Hdl Handle:
http://hdl.handle.net/10147/207641
Title:
Estrogen and gastrointestinal malignancy.
Authors:
Hogan, A M; Collins, D; Baird, A W; Winter, D C
Affiliation:
Institute for Clinical Outcomes Research and Education (iCORE), St. Vincent's, University Hospital, Elm Park, Dublin 4, Ireland. Aislinghogan@yahoo.com
Citation:
Mol Cell Endocrinol. 2009 Aug 13;307(1-2):19-24. Epub 2009 Apr 1.
Journal:
Molecular and cellular endocrinology
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207641
DOI:
10.1016/j.mce.2009.03.016
PubMed ID:
19524122
Abstract:
The concept that E2 exerts an effect on the gastrointestinal tract is not new and its actions on intestinal mucosa have been investigated for at least three decades. An attempt to consolidate results of these investigations generates more questions than answers, thus suggesting that many unexplored avenues remain and that the full capabilities of this steroid hormone are far from understood. Evidence of its role in esophageal, gastric and gallbladder cancers is confusing and often equivocal. The most compelling evidence regards the protective role conferred by estrogen (or perhaps ERbeta) against the development and proliferation of colon cancer. Not only has the effect been described but also many mechanisms of action have been explored. It is likely that, along with surgery, chemotherapy and radiotherapy, hormonal manipulation will play an integral role in colon cancer management in the very near future.
Language:
eng
MeSH:
Colonic Neoplasms/metabolism; Esophageal Neoplasms/metabolism; Estrogens/*metabolism; Gallbladder Neoplasms/metabolism; Gastrointestinal Neoplasms/*metabolism; Humans; Stomach Neoplasms/metabolism
ISSN:
1872-8057 (Electronic); 0303-7207 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorHogan, A Men_GB
dc.contributor.authorCollins, Den_GB
dc.contributor.authorBaird, A Wen_GB
dc.contributor.authorWinter, D Cen_GB
dc.date.accessioned2012-02-01T10:33:41Z-
dc.date.available2012-02-01T10:33:41Z-
dc.date.issued2012-02-01T10:33:41Z-
dc.identifier.citationMol Cell Endocrinol. 2009 Aug 13;307(1-2):19-24. Epub 2009 Apr 1.en_GB
dc.identifier.issn1872-8057 (Electronic)en_GB
dc.identifier.issn0303-7207 (Linking)en_GB
dc.identifier.pmid19524122en_GB
dc.identifier.doi10.1016/j.mce.2009.03.016en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207641-
dc.description.abstractThe concept that E2 exerts an effect on the gastrointestinal tract is not new and its actions on intestinal mucosa have been investigated for at least three decades. An attempt to consolidate results of these investigations generates more questions than answers, thus suggesting that many unexplored avenues remain and that the full capabilities of this steroid hormone are far from understood. Evidence of its role in esophageal, gastric and gallbladder cancers is confusing and often equivocal. The most compelling evidence regards the protective role conferred by estrogen (or perhaps ERbeta) against the development and proliferation of colon cancer. Not only has the effect been described but also many mechanisms of action have been explored. It is likely that, along with surgery, chemotherapy and radiotherapy, hormonal manipulation will play an integral role in colon cancer management in the very near future.en_GB
dc.language.isoengen_GB
dc.subject.meshColonic Neoplasms/metabolismen_GB
dc.subject.meshEsophageal Neoplasms/metabolismen_GB
dc.subject.meshEstrogens/*metabolismen_GB
dc.subject.meshGallbladder Neoplasms/metabolismen_GB
dc.subject.meshGastrointestinal Neoplasms/*metabolismen_GB
dc.subject.meshHumansen_GB
dc.subject.meshStomach Neoplasms/metabolismen_GB
dc.titleEstrogen and gastrointestinal malignancy.en_GB
dc.contributor.departmentInstitute for Clinical Outcomes Research and Education (iCORE), St. Vincent's, University Hospital, Elm Park, Dublin 4, Ireland. Aislinghogan@yahoo.comen_GB
dc.identifier.journalMolecular and cellular endocrinologyen_GB
dc.description.provinceLeinster-

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