Significant influence of the primary liver disease on the outcomes of hepatic retransplantation.

Hdl Handle:
http://hdl.handle.net/10147/207557
Title:
Significant influence of the primary liver disease on the outcomes of hepatic retransplantation.
Authors:
Qasim, A; Zaman, B M; Geoghegan, J; Maguire, D; Traynor, O; Hegarty, J; McCormick, P A
Affiliation:
Liver Transplant Unit, St Vincent's University Hospital, Dublin, Ireland., asgharqasim@yahoo.co.uk
Citation:
Ir J Med Sci. 2009 Mar;178(1):47-51. Epub 2008 Nov 4.
Journal:
Irish journal of medical science
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207557
DOI:
10.1007/s11845-008-0234-z
PubMed ID:
18982406
Abstract:
BACKGROUND: There are many indications for hepatic retransplantation. AIM: To identify factors influencing retransplantation needs and outcomes. PATIENTS AND METHODS: Retransplantation records from January 1993 to March 2005 were analysed. Patient and disease characteristics and survival outcomes for retransplantation were compared between various groups. RESULTS: Totally, 286 primary and 42 hepatic retransplantations were performed. Retransplantation indications included primary sclerosing cholangitis (PSC), primary biliary cirrhosis, chronic hepatitis C (HCV), chronic active hepatitis (CAH), and alcohol-related disease. Mean follow-up post-retransplantation was 31 +/- 9 months. Actuarial patient survival at 3 months, 1 year, 3 years, 5 years, and at the end of study was 71.4, 69, 59.5, 54.7, and 50%, respectively. Early and late retransplantation had 1-year survival of 73 and 68.5%, respectively. Retransplantation need was significantly higher for PSC, HCV, and CAH. CONCLUSIONS: Hepatic retransplantation remains a successful salvage option for transplant complications; however, its need is significantly influenced by the primary liver disease.
Language:
eng
MeSH:
Adult; Aged; Female; Humans; Ireland/epidemiology; Liver Diseases/epidemiology/mortality/*surgery; Liver Transplantation/*mortality; Male; Middle Aged; Regression Analysis; Retrospective Studies; Risk Factors; Survival Analysis; Treatment Outcome
ISSN:
1863-4362 (Electronic); 0021-1265 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorQasim, Aen_GB
dc.contributor.authorZaman, B Men_GB
dc.contributor.authorGeoghegan, Jen_GB
dc.contributor.authorMaguire, Den_GB
dc.contributor.authorTraynor, Oen_GB
dc.contributor.authorHegarty, Jen_GB
dc.contributor.authorMcCormick, P Aen_GB
dc.date.accessioned2012-02-01T10:31:16Z-
dc.date.available2012-02-01T10:31:16Z-
dc.date.issued2012-02-01T10:31:16Z-
dc.identifier.citationIr J Med Sci. 2009 Mar;178(1):47-51. Epub 2008 Nov 4.en_GB
dc.identifier.issn1863-4362 (Electronic)en_GB
dc.identifier.issn0021-1265 (Linking)en_GB
dc.identifier.pmid18982406en_GB
dc.identifier.doi10.1007/s11845-008-0234-zen_GB
dc.identifier.urihttp://hdl.handle.net/10147/207557-
dc.description.abstractBACKGROUND: There are many indications for hepatic retransplantation. AIM: To identify factors influencing retransplantation needs and outcomes. PATIENTS AND METHODS: Retransplantation records from January 1993 to March 2005 were analysed. Patient and disease characteristics and survival outcomes for retransplantation were compared between various groups. RESULTS: Totally, 286 primary and 42 hepatic retransplantations were performed. Retransplantation indications included primary sclerosing cholangitis (PSC), primary biliary cirrhosis, chronic hepatitis C (HCV), chronic active hepatitis (CAH), and alcohol-related disease. Mean follow-up post-retransplantation was 31 +/- 9 months. Actuarial patient survival at 3 months, 1 year, 3 years, 5 years, and at the end of study was 71.4, 69, 59.5, 54.7, and 50%, respectively. Early and late retransplantation had 1-year survival of 73 and 68.5%, respectively. Retransplantation need was significantly higher for PSC, HCV, and CAH. CONCLUSIONS: Hepatic retransplantation remains a successful salvage option for transplant complications; however, its need is significantly influenced by the primary liver disease.en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAgeden_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshIreland/epidemiologyen_GB
dc.subject.meshLiver Diseases/epidemiology/mortality/*surgeryen_GB
dc.subject.meshLiver Transplantation/*mortalityen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshRegression Analysisen_GB
dc.subject.meshRetrospective Studiesen_GB
dc.subject.meshRisk Factorsen_GB
dc.subject.meshSurvival Analysisen_GB
dc.subject.meshTreatment Outcomeen_GB
dc.titleSignificant influence of the primary liver disease on the outcomes of hepatic retransplantation.en_GB
dc.contributor.departmentLiver Transplant Unit, St Vincent's University Hospital, Dublin, Ireland., asgharqasim@yahoo.co.uken_GB
dc.identifier.journalIrish journal of medical scienceen_GB
dc.description.provinceLeinster-

Related articles on PubMed

All Items in Lenus, The Irish Health Repository are protected by copyright, with all rights reserved, unless otherwise indicated.