Profiling B-type natriuretic peptide in a stable heart failure population: a valuable adjunct to care.

Hdl Handle:
http://hdl.handle.net/10147/207572
Title:
Profiling B-type natriuretic peptide in a stable heart failure population: a valuable adjunct to care.
Authors:
Jan, A; Murphy, N F; O'Loughlin, C; Ledwidge, M; McDonald, K
Affiliation:
Department of Cardiology, Heart Failure Unit, St. Vincent's University Hospital, and University College Dublin, Elm Park, Dublin 4, Ireland.
Citation:
Ir J Med Sci. 2011 Jun;180(2):355-62. Epub 2011 Mar 3.
Journal:
Irish journal of medical science
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207572
DOI:
10.1007/s11845-011-0689-1
PubMed ID:
21369749
Abstract:
AIM: To examine the prognostic importance of absolute values and change in values of BNP in patients with stable heart failure (HF). METHODS: Five-hundred and fifty-nine patients attending a disease management programme were categorized into tertiles of BNP (group 1; </= 95 pg/ml, group 2; 96-249 pg/ml and group 3; >/= 250 pg/ml). A change in BNP between two stable visits was recorded. Patients were followed up for 1 year for death and a composite morbidity measure of HF hospitalization, all-cause hospitalization, unscheduled visits for clinical deterioration(UC) of HF using survival analysis. RESULTS: The risk of the combined morbidity outcome increased with increasing tertiles of BNP (Log rank = 17.8 (2), p < 0.001). Furthermore, a 50 and 25% increase in BNP predicted morbidity in stable HF patients with an initial BNP > 200 pg/ml (p = 0.02) and > 450 pg/ml (p = 0.03), respectively. CONCLUSION: In a stable community HF population, an elevated BNP or an increase in BNP predicts an adverse prognosis thereby potentially identifying a population in need of closer clinical follow-up.
Language:
eng
MeSH:
Aged; Aged, 80 and over; Female; Heart Failure/*blood/mortality; Hospitalization; Humans; Male; Middle Aged; Natriuretic Peptide, Brain/*blood; Predictive Value of Tests; Prognosis
ISSN:
1863-4362 (Electronic); 0021-1265 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorJan, Aen_GB
dc.contributor.authorMurphy, N Fen_GB
dc.contributor.authorO'Loughlin, Cen_GB
dc.contributor.authorLedwidge, Men_GB
dc.contributor.authorMcDonald, Ken_GB
dc.date.accessioned2012-02-01T10:31:43Z-
dc.date.available2012-02-01T10:31:43Z-
dc.date.issued2012-02-01T10:31:43Z-
dc.identifier.citationIr J Med Sci. 2011 Jun;180(2):355-62. Epub 2011 Mar 3.en_GB
dc.identifier.issn1863-4362 (Electronic)en_GB
dc.identifier.issn0021-1265 (Linking)en_GB
dc.identifier.pmid21369749en_GB
dc.identifier.doi10.1007/s11845-011-0689-1en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207572-
dc.description.abstractAIM: To examine the prognostic importance of absolute values and change in values of BNP in patients with stable heart failure (HF). METHODS: Five-hundred and fifty-nine patients attending a disease management programme were categorized into tertiles of BNP (group 1; </= 95 pg/ml, group 2; 96-249 pg/ml and group 3; >/= 250 pg/ml). A change in BNP between two stable visits was recorded. Patients were followed up for 1 year for death and a composite morbidity measure of HF hospitalization, all-cause hospitalization, unscheduled visits for clinical deterioration(UC) of HF using survival analysis. RESULTS: The risk of the combined morbidity outcome increased with increasing tertiles of BNP (Log rank = 17.8 (2), p < 0.001). Furthermore, a 50 and 25% increase in BNP predicted morbidity in stable HF patients with an initial BNP > 200 pg/ml (p = 0.02) and > 450 pg/ml (p = 0.03), respectively. CONCLUSION: In a stable community HF population, an elevated BNP or an increase in BNP predicts an adverse prognosis thereby potentially identifying a population in need of closer clinical follow-up.en_GB
dc.language.isoengen_GB
dc.subject.meshAgeden_GB
dc.subject.meshAged, 80 and overen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHeart Failure/*blood/mortalityen_GB
dc.subject.meshHospitalizationen_GB
dc.subject.meshHumansen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshNatriuretic Peptide, Brain/*blooden_GB
dc.subject.meshPredictive Value of Testsen_GB
dc.subject.meshPrognosisen_GB
dc.titleProfiling B-type natriuretic peptide in a stable heart failure population: a valuable adjunct to care.en_GB
dc.contributor.departmentDepartment of Cardiology, Heart Failure Unit, St. Vincent's University Hospital, and University College Dublin, Elm Park, Dublin 4, Ireland.en_GB
dc.identifier.journalIrish journal of medical scienceen_GB
dc.description.provinceLeinster-

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