Changes in endometrial natural killer cell expression of CD94, CD158a and CD158b are associated with infertility.

Hdl Handle:
http://hdl.handle.net/10147/207564
Title:
Changes in endometrial natural killer cell expression of CD94, CD158a and CD158b are associated with infertility.
Authors:
McGrath, Emma; Ryan, Elizabeth J; Lynch, Lydia; Golden-Mason, Lucy; Mooney, Eoghan; Eogan, Maeve; O'Herlihy, Colm; O'Farrelly, Cliona
Affiliation:
Education & Research Centre, St. Vincent's University Hospital Dublin, Dublin,, Ireland.
Citation:
Am J Reprod Immunol. 2009 Apr;61(4):265-76.
Journal:
American journal of reproductive immunology (New York, N.Y. : 1989)
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207564
DOI:
10.1111/j.1600-0897.2009.00688.x
PubMed ID:
19260857
Abstract:
PROBLEM: Cycle-dependent fluctuations in natural killer (NK) cell populations in endometrium and circulation may differ, contributing to unexplained infertility. METHOD OF STUDY: NK cell phenotypes were determined by flow cytometry in endometrial biopsies and matched blood samples. RESULTS: While circulating and endometrial T cell populations remained constant throughout the menstrual cycle in fertile and infertile women, circulating NK cells in infertile women increased during the secretory phase. However, increased expression of CD94, CD158b (secretory phase), and CD158a (proliferative phase) by endometrial NK cells from infertile women was observed. These changes were not reflected in the circulation. CONCLUSION: In infertile women, changes in circulating NK cell percentages are found exclusively during the secretory phase and not in endometrium; cycle-related changes in NK receptor expression are observed only in infertile endometrium. While having exciting implications for understanding NK cell function in fertility, our data emphasize the difficulty in attaching diagnostic or prognostic significance to NK cell analyses in individual patients.
Language:
eng
MeSH:
Adult; Antigens, CD3; Antigens, CD56; Cell Count; Cell Separation; Chronobiology Phenomena/immunology; Endometrium/immunology/pathology; Female; Flow Cytometry; Follicular Phase/blood/immunology; Humans; Infertility, Female/blood/*immunology; Killer Cells, Natural/immunology/*metabolism/pathology; Luteal Phase/blood/immunology; NK Cell Lectin-Like Receptor Subfamily D/genetics/immunology/*metabolism; Receptors, KIR2DL1/genetics/immunology/*metabolism; Receptors, KIR2DL3/genetics/immunology/*metabolism; T-Lymphocytes/immunology/metabolism/pathology
ISSN:
1600-0897 (Electronic); 1046-7408 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorMcGrath, Emmaen_GB
dc.contributor.authorRyan, Elizabeth Jen_GB
dc.contributor.authorLynch, Lydiaen_GB
dc.contributor.authorGolden-Mason, Lucyen_GB
dc.contributor.authorMooney, Eoghanen_GB
dc.contributor.authorEogan, Maeveen_GB
dc.contributor.authorO'Herlihy, Colmen_GB
dc.contributor.authorO'Farrelly, Clionaen_GB
dc.date.accessioned2012-02-01T10:31:29Z-
dc.date.available2012-02-01T10:31:29Z-
dc.date.issued2012-02-01T10:31:29Z-
dc.identifier.citationAm J Reprod Immunol. 2009 Apr;61(4):265-76.en_GB
dc.identifier.issn1600-0897 (Electronic)en_GB
dc.identifier.issn1046-7408 (Linking)en_GB
dc.identifier.pmid19260857en_GB
dc.identifier.doi10.1111/j.1600-0897.2009.00688.xen_GB
dc.identifier.urihttp://hdl.handle.net/10147/207564-
dc.description.abstractPROBLEM: Cycle-dependent fluctuations in natural killer (NK) cell populations in endometrium and circulation may differ, contributing to unexplained infertility. METHOD OF STUDY: NK cell phenotypes were determined by flow cytometry in endometrial biopsies and matched blood samples. RESULTS: While circulating and endometrial T cell populations remained constant throughout the menstrual cycle in fertile and infertile women, circulating NK cells in infertile women increased during the secretory phase. However, increased expression of CD94, CD158b (secretory phase), and CD158a (proliferative phase) by endometrial NK cells from infertile women was observed. These changes were not reflected in the circulation. CONCLUSION: In infertile women, changes in circulating NK cell percentages are found exclusively during the secretory phase and not in endometrium; cycle-related changes in NK receptor expression are observed only in infertile endometrium. While having exciting implications for understanding NK cell function in fertility, our data emphasize the difficulty in attaching diagnostic or prognostic significance to NK cell analyses in individual patients.en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAntigens, CD3en_GB
dc.subject.meshAntigens, CD56en_GB
dc.subject.meshCell Counten_GB
dc.subject.meshCell Separationen_GB
dc.subject.meshChronobiology Phenomena/immunologyen_GB
dc.subject.meshEndometrium/immunology/pathologyen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshFlow Cytometryen_GB
dc.subject.meshFollicular Phase/blood/immunologyen_GB
dc.subject.meshHumansen_GB
dc.subject.meshInfertility, Female/blood/*immunologyen_GB
dc.subject.meshKiller Cells, Natural/immunology/*metabolism/pathologyen_GB
dc.subject.meshLuteal Phase/blood/immunologyen_GB
dc.subject.meshNK Cell Lectin-Like Receptor Subfamily D/genetics/immunology/*metabolismen_GB
dc.subject.meshReceptors, KIR2DL1/genetics/immunology/*metabolismen_GB
dc.subject.meshReceptors, KIR2DL3/genetics/immunology/*metabolismen_GB
dc.subject.meshT-Lymphocytes/immunology/metabolism/pathologyen_GB
dc.titleChanges in endometrial natural killer cell expression of CD94, CD158a and CD158b are associated with infertility.en_GB
dc.contributor.departmentEducation & Research Centre, St. Vincent's University Hospital Dublin, Dublin,, Ireland.en_GB
dc.identifier.journalAmerican journal of reproductive immunology (New York, N.Y. : 1989)en_GB
dc.description.provinceLeinster-
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