Hdl Handle:
http://hdl.handle.net/10147/207595
Title:
The role of ADAMs in disease pathophysiology.
Authors:
Duffy, Michael J; McKiernan, Eadaoin; O'Donovan, Norma; McGowan, Patricia M
Affiliation:
Department of Pathology and Laboratory Medicine, St. Vincent's University, Hospital, Dublin 4, Ireland. Michael.J.Duffy@ucd.ie
Citation:
Clin Chim Acta. 2009 May;403(1-2):31-6.
Journal:
Clinica chimica acta; international journal of clinical chemistry
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207595
PubMed ID:
19408347
Abstract:
The ADAMs are a family of multidomain transmembrane and secreted proteins involved in both proteolysis and cell adhesion. Altered expression of specific ADAMs is implicated in the pathophysiology of several diseases including rheumatoid arthritis, Alzheimer's disease, cardiac hypertrophy, asthma and cancer. Of these different diseases, it is in cancer where most research has been carried out. Multiple ADAMs, including ADAM-9, ADAM-10, ADAM-12, ADAM-15 and ADAM-17, have been shown to play a role in either cancer formation or progression. Consistent with these findings, increased expression of specific ADAMs in several cancer types was found to correlate with features of aggressive disease and poor prognosis. Currently, selective ADAM inhibitors against ADAM-10 and ADAM-17 are undergoing clinical trials for the treatment of cancer. Further work is required in order to establish a causative role for ADAMs in rheumatoid arthritis, Alzheimer's disease, cardiac hypertrophy and asthma.
Language:
eng
MeSH:
ADAM Proteins/chemistry/*metabolism; Amino Acid Sequence; Animals; Cell Line; *Disease; Humans
ISSN:
1873-3492 (Electronic); 0009-8981 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorDuffy, Michael Jen_GB
dc.contributor.authorMcKiernan, Eadaoinen_GB
dc.contributor.authorO'Donovan, Normaen_GB
dc.contributor.authorMcGowan, Patricia Men_GB
dc.date.accessioned2012-02-01T10:32:23Z-
dc.date.available2012-02-01T10:32:23Z-
dc.date.issued2012-02-01T10:32:23Z-
dc.identifier.citationClin Chim Acta. 2009 May;403(1-2):31-6.en_GB
dc.identifier.issn1873-3492 (Electronic)en_GB
dc.identifier.issn0009-8981 (Linking)en_GB
dc.identifier.pmid19408347en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207595-
dc.description.abstractThe ADAMs are a family of multidomain transmembrane and secreted proteins involved in both proteolysis and cell adhesion. Altered expression of specific ADAMs is implicated in the pathophysiology of several diseases including rheumatoid arthritis, Alzheimer's disease, cardiac hypertrophy, asthma and cancer. Of these different diseases, it is in cancer where most research has been carried out. Multiple ADAMs, including ADAM-9, ADAM-10, ADAM-12, ADAM-15 and ADAM-17, have been shown to play a role in either cancer formation or progression. Consistent with these findings, increased expression of specific ADAMs in several cancer types was found to correlate with features of aggressive disease and poor prognosis. Currently, selective ADAM inhibitors against ADAM-10 and ADAM-17 are undergoing clinical trials for the treatment of cancer. Further work is required in order to establish a causative role for ADAMs in rheumatoid arthritis, Alzheimer's disease, cardiac hypertrophy and asthma.en_GB
dc.language.isoengen_GB
dc.subject.meshADAM Proteins/chemistry/*metabolismen_GB
dc.subject.meshAmino Acid Sequenceen_GB
dc.subject.meshAnimalsen_GB
dc.subject.meshCell Lineen_GB
dc.subject.mesh*Diseaseen_GB
dc.subject.meshHumansen_GB
dc.titleThe role of ADAMs in disease pathophysiology.en_GB
dc.contributor.departmentDepartment of Pathology and Laboratory Medicine, St. Vincent's University, Hospital, Dublin 4, Ireland. Michael.J.Duffy@ucd.ieen_GB
dc.identifier.journalClinica chimica acta; international journal of clinical chemistryen_GB
dc.description.provinceLeinster-

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