Late-onset progressive visual loss in a man with unusual MRI findings: MS, Harding's, Leber's or Leber's Plus?

Hdl Handle:
http://hdl.handle.net/10147/207560
Title:
Late-onset progressive visual loss in a man with unusual MRI findings: MS, Harding's, Leber's or Leber's Plus?
Authors:
Cawley, N; Molloy, A; Cassidy, L; Tubridy, N
Affiliation:
Department of Neurology, St. Vincent's University Hospital, Elm Park, Dublin 4,, Ireland.
Citation:
Ir J Med Sci. 2010 Dec;179(4):599-601. Epub 2010 Oct 1.
Journal:
Irish journal of medical science
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207560
DOI:
10.1007/s11845-010-0586-z
PubMed ID:
20882363
Abstract:
Leber's hereditary optic neuropathy (LHON) is a maternally inherited disorder, typically presenting in the second and third decade. We report the case of an elderly gentleman with significant vascular risk factors, presenting with slowly progressive, bilateral, visual loss with high signal lesions in the pericallosal and periventricular deep white matter on MRI brain studies. Possible diagnoses included late-onset MS, ischaemic optic neuropathies, a mitochondrial disorder or an overlap syndrome such as Harding's disease.
Language:
eng
MeSH:
Aged; Disease Progression; Humans; *Magnetic Resonance Imaging; Male; Multiple Sclerosis/diagnosis; Mutation; Optic Atrophy, Hereditary, Leber/*diagnosis/genetics; Vision Disorders/etiology/genetics
ISSN:
1863-4362 (Electronic); 0021-1265 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorCawley, Nen_GB
dc.contributor.authorMolloy, Aen_GB
dc.contributor.authorCassidy, Len_GB
dc.contributor.authorTubridy, Nen_GB
dc.date.accessioned2012-02-01T10:31:21Z-
dc.date.available2012-02-01T10:31:21Z-
dc.date.issued2012-02-01T10:31:21Z-
dc.identifier.citationIr J Med Sci. 2010 Dec;179(4):599-601. Epub 2010 Oct 1.en_GB
dc.identifier.issn1863-4362 (Electronic)en_GB
dc.identifier.issn0021-1265 (Linking)en_GB
dc.identifier.pmid20882363en_GB
dc.identifier.doi10.1007/s11845-010-0586-zen_GB
dc.identifier.urihttp://hdl.handle.net/10147/207560-
dc.description.abstractLeber's hereditary optic neuropathy (LHON) is a maternally inherited disorder, typically presenting in the second and third decade. We report the case of an elderly gentleman with significant vascular risk factors, presenting with slowly progressive, bilateral, visual loss with high signal lesions in the pericallosal and periventricular deep white matter on MRI brain studies. Possible diagnoses included late-onset MS, ischaemic optic neuropathies, a mitochondrial disorder or an overlap syndrome such as Harding's disease.en_GB
dc.language.isoengen_GB
dc.subject.meshAgeden_GB
dc.subject.meshDisease Progressionen_GB
dc.subject.meshHumansen_GB
dc.subject.mesh*Magnetic Resonance Imagingen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMultiple Sclerosis/diagnosisen_GB
dc.subject.meshMutationen_GB
dc.subject.meshOptic Atrophy, Hereditary, Leber/*diagnosis/geneticsen_GB
dc.subject.meshVision Disorders/etiology/geneticsen_GB
dc.titleLate-onset progressive visual loss in a man with unusual MRI findings: MS, Harding's, Leber's or Leber's Plus?en_GB
dc.contributor.departmentDepartment of Neurology, St. Vincent's University Hospital, Elm Park, Dublin 4,, Ireland.en_GB
dc.identifier.journalIrish journal of medical scienceen_GB
dc.description.provinceLeinster-

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