Clinicopathologic features of sentinel node metastases predictive of positive axillary clearance in grade 1 invasive breast carcinoma.

Hdl Handle:
http://hdl.handle.net/10147/207534
Title:
Clinicopathologic features of sentinel node metastases predictive of positive axillary clearance in grade 1 invasive breast carcinoma.
Authors:
Hayes, B; McCormack, O; Quinn, C M; McDermott, E W; Evoy, D
Affiliation:
Department of Histopathology, St Vincent's University Hospital, Elm Park, Dublin,, Ireland. brian_hayes@ireland.com
Citation:
Ir J Med Sci. 2009 Dec;178(4):447-51.
Journal:
Irish journal of medical science
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207534
DOI:
10.1007/s11845-009-0350-4
PubMed ID:
19430865
Abstract:
BACKGROUND: Sentinel node (SN) biopsy is widely used to stage breast carcinoma and, when positive, typically leads to axillary clearance (AC). AIMS: This study assesses clinicopathologic features of grade 1 breast carcinoma SNs with the aim of identifying a group of patients, who are likely to have a negative AC and can, therefore, safely be spared further surgery. RESULTS: Two hundred and forty-seven patients with grade 1 invasive carcinoma were identified, of whom 29 had a positive SN. Four patients (13.8%) had a positive AC. Positive AC occurred in 3 of 6 (50%) patients whose SN showed extranodal extension (EE), but in only 1 of 23 (4.3%) patients without EE. All patients were staged as pN1(sn) following SN biopsy: only one, who had a 5.27 mm metastasis with EE, was pN2 following AC. CONCLUSIONS: Extranodal extension is a significant predictor of a positive AC in this group. In its absence, AC did not alter the post-SN biopsy pN stage.
Language:
eng
MeSH:
Adult; Aged; Axilla; Breast Neoplasms/*pathology; Carcinoma/*pathology/secondary; Female; Humans; Lymph Nodes/*pathology; Lymphatic Metastasis; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Predictive Value of Tests; *Sentinel Lymph Node Biopsy
ISSN:
1863-4362 (Electronic); 0021-1265 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorHayes, Ben_GB
dc.contributor.authorMcCormack, Oen_GB
dc.contributor.authorQuinn, C Men_GB
dc.contributor.authorMcDermott, E Wen_GB
dc.contributor.authorEvoy, Den_GB
dc.date.accessioned2012-02-01T10:30:34Z-
dc.date.available2012-02-01T10:30:34Z-
dc.date.issued2012-02-01T10:30:34Z-
dc.identifier.citationIr J Med Sci. 2009 Dec;178(4):447-51.en_GB
dc.identifier.issn1863-4362 (Electronic)en_GB
dc.identifier.issn0021-1265 (Linking)en_GB
dc.identifier.pmid19430865en_GB
dc.identifier.doi10.1007/s11845-009-0350-4en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207534-
dc.description.abstractBACKGROUND: Sentinel node (SN) biopsy is widely used to stage breast carcinoma and, when positive, typically leads to axillary clearance (AC). AIMS: This study assesses clinicopathologic features of grade 1 breast carcinoma SNs with the aim of identifying a group of patients, who are likely to have a negative AC and can, therefore, safely be spared further surgery. RESULTS: Two hundred and forty-seven patients with grade 1 invasive carcinoma were identified, of whom 29 had a positive SN. Four patients (13.8%) had a positive AC. Positive AC occurred in 3 of 6 (50%) patients whose SN showed extranodal extension (EE), but in only 1 of 23 (4.3%) patients without EE. All patients were staged as pN1(sn) following SN biopsy: only one, who had a 5.27 mm metastasis with EE, was pN2 following AC. CONCLUSIONS: Extranodal extension is a significant predictor of a positive AC in this group. In its absence, AC did not alter the post-SN biopsy pN stage.en_GB
dc.language.isoengen_GB
dc.subject.meshAdulten_GB
dc.subject.meshAgeden_GB
dc.subject.meshAxillaen_GB
dc.subject.meshBreast Neoplasms/*pathologyen_GB
dc.subject.meshCarcinoma/*pathology/secondaryen_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshLymph Nodes/*pathologyen_GB
dc.subject.meshLymphatic Metastasisen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshNeoplasm Invasivenessen_GB
dc.subject.meshNeoplasm Stagingen_GB
dc.subject.meshPredictive Value of Testsen_GB
dc.subject.mesh*Sentinel Lymph Node Biopsyen_GB
dc.titleClinicopathologic features of sentinel node metastases predictive of positive axillary clearance in grade 1 invasive breast carcinoma.en_GB
dc.contributor.departmentDepartment of Histopathology, St Vincent's University Hospital, Elm Park, Dublin,, Ireland. brian_hayes@ireland.comen_GB
dc.identifier.journalIrish journal of medical scienceen_GB
dc.description.provinceLeinster-

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