Radical prostatectomy outcome when performed with PSA above 20 ng/ml.

Hdl Handle:
http://hdl.handle.net/10147/207568
Title:
Radical prostatectomy outcome when performed with PSA above 20 ng/ml.
Authors:
Connolly, S S; Oon, S F; Carroll, C; Kinsella, S; O'Brien, M F; Mulvin, D W; Quinlan, D M
Affiliation:
Department of Urology, St Vincent's University Hospital, Elm Park, Dublin 4., stephensconnolly@gmail.com
Citation:
Ir Med J. 2011 Apr;104(4):108-11.
Journal:
Irish medical journal
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207568
PubMed ID:
21675092
Abstract:
Many centres currently do not offer radical prostatectomy (RP) to men with high-risk localised prostate cancer due to concerns regarding poor outcome, despite evidence to the contrary. We identified 18 men undergoing RP with serum PSA >20 ng/ml (high-risk by National Comprehensive Cancer Network definition) and minimum follow-up of 12 years (mean 13.5). Mean preoperative PSA was 37.0 ng/ml (Range 21.1-94.0). Prostatectomy pathology reported extracapsular disease in 16 (88.9%), positive surgical margins in 15 (83%) and positive pelvic lymph nodes in 5 (27.8%). Overall and cancer-specific survival at 5 and 10-years was 83.3%, 88.2%, 72% and 76.5% respectively. With complete follow-up 11 (61.1%) are alive, and 5 (27.8%) avoided any adjuvant therapy. Complete continence (defined as no involuntary urine leakage and no use of pads) was achieved in 60%, with partial continence in the remainder. We conclude that surgery for this aggressive variant of localised prostate cancer can result in satisfactory outcome.
Language:
eng
MeSH:
Aged; Humans; Male; Middle Aged; Prostate-Specific Antigen/*blood; *Prostatectomy; Prostatic Neoplasms/blood/mortality/*surgery; Survival Rate
ISSN:
0332-3102 (Print); 0332-3102 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorConnolly, S Sen_GB
dc.contributor.authorOon, S Fen_GB
dc.contributor.authorCarroll, Cen_GB
dc.contributor.authorKinsella, Sen_GB
dc.contributor.authorO'Brien, M Fen_GB
dc.contributor.authorMulvin, D Wen_GB
dc.contributor.authorQuinlan, D Men_GB
dc.date.accessioned2012-02-01T10:31:36Z-
dc.date.available2012-02-01T10:31:36Z-
dc.date.issued2012-02-01T10:31:36Z-
dc.identifier.citationIr Med J. 2011 Apr;104(4):108-11.en_GB
dc.identifier.issn0332-3102 (Print)en_GB
dc.identifier.issn0332-3102 (Linking)en_GB
dc.identifier.pmid21675092en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207568-
dc.description.abstractMany centres currently do not offer radical prostatectomy (RP) to men with high-risk localised prostate cancer due to concerns regarding poor outcome, despite evidence to the contrary. We identified 18 men undergoing RP with serum PSA >20 ng/ml (high-risk by National Comprehensive Cancer Network definition) and minimum follow-up of 12 years (mean 13.5). Mean preoperative PSA was 37.0 ng/ml (Range 21.1-94.0). Prostatectomy pathology reported extracapsular disease in 16 (88.9%), positive surgical margins in 15 (83%) and positive pelvic lymph nodes in 5 (27.8%). Overall and cancer-specific survival at 5 and 10-years was 83.3%, 88.2%, 72% and 76.5% respectively. With complete follow-up 11 (61.1%) are alive, and 5 (27.8%) avoided any adjuvant therapy. Complete continence (defined as no involuntary urine leakage and no use of pads) was achieved in 60%, with partial continence in the remainder. We conclude that surgery for this aggressive variant of localised prostate cancer can result in satisfactory outcome.en_GB
dc.language.isoengen_GB
dc.subject.meshAgeden_GB
dc.subject.meshHumansen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshProstate-Specific Antigen/*blooden_GB
dc.subject.mesh*Prostatectomyen_GB
dc.subject.meshProstatic Neoplasms/blood/mortality/*surgeryen_GB
dc.subject.meshSurvival Rateen_GB
dc.titleRadical prostatectomy outcome when performed with PSA above 20 ng/ml.en_GB
dc.contributor.departmentDepartment of Urology, St Vincent's University Hospital, Elm Park, Dublin 4., stephensconnolly@gmail.comen_GB
dc.identifier.journalIrish medical journalen_GB
dc.description.provinceLeinster-
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