Hdl Handle:
http://hdl.handle.net/10147/207608
Title:
Treatment and outcomes of anorectal melanoma.
Authors:
Heeney, Anna; Mulsow, Jurgen; Hyland, John M P
Affiliation:
Department of Colorectal Surgery, St. Vincent's University Hospital, Dublin 4,, Ireland. annaheeney@rcsi.ie
Citation:
Surgeon. 2011 Feb;9(1):27-32. Epub 2010 Aug 19.
Journal:
The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207608
DOI:
10.1016/j.surge.2010.07.007
PubMed ID:
21195328
Abstract:
INTRODUCTION: anorectal melanoma is an uncommon disease constituting less than 3% of all melanomas. Due to its rarity, there are a lack of randomized control trials regarding appropriate management and current evidence is based mainly on retrospective studies. METHODS: in view of the controversial surgical treatment of anorectal melanoma, we review the most published literature in an attempt to elucidate its typical clinical features along with current thinking with respect to management approaches to this aggressive disease. Using the keywords "anorectal" and "malignant melanoma", a medline search of all articles in English was performed and the relevant articles procured. Additional references were retrieved by cross reference from key articles. RESULTS: anorectal melanoma affects the elderly with a slight preponderance for females. It commonly presents disguised as benign disease with local bleeding or suspicion for haemorrhoidal disease. There is no convincing evidence to indicate that radical resection of primary anorectal melanoma is associated with improvement in local control or survival, and local excision is an acceptable treatment option. CONCLUSION: optimum management depends on several factors and the therapeutic goals should be to lengthen survival and preserve quality-of-life. Given that wide local excision is a more limited intervention with comparable survival it should be considered as the initial treatment choice. Unfortunately prognosis for patients with this disease remains poor despite choice of treatment strategy with overall five year disease-free survival less than twenty percent in most studies.
Language:
eng
MeSH:
Adult; Aged; Aged, 80 and over; Anus Neoplasms/diagnosis/pathology/therapy; Female; Humans; Male; *Melanoma/diagnosis/pathology/therapy; Middle Aged; *Rectal Neoplasms/diagnosis/pathology/therapy; Treatment Outcome
ISSN:
1479-666X (Print); 1479-666X (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorHeeney, Annaen_GB
dc.contributor.authorMulsow, Jurgenen_GB
dc.contributor.authorHyland, John M Pen_GB
dc.date.accessioned2012-02-01T10:32:45Z-
dc.date.available2012-02-01T10:32:45Z-
dc.date.issued2012-02-01T10:32:45Z-
dc.identifier.citationSurgeon. 2011 Feb;9(1):27-32. Epub 2010 Aug 19.en_GB
dc.identifier.issn1479-666X (Print)en_GB
dc.identifier.issn1479-666X (Linking)en_GB
dc.identifier.pmid21195328en_GB
dc.identifier.doi10.1016/j.surge.2010.07.007en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207608-
dc.description.abstractINTRODUCTION: anorectal melanoma is an uncommon disease constituting less than 3% of all melanomas. Due to its rarity, there are a lack of randomized control trials regarding appropriate management and current evidence is based mainly on retrospective studies. METHODS: in view of the controversial surgical treatment of anorectal melanoma, we review the most published literature in an attempt to elucidate its typical clinical features along with current thinking with respect to management approaches to this aggressive disease. Using the keywords "anorectal" and "malignant melanoma", a medline search of all articles in English was performed and the relevant articles procured. Additional references were retrieved by cross reference from key articles. RESULTS: anorectal melanoma affects the elderly with a slight preponderance for females. It commonly presents disguised as benign disease with local bleeding or suspicion for haemorrhoidal disease. There is no convincing evidence to indicate that radical resection of primary anorectal melanoma is associated with improvement in local control or survival, and local excision is an acceptable treatment option. CONCLUSION: optimum management depends on several factors and the therapeutic goals should be to lengthen survival and preserve quality-of-life. Given that wide local excision is a more limited intervention with comparable survival it should be considered as the initial treatment choice. Unfortunately prognosis for patients with this disease remains poor despite choice of treatment strategy with overall five year disease-free survival less than twenty percent in most studies.en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAgeden_GB
dc.subject.meshAged, 80 and overen_GB
dc.subject.meshAnus Neoplasms/diagnosis/pathology/therapyen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshMaleen_GB
dc.subject.mesh*Melanoma/diagnosis/pathology/therapyen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.mesh*Rectal Neoplasms/diagnosis/pathology/therapyen_GB
dc.subject.meshTreatment Outcomeen_GB
dc.titleTreatment and outcomes of anorectal melanoma.en_GB
dc.contributor.departmentDepartment of Colorectal Surgery, St. Vincent's University Hospital, Dublin 4,, Ireland. annaheeney@rcsi.ieen_GB
dc.identifier.journalThe surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Irelanden_GB
dc.description.provinceLeinster-

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