The relationship of omental and subcutaneous adipocyte size to metabolic disease in severe obesity.

Hdl Handle:
http://hdl.handle.net/10147/207495
Title:
The relationship of omental and subcutaneous adipocyte size to metabolic disease in severe obesity.
Authors:
O'Connell, Jean; Lynch, Lydia; Cawood, Tom J; Kwasnik, Anna; Nolan, Niamh; Geoghegan, Justin; McCormick, Aiden; O'Farrelly, Cliona; O'Shea, Donal
Affiliation:
Obesity Research Group, Education and Research Centre, St Vincent's University, Hospital, Dublin, Ireland. jeanoco@gmail.com
Citation:
PLoS One. 2010 Apr 1;5(4):e9997.
Journal:
PloS one
Issue Date:
1-Feb-2012
URI:
http://hdl.handle.net/10147/207495
DOI:
10.1371/journal.pone.0009997
PubMed ID:
20376319
Abstract:
OBJECTIVE: Several studies have reported the existence of a subgroup of obese individuals with normal metabolic profiles. It remains unclear what factors are responsible for this phenomenon. We proposed that adipocyte size might be a key factor in the protection of metabolically healthy obese (MHO) individuals from the adverse effects of obesity. SUBJECTS: Thirty-five patients undergoing bariatric surgery were classified as MHO (n = 15) or metabolically unhealthy obese (MUO, n = 20) according to cut-off points adapted from the International Diabetes Federation definition of the metabolic syndrome. Median body mass index (BMI) was 48 (range 40-71). RESULTS: There was a moderate correlation between omental adipocyte size and subcutaneous adipocyte size (r = 0.59, p<0.05). The MHO group had significantly lower mean omental adipocyte size (80.9+/-10.9 microm) when compared with metabolically unhealthy patients (100.0+/-7.6 microm, p<0.0001). Mean subcutaneous adipocyte size was similar between the two groups (104.1+/-8.5 microm versus 107.9+/-7.1 microm). Omental, but not subcutaneous adipocyte size, correlated with the degree of insulin resistance as measured by HOMA-IR (r = 0.73, p<0.0005), as well as other metabolic parameters including triglyceride/HDL-cholesterol ratio and HbA1c. Twenty-eight patients consented to liver biopsy. Of these, 46% had steatohepatitis and fibrosis. Fifty percent (including all the MHO patients) had steatosis only. Both omental and subcutaneous adipocyte size were significantly associated with the degree of steatosis (r = 0.66, p<0.0001 and r = 0.63, p<0.005 respectively). However, only omental adipocyte size was an independent predictor of the presence or absence of fibrosis. CONCLUSION: Metabolically healthy individuals are a distinct subgroup of the severely obese. Both subcutaneous and omental adipocyte size correlated positively with the degree of fatty liver, but only omental adipocyte size was related to metabolic health, and possibly progression from hepatic steatosis to fibrosis.
Language:
eng
MeSH:
Adipocytes/*pathology; Adult; Body Mass Index; Cell Size; Fatty Liver; Female; Humans; Insulin Resistance; Male; Metabolic Diseases/*diagnosis/pathology; Metabolic Syndrome X/diagnosis/pathology; Middle Aged; Omentum/*pathology; Subcutaneous Fat/*pathology
ISSN:
1932-6203 (Electronic); 1932-6203 (Linking)

Full metadata record

DC FieldValue Language
dc.contributor.authorO'Connell, Jeanen_GB
dc.contributor.authorLynch, Lydiaen_GB
dc.contributor.authorCawood, Tom Jen_GB
dc.contributor.authorKwasnik, Annaen_GB
dc.contributor.authorNolan, Niamhen_GB
dc.contributor.authorGeoghegan, Justinen_GB
dc.contributor.authorMcCormick, Aidenen_GB
dc.contributor.authorO'Farrelly, Clionaen_GB
dc.contributor.authorO'Shea, Donalen_GB
dc.date.accessioned2012-02-01T10:29:27Z-
dc.date.available2012-02-01T10:29:27Z-
dc.date.issued2012-02-01T10:29:27Z-
dc.identifier.citationPLoS One. 2010 Apr 1;5(4):e9997.en_GB
dc.identifier.issn1932-6203 (Electronic)en_GB
dc.identifier.issn1932-6203 (Linking)en_GB
dc.identifier.pmid20376319en_GB
dc.identifier.doi10.1371/journal.pone.0009997en_GB
dc.identifier.urihttp://hdl.handle.net/10147/207495-
dc.description.abstractOBJECTIVE: Several studies have reported the existence of a subgroup of obese individuals with normal metabolic profiles. It remains unclear what factors are responsible for this phenomenon. We proposed that adipocyte size might be a key factor in the protection of metabolically healthy obese (MHO) individuals from the adverse effects of obesity. SUBJECTS: Thirty-five patients undergoing bariatric surgery were classified as MHO (n = 15) or metabolically unhealthy obese (MUO, n = 20) according to cut-off points adapted from the International Diabetes Federation definition of the metabolic syndrome. Median body mass index (BMI) was 48 (range 40-71). RESULTS: There was a moderate correlation between omental adipocyte size and subcutaneous adipocyte size (r = 0.59, p<0.05). The MHO group had significantly lower mean omental adipocyte size (80.9+/-10.9 microm) when compared with metabolically unhealthy patients (100.0+/-7.6 microm, p<0.0001). Mean subcutaneous adipocyte size was similar between the two groups (104.1+/-8.5 microm versus 107.9+/-7.1 microm). Omental, but not subcutaneous adipocyte size, correlated with the degree of insulin resistance as measured by HOMA-IR (r = 0.73, p<0.0005), as well as other metabolic parameters including triglyceride/HDL-cholesterol ratio and HbA1c. Twenty-eight patients consented to liver biopsy. Of these, 46% had steatohepatitis and fibrosis. Fifty percent (including all the MHO patients) had steatosis only. Both omental and subcutaneous adipocyte size were significantly associated with the degree of steatosis (r = 0.66, p<0.0001 and r = 0.63, p<0.005 respectively). However, only omental adipocyte size was an independent predictor of the presence or absence of fibrosis. CONCLUSION: Metabolically healthy individuals are a distinct subgroup of the severely obese. Both subcutaneous and omental adipocyte size correlated positively with the degree of fatty liver, but only omental adipocyte size was related to metabolic health, and possibly progression from hepatic steatosis to fibrosis.en_GB
dc.language.isoengen_GB
dc.subject.meshAdipocytes/*pathologyen_GB
dc.subject.meshAdulten_GB
dc.subject.meshBody Mass Indexen_GB
dc.subject.meshCell Sizeen_GB
dc.subject.meshFatty Liveren_GB
dc.subject.meshFemaleen_GB
dc.subject.meshHumansen_GB
dc.subject.meshInsulin Resistanceen_GB
dc.subject.meshMaleen_GB
dc.subject.meshMetabolic Diseases/*diagnosis/pathologyen_GB
dc.subject.meshMetabolic Syndrome X/diagnosis/pathologyen_GB
dc.subject.meshMiddle Ageden_GB
dc.subject.meshOmentum/*pathologyen_GB
dc.subject.meshSubcutaneous Fat/*pathologyen_GB
dc.titleThe relationship of omental and subcutaneous adipocyte size to metabolic disease in severe obesity.en_GB
dc.contributor.departmentObesity Research Group, Education and Research Centre, St Vincent's University, Hospital, Dublin, Ireland. jeanoco@gmail.comen_GB
dc.identifier.journalPloS oneen_GB
dc.description.provinceLeinster-

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