Are natural killer cells protecting the metabolically healthy obese patient?

Hdl Handle:
http://hdl.handle.net/10147/207581
Title:
Are natural killer cells protecting the metabolically healthy obese patient?
Authors:
Lynch, Lydia A; O'Connell, Jean M; Kwasnik, Anna K; Cawood, Thomas J; O'Farrelly, Cliona; O'Shea, Donal B
Affiliation:
Department of Obesity and Immunology, St. Vincent's University Hospital, Dublin, , Ireland. Lydia.lynch@ucd.ie
Citation:
Obesity (Silver Spring). 2009 Mar;17(3):601-5. Epub 2008 Dec 18.
Journal:
Obesity (Silver Spring, Md.)
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207581
DOI:
10.1038/oby.2008.565
PubMed ID:
19238145
Abstract:
With the emerging obesity pandemic, identifying those who appear to be protected from adverse consequences such as type 2 diabetes and certain malignancies will become important. We propose that the circulating immune system plays a role in the development of these comorbidities. Clinical data and blood samples were collected from 52 patients with severe obesity attending a hospital weight-management clinic and 11 lean healthy controls. Patients were classified into metabolically "healthy obese" (n = 26; mean age 42.6 years, mean BMI 46.8 kg/m(2)) or "unhealthy obese" (n = 26; mean age 45 years, mean BMI 47.5 kg/m(2)) groups, based upon standard cutoff points for blood pressure, lipid profile, and fasting glucose. Circulating lymphoid populations and phenotypes were assessed by flow cytometry. Obese patients had significantly less circulating natural killer (NK) and cytotoxic T lymphocytes (CTL) compared to lean controls. There were significantly higher levels of NK cells and CTLs in the healthy obese group compared to the unhealthy obese group (NK: 11.7% vs. 6.5%, P < 0.0001, CD8 13.4% vs. 9.3%, P = 0.04), independent of age and BMI and these NK cells were also less activated in the healthy compared to the unhealthy group (CD69, 4.1% vs. 11.8%, P = 0.03). This is the first time that quantitative differences in the circulating immune system of obese patients with similar BMI but different metabolic profiles have been described. The significantly higher levels of CTLs and NK cells, which express fewer inhibitory molecules, could protect against malignancy, infection, and metabolic disease seen in obesity.
Language:
eng
MeSH:
Adolescent; Adult; Aged; Case-Control Studies; Cell Survival; Diabetes Mellitus, Type 2/epidemiology/metabolism; Female; Humans; Immune System/*physiology; Killer Cells, Natural/*physiology; Male; Middle Aged; Obesity/complications/*metabolism; Risk Factors; T-Lymphocytes, Cytotoxic/physiology; Young Adult
ISSN:
1930-7381 (Print); 1930-7381 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorLynch, Lydia Aen_GB
dc.contributor.authorO'Connell, Jean Men_GB
dc.contributor.authorKwasnik, Anna Ken_GB
dc.contributor.authorCawood, Thomas Jen_GB
dc.contributor.authorO'Farrelly, Clionaen_GB
dc.contributor.authorO'Shea, Donal Ben_GB
dc.date.accessioned2012-02-01T10:31:59Z-
dc.date.available2012-02-01T10:31:59Z-
dc.date.issued2012-02-01T10:31:59Z-
dc.identifier.citationObesity (Silver Spring). 2009 Mar;17(3):601-5. Epub 2008 Dec 18.en_GB
dc.identifier.issn1930-7381 (Print)en_GB
dc.identifier.issn1930-7381 (Linking)en_GB
dc.identifier.pmid19238145en_GB
dc.identifier.doi10.1038/oby.2008.565en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207581-
dc.description.abstractWith the emerging obesity pandemic, identifying those who appear to be protected from adverse consequences such as type 2 diabetes and certain malignancies will become important. We propose that the circulating immune system plays a role in the development of these comorbidities. Clinical data and blood samples were collected from 52 patients with severe obesity attending a hospital weight-management clinic and 11 lean healthy controls. Patients were classified into metabolically "healthy obese" (n = 26; mean age 42.6 years, mean BMI 46.8 kg/m(2)) or "unhealthy obese" (n = 26; mean age 45 years, mean BMI 47.5 kg/m(2)) groups, based upon standard cutoff points for blood pressure, lipid profile, and fasting glucose. Circulating lymphoid populations and phenotypes were assessed by flow cytometry. Obese patients had significantly less circulating natural killer (NK) and cytotoxic T lymphocytes (CTL) compared to lean controls. There were significantly higher levels of NK cells and CTLs in the healthy obese group compared to the unhealthy obese group (NK: 11.7% vs. 6.5%, P < 0.0001, CD8 13.4% vs. 9.3%, P = 0.04), independent of age and BMI and these NK cells were also less activated in the healthy compared to the unhealthy group (CD69, 4.1% vs. 11.8%, P = 0.03). This is the first time that quantitative differences in the circulating immune system of obese patients with similar BMI but different metabolic profiles have been described. The significantly higher levels of CTLs and NK cells, which express fewer inhibitory molecules, could protect against malignancy, infection, and metabolic disease seen in obesity.en_GB
dc.language.isoengen_GB
dc.subject.meshAdolescenten_GB
dc.subject.meshAdulten_GB
dc.subject.meshAgeden_GB
dc.subject.meshCase-Control Studiesen_GB
dc.subject.meshCell Survivalen_GB
dc.subject.meshDiabetes Mellitus, Type 2/epidemiology/metabolismen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshImmune System/*physiologyen_GB
dc.subject.meshKiller Cells, Natural/*physiologyen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshObesity/complications/*metabolismen_GB
dc.subject.meshRisk Factorsen_GB
dc.subject.meshT-Lymphocytes, Cytotoxic/physiologyen_GB
dc.subject.meshYoung Adulten_GB
dc.titleAre natural killer cells protecting the metabolically healthy obese patient?en_GB
dc.contributor.departmentDepartment of Obesity and Immunology, St. Vincent's University Hospital, Dublin, , Ireland. Lydia.lynch@ucd.ieen_GB
dc.identifier.journalObesity (Silver Spring, Md.)en_GB
dc.description.provinceLeinster-

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