T cells in multiple sclerosis and experimental autoimmune encephalomyelitis.

Hdl Handle:
http://hdl.handle.net/10147/207632
Title:
T cells in multiple sclerosis and experimental autoimmune encephalomyelitis.
Authors:
Fletcher, J M; Lalor, S J; Sweeney, C M; Tubridy, N; Mills, K H G
Affiliation:
Immune Regulation Research Group, School of Biochemistry and Immunology, Trinity , College, St Vincent's University Hospital, Dublin, Ireland.
Citation:
Clin Exp Immunol. 2010 Oct;162(1):1-11. doi: 10.1111/j.1365-2249.2010.04143.x.
Journal:
Clinical and experimental immunology
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207632
DOI:
10.1111/j.1365-2249.2010.04143.x
PubMed ID:
20682002
Abstract:
Multiple sclerosis (MS) is a demyelinating inflammatory disorder of the central nervous system (CNS), which involves autoimmune responses to myelin antigens. Studies in experimental autoimmune encephalomyelitis (EAE), an animal model for MS, have provided convincing evidence that T cells specific for self-antigens mediate pathology in these diseases. Until recently, T helper type 1 (Th1) cells were thought to be the main effector T cells responsible for the autoimmune inflammation. However more recent studies have highlighted an important pathogenic role for CD4(+) T cells that secrete interleukin (IL)-17, termed Th17, but also IL-17-secreting gammadelta T cells in EAE as well as other autoimmune and chronic inflammatory conditions. This has prompted intensive study of the induction, function and regulation of IL-17-producing T cells in MS and EAE. In this paper, we review the contribution of Th1, Th17, gammadelta, CD8(+) and regulatory T cells as well as the possible development of new therapeutic approaches for MS based on manipulating these T cell subtypes.
Language:
eng
MeSH:
Animals; Cell Differentiation/immunology; Encephalomyelitis, Autoimmune, Experimental/*immunology/pathology; Humans; Interleukin-17/immunology/metabolism; Models, Immunological; Multiple Sclerosis/*immunology/pathology; T-Lymphocytes/*immunology/metabolism; T-Lymphocytes, Helper-Inducer/immunology/metabolism; Th1 Cells/cytology/*immunology/metabolism
ISSN:
1365-2249 (Electronic); 0009-9104 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorFletcher, J Men_GB
dc.contributor.authorLalor, S Jen_GB
dc.contributor.authorSweeney, C Men_GB
dc.contributor.authorTubridy, Nen_GB
dc.contributor.authorMills, K H Gen_GB
dc.date.accessioned2012-02-01T10:33:25Z-
dc.date.available2012-02-01T10:33:25Z-
dc.date.issued2012-02-01T10:33:25Z-
dc.identifier.citationClin Exp Immunol. 2010 Oct;162(1):1-11. doi: 10.1111/j.1365-2249.2010.04143.x.en_GB
dc.identifier.issn1365-2249 (Electronic)en_GB
dc.identifier.issn0009-9104 (Linking)en_GB
dc.identifier.pmid20682002en_GB
dc.identifier.doi10.1111/j.1365-2249.2010.04143.xen_GB
dc.identifier.urihttp://hdl.handle.net/10147/207632-
dc.description.abstractMultiple sclerosis (MS) is a demyelinating inflammatory disorder of the central nervous system (CNS), which involves autoimmune responses to myelin antigens. Studies in experimental autoimmune encephalomyelitis (EAE), an animal model for MS, have provided convincing evidence that T cells specific for self-antigens mediate pathology in these diseases. Until recently, T helper type 1 (Th1) cells were thought to be the main effector T cells responsible for the autoimmune inflammation. However more recent studies have highlighted an important pathogenic role for CD4(+) T cells that secrete interleukin (IL)-17, termed Th17, but also IL-17-secreting gammadelta T cells in EAE as well as other autoimmune and chronic inflammatory conditions. This has prompted intensive study of the induction, function and regulation of IL-17-producing T cells in MS and EAE. In this paper, we review the contribution of Th1, Th17, gammadelta, CD8(+) and regulatory T cells as well as the possible development of new therapeutic approaches for MS based on manipulating these T cell subtypes.en_GB
dc.language.isoengen_GB
dc.subject.meshAnimalsen_GB
dc.subject.meshCell Differentiation/immunologyen_GB
dc.subject.meshEncephalomyelitis, Autoimmune, Experimental/*immunology/pathologyen_GB
dc.subject.meshHumansen_GB
dc.subject.meshInterleukin-17/immunology/metabolismen_GB
dc.subject.meshModels, Immunologicalen_GB
dc.subject.meshMultiple Sclerosis/*immunology/pathologyen_GB
dc.subject.meshT-Lymphocytes/*immunology/metabolismen_GB
dc.subject.meshT-Lymphocytes, Helper-Inducer/immunology/metabolismen_GB
dc.subject.meshTh1 Cells/cytology/*immunology/metabolismen_GB
dc.titleT cells in multiple sclerosis and experimental autoimmune encephalomyelitis.en_GB
dc.contributor.departmentImmune Regulation Research Group, School of Biochemistry and Immunology, Trinity , College, St Vincent's University Hospital, Dublin, Ireland.en_GB
dc.identifier.journalClinical and experimental immunologyen_GB
dc.description.provinceLeinster-

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