Medicine, St. Vincent's University Hospital, Ireland.en_GB
dc.identifier.journalJournal of cystic fibrosis : official journal of the European Cystic Fibrosis, Societyen_GB
dc.description.provinceLeinster-

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